Results 51 to 60 of about 4,485 (189)

INVESTIGATING HIV-1 LATENCY REVERSAL UPON COGNATE ANTIGEN RECOGNITION IN CD4+ T CELLS FROM PEOPLE ON ANTIRETROVIRAL THERAPY [PDF]

, 2023
Despite the advancement in antiretroviral therapy (ART) which effectively prevents viral replication and transmission, there is no cure for Human Immunodeficiency Virus type 1 (HIV-1) infection.
Moskovljevic, Milica
core   +3 more sources

Curaxin CBL0137 has the potential to reverse HIV‐1 latency

Journal of Medical Virology, 2019
AbstractA cure for human immunodeficiency virus type‐1 (HIV‐1) has been hampered by the limitation of current combination antiretroviral therapy (cART) to address the latent reservoirs in HIV‐1 patients. One strategy proposed to eradicate these reservoirs is the “shock and kill” approach, where latency‐reversing agents (LRAs) are used to reactivate and
Maxime J. Jean, Dawei Zhou, Guillaume Fiches, Weili Kong, Huachao Huang, Andrei Purmal, Katerina Gurova, Netty G. Santoso, Jian Zhu   +8 more
openaire   +3 more sources

UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat

mBio, 2021
HIV-1 remains incurable due to viral reservoirs, which lead to durably latent HIV infection. Identifying novel host factors and deciphering the molecular mechanisms involved in the establishment and maintenance of latency are critical to discover new ...
Taizhen Liang, Qiao Zhang, Ziyao Wu, Pei Chen, Yifan Huang, Shuwen Liu, Lin Li   +6 more
doaj   +1 more source

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency.

PLoS Pathogens, 2023
Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1.
Emily Hsieh, Derek H Janssens, Patrick J Paddison, Edward P Browne, Steve Henikoff, Molly OhAinle, Michael Emerman   +6 more
doaj   +1 more source

CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells

iScience
Summary: HIV-1 latency is regulated by chromatin modifying enzymes, and histone deacetylase inhibitors (HDACi) cause reactivation of provirus expression.
Riley M. Horvath, Ivan Sadowski
doaj   +1 more source

Polyanionic carbosilane dendrimers as a new adjuvant in combination with latency reversal agents for HIV treatment

Journal of Nanobiotechnology, 2019
Background The major obstacle impeding human immunodeficiency virus-1 (HIV-1) eradication in antiretroviral treatment (ART) treated HIV-1 subjects is the establishment of long-lived latently infected resting CD4+ T cells. Due to the fact that no drug has
Ignacio Relaño-Rodríguez, Raquel Juárez-Sánchez, Carolina Pavicic, Eduardo Muñoz, Maria Ángeles Muñoz-Fernández   +4 more
doaj   +1 more source

Structure-Activity Relationship Analysis of Benzotriazine Analogues as HIV-1 Latency-Reversing Agents [PDF]

Antimicrobial Agents and Chemotherapy, 2020
“Shock and kill” therapeutic strategies toward HIV eradication are based on the transcriptional activation of latent HIV with a latency-reversing agent (LRA) and the consequent killing of the reactivated cell by either the cytopathic effect of HIV or an arm of the immune system.
Eric S. Sorensen, Amanda B. Macedo, Rachel S. Resop, J. Natalie Howard, Racheal Nell, Indra Sarabia, Daniel Newman, Yanqin Ren, R. Brad Jones, Vicente Planelles, Adam M. Spivak, Alberto Bosque   +11 more
openaire   +2 more sources

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals.

PLoS Pathogens, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Elizabeth R Wonderlich, Krupa Subramanian, Bryan Cox, Ann Wiegand, Carol Lackman-Smith, Michael J Bale, Mars Stone, Rebecca Hoh, Mary F Kearney, Frank Maldarelli, Steven G Deeks, Michael P Busch, Roger G Ptak, Deanna A Kulpa   +13 more
doaj   +1 more source

Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1Research in context

EBioMedicine, 2019
Background: Despite the success of antiretroviral therapy (ART), latent HIV-1 continues to persist in a long-lived population of resting memory CD4+ T cells within those who are infected. Finding a safe and effective means to induce latency reversal (LR)
Jan Kristoff, Mariana L. Palma, Tatiana M. Garcia-Bates, Chengli Shen, Nicolas Sluis-Cremer, Phalguni Gupta, Charles R. Rinaldo, Robbie B. Mailliard   +7 more
doaj   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source