Results 101 to 110 of about 54,634 (147)
Some of the next articles are maybe not open access.
Senotherapeutics and HIV-1 Persistence
Current HIV/AIDS Reports, 2020To review the potential use of senotherapeutics, pharmacologic agents that target senescent cells, in addressing HIV-1 persistence.Treated HIV-1 infection results in a state of immune exhaustion, which may involve reprogramming of infected and bystander cells toward a state of cellular senescence.
Matthew A, Szaniawski, Adam M, Spivak
openaire +2 more sources
Current approaches to assess HIV-1 persistence
Current Opinion in HIV and AIDS, 2016The persistence of HIV within long-lived HIV-infected CD4 T cells is the primary obstacle towards HIV eradication and numerous strategies are currently being evaluated to target and kill HIV-infected cells to ultimately find a cure. HIV reservoirs are classically quantified by standard methods such as integrated HIV DNA (Alu PCR) and/or quantitative ...
Riddhima, Banga +2 more
openaire +2 more sources
Extrachromosomal HIV-1 DNA in Persistently Infected U937 Cells
AIDS Research and Human Retroviruses, 1990Persistent human immunodeficiency virus type 1 (HIV-1) infection of U937 monocytic cells resulted in the accumulation of novel forms of extrachromosomal viral DNA. These DNA species are larger than the genome size of HIV-1 and persist indefinitely. The extrachromosomal viral DNA species (E-DNA) were shown to be structurally stable by subcloning of ...
C D, Pauza, M K, Singh
openaire +2 more sources
HIV-1 Reservoir Persistence and Decay: Implications for Cure Strategies
Current HIV/AIDS Reports, 2022Despite suppressive antiretroviral therapy (ART), a viral reservoir persists in individuals living with HIV that can reignite systemic replication should treatment be interrupted. Understanding how HIV-1 persists through effective ART is essential to develop cure strategies to induce ART-free virus remission.The HIV-1 reservoir resides in a pool of CD4-
Edward F. Kreider, Katharine J. Bar
openaire +2 more sources
Follicular T helper cells: hotspots for HIV-1 persistence
Nature Medicine, 2016Reservoirs of virally infected cells that are resistant to standard antiretroviral therapy make HIV-1 infection an incurable disease. A new study shows that follicular T helper cells in lymph node germinal centers are prime niches for HIV-1 persistence during antiviral therapy.
Mirko, Paiardini, Mathias, Lichterfeld
openaire +2 more sources