Results 51 to 60 of about 3,675 (177)

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal

The Journal of Clinical Investigation, 2023
Herpes simplex virus type 2 (HSV-2) coinfection is associated with increased HIV-1 viral loads and expanded tissue reservoirs, but the mechanisms are not well defined.
Carl A. Pierce, Lip Nam Loh, Holly R. Steach, Natalia Cheshenko, Paula Preston-Hurlburt, Fengrui Zhang, Stephanie Stransky, Leah Kravets, Simone Sidoli, William Philbrick, Michel Nassar, Smita Krishnaswamy, Kevan C. Herold, Betsy C. Herold   +13 more
doaj   +1 more source

Delineating gender/sex‐related studies through bibliometric analysis

Journal of the Association for Information Science and Technology, EarlyView.
Abstract The multidisciplinary and socially grounded nature of Women's/Gender/Feminist Studies poses unique challenges for bibliometric analysis, as it extends beyond conventional disciplinary boundaries. This paper makes three key contributions: (1) We propose a novel retrieval method for constructing a corpus of scholarly documents in research areas ...
Natsumi S. Shokida, Diego Kozlowski, Vincent Larivière   +2 more
wiley   +1 more source

Multi‐Scale Hybrid Modeling to Predict Cell Culture Process With Metabolic Phase Transitions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT To advance understanding of cellular metabolism and reduce batch‐to‐batch variability in cell culture processes, this study introduces a multi‐scale hybrid modeling framework designed to simulate and predict the dynamic behavior of CHO cell cultures undergoing metabolic phase transitions.
Keqi Wang, Sarah W. Harcum, Wei Xie
wiley   +1 more source

PARP1 Might Substitute HSF1 to Reactivate Latent HIV-1 by Binding to Heat Shock Element

Cells, 2022
At present, the barrier to HIV-1 functional cure is the persistence of HIV-1 reservoirs. The “shock (reversing latency) and kill (antiretroviral therapy)” strategy sheds light on reducing or eliminating the latent reservoir of HIV-1. However, the current
Xinfeng Xu, Yingtong Lin, Xiaoyun Zeng, Chan Yang, Siqin Duan, Liqiong Ding, Wanzhen Lu, Jian Lin, Xiaoyan Pan, Xiancai Ma, Shuwen Liu   +10 more
doaj   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Epitranscriptomic m6A modifications during reactivation of HIV-1 latency in CD4+ T cells

mBio
Despite effective antiretroviral therapy reducing HIV-1 viral loads to undetectable levels, the presence of latently infected CD4+ T cells poses a major barrier to HIV-1 cure.
Tarun Mishra, Stacia Phillips, Yutao Zhao, Bethany Wilms, Chuan He, Li Wu   +5 more
doaj   +1 more source

NF-κB sub-pathways and HIV cure: A revisit

EBioMedicine, 2021
HIV cure is thwarted by the presence of quiescent yet replication competent HIV-1 (HIV). Antiretroviral therapy (ART) is unable to eradicate reservoirs, and upon cessation of ART, HIV will rebound.
Lilly M. Wong, Guochun Jiang
doaj   +1 more source

Nanophotonic Biosensors and the Paradigm of Trans‐Scale Autonomous Bio‐Integrated Diagnostics for Addressing Health Complexities

Electron, EarlyView.
Physics‐driven advances in optical nanobiosensors for rapid, miniaturized, and point‐of‐care diagnostics for next‐generation decentralized and personalized healthcare based on sensor intelligence. ABSTRACT Public health emergencies and the escalating burden of chronic diseases necessitate a paradigm shift from centralized laboratory testing to rapid ...
Vishal Chaudhary, Harsh Sable, Sonu Sonu, Lakshita Phor, Reddicherla Umapathi, Pradeep Bhadola   +5 more
wiley   +1 more source

Mental health measures among adolescents in 12 low‐ and middle‐income countries: Measurement invariance and cross‐sectional analyses of Disrupting Harm survey data

JCPP Advances, EarlyView.
Abstract Background Nationally representative mental health data in adolescents from low‐ and middle‐income countries (LMICs) are scarce. This study aimed to examine mental health and wellbeing indicators amongst adolescents in 12 LMICs across Eastern and Southern Africa and Southeast Asia. Methods We conducted a secondary analysis of data involving 12,
Ariadna Albajara Sáenz, Sebastian Kurten, Jennifer Saxton, Daniel Kardefelt‐Winther, Tamsin Ford, Amy Orben, Simon R. White   +6 more
wiley   +1 more source