Results 11 to 20 of about 119,863 (250)

Bringing social context into global biomedical HIV cure-related research: An urgent call to action [PDF]

Journal of Virus Eradication, 2022
Advances in science have ushered in a wave of new potential curative and control strategies for HIV that could eliminate the current requirement for life-long antiretroviral therapy (ART) for people living with HIV (PLWH).
Annie Miall, Rio McLellan, Krista Dong, Thumbi Ndung'u, Parya Saberi, John A. Sauceda, Karine Dubé   +6 more
doaj   +7 more sources

Use of ‘eradication’ in HIV cure-related research: a public health debate [PDF]

BMC Public Health, 2018
Background The landscape of Human Immunodeficiency Virus (HIV) research has changed drastically over the past three decades. With the remarkable success of antiretroviral treatment (ART) in decreasing AIDS-related mortality, some researchers have shifted
Karine Dubé, Stuart Luter, Breanne Lesnar, Luke Newton, Jerome Galea, Brandon Brown, Sara Gianella   +6 more
doaj   +7 more sources

Ethical considerations for HIV cure-related research at the end of life [PDF]

BMC Medical Ethics, 2018
Background The U.S. National Institute of Allergies and Infectious Diseases (NIAID) and the National Institute of Mental Health (NIMH) have a new research priority: inclusion of terminally ill persons living with HIV (PLWHIV) in HIV cure-related research.
Karine Dubé, Sara Gianella, Susan Concha-Garcia, Susan J Little, Andy Kaytes, Jeff Taylor, Kushagra Mathur, Sogol Javadi, Anshula Nathan, Hursch Patel, Stuart Luter, Sean Philpott-Jones, Brandon Brown, Davey Smith   +13 more
doaj   +7 more sources

Resolving Challenges in HIV Cure–Related Research: Protocol for a Modified Delphi Consensus-Building Process [PDF]

JMIR Research Protocols
BackgroundHIV cure–related research is expanding rapidly, bringing both new opportunities and ethical challenges. Historically, clinical trials for novel HIV treatments have underrepresented populations most affected by HIV, such ...
John Sauceda, Anastasia Korolkova, Lidia Rodriguez Garcia, Bridgette Picou, Ali Ahmed, Karine Dubé   +5 more
doaj   +4 more sources

‘It is scary to pause treatment’: perspectives on HIV cure-related research and analytical treatment interruptions from women diagnosed during acute HIV in Durban, South Africa: Socio-Behavioral research [PDF]

HIV Research & Clinical Practice
Background HIV remains a major challenge in KwaZulu-Natal, South Africa, particularly for young women who face disproportionate risks and barriers to prevention and treatment. Most HIV cure trials, however, occur in high-income countries.
Deli Mthimkhulu, Krista L. Dong, Mzwakhe Wiseman Ngcobo, Deborah Mindry, Ayanda Zulu, Ntombifuthi Langa, Luyanda Maphalala, Vanessa Pillay, Maud Mthembu, Annie Miall, Whitney Tran, Ana Dillen, Fang Wan, Ali Ahmed, Jamila K. Stockman, Maryam Hussain, Thumbi Ndung’u, Karine Dubé   +17 more
doaj   +3 more sources

Ethical and practical considerations for interventional HIV cure-related research at the end-of-life: A qualitative study with key stakeholders in the United States. [PDF]

PLoS ONE, 2021
BackgroundA unique window of opportunity currently exists to generate ethical and practical considerations presented by interventional HIV cure-related research at the end-of-life (EOL).
John Kanazawa, Sara Gianella, Susanna Concha-Garcia, Jeff Taylor, Andy Kaytes, Christopher Christensen, Hursch Patel, Samuel Ndukwe, Stephen Rawlings, Steven Hendrickx, Susan Little, Brandon Brown, Davey Smith, Karine Dubé   +13 more
doaj   +7 more sources

Considerations for Increasing Racial, Ethnic, Gender, and Sexual Diversity in HIV Cure-Related Research with Analytical Treatment Interruptions: A Qualitative Inquiry. [PDF]

AIDS Res Hum Retroviruses, 2022
Despite disproportionate incidence and prevalence of HIV among transgender individuals, cisgender women, and racial and ethnic minority groups, all remain underrepresented in HIV cure research. As HIV cure trials are scaled up, there is emerging research on ways to mitigate risks of HIV acquisition for sexual partners of analytical treatment ...
Dubé K, Kanazawa J, Campbell C, Boone CA, Maragh-Bass AC, Campbell DM, Agosto-Rosario M, Stockman JK, Diallo DD, Poteat T, Johnson M, Saberi P, Sauceda JA.   +12 more
europepmc   +6 more sources

"I Would Absolutely Need to Know That My Partner Is Still Going to be Protected": Perceptions of HIV Cure-Related Research Among Diverse HIV Serodifferent Couples in the United States. [PDF]

AIDS Res Hum Retroviruses, 2023
Most HIV cure studies remain in the early stage of investigation and may carry clinical risks to the participants and, in some cases, their partners. Surprisingly little sociobehavioral research has investigated the perceptions of couples-including HIV serodifferent couples-around HIV cure research, including factors that would influence recruitment ...
Dubé K, Agarwal H, Stockman JK, Auerbach JD, Sauceda JA, Conroy AA, Johnson MO.   +6 more
europepmc   +6 more sources

If We Build It, Will They Come? Perceptions of HIV Cure-Related Research by People Living with HIV in Four U.S. Cities: A Qualitative Focus Group Study. [PDF]

AIDS Res Hum Retroviruses, 2018
Global interest and investment in the search for an HIV cure has increased. Research has focused on what experts refer to as a sterilizing or eradicating cure, where HIV is eliminated from the body, and on what is often called a functional cure, where HIV remains, kept durably suppressed in the absence of antiretroviral treatment and therapy (ART ...
Sylla L, Evans D, Taylor J, Gilbertson A, Palm D, Auerbach JD, Dubé K.   +6 more
europepmc   +5 more sources

A landscape analysis of HIV cure-related clinical research in 2019

Journal of Virus Eradication, 2020
Objectives: In 2018, we surveyed investigators conducting HIV cure-related clinical research, drawing on information from the online listing established by Treatment Action Group (TAG).
Liz Barr, Richard Jefferys
doaj   +3 more sources