Results 31 to 40 of about 119,863 (250)

Vulnerability in Biomedical Research: A Historical Reflection and Practical Implications for HIV Cure-Related Research. [PDF]

AIDS Res Hum Retroviruses
The concept of vulnerability in bioethics was first referenced in 1979, when the Belmont Report highlighted the need for special consideration of certain populations in the application of its general principles of respect for persons, beneficence, and justice in research with human participants.
Rao E, Taylor J, Kaytes A, Concha-Garcia S, Riggs PK, Smith DM, Dubé K, Gianella S.   +7 more
europepmc   +3 more sources

An HIV long-term survivor and activist’s perspective on HIV cure-related research – Nelson vergel

HIV Research & Clinical Practice
Nelson Vergel
doaj   +3 more sources

Attitudes and perceptions of next-of-kin/loved ones toward end-of-life HIV cure-related research: A qualitative focus group study in Southern California. [PDF]

PLoS One, 2021
As end-of-life (EOL) HIV cure-related research expands, understanding perspectives of participants’ next-of-kin (NOK) is critical to maintaining ethical study conduct. We conducted two small focus groups and two one-on-one interviews using focus group guides with the NOK of Last Gift study participants at the University of California, San Diego (UCSD).
Javadi SS, Mathur K, Concha-Garcia S, Patel H, Perry KE, Lo M, Taylor J, Kaytes A, Little S, Gianella S, Smith D, Dubé K.   +11 more
europepmc   +7 more sources

"We are looking at the future right now": community acceptability of a home-based viral load test device in the context of HIV cure-related research with analytical treatment interruptions in the United States. [PDF]

HIV Res Clin Pract, 2022
People with HIV (PWH) and community members have advocated for the development of a home-based viral load test device that could make analytical treatment interruptions (ATIs) less burdensome.We assessed community acceptability of a novel home-based viral load test device.In 2021, we conducted 15 interviews and 3 virtual focus groups with PWH involved ...
Dubé K, Kanazawa J, Roebuck C, Johnson S, Carter WB, Dee L, Peterson B, Lynn KM, Lalley-Chareczko L, Hiserodt E, Kim S, Rosenbloom D, Evans BR, Anderson M, Hazuda DJ, Shipley L, Bateman K, Howell BJ, Mounzer K, Tebas P, Montaner LJ.   +20 more
europepmc   +4 more sources

The Use of Ultra-Sensitive Molecular Assays in HIV Cure-Related Research. [PDF]

J AIDS Clin Res, 2013
Ultra-sensitive laboratory assays based on the Polymerase Chain Reaction (PCR) are playing an increasingly important role in HIV cure-related research. This article reviews the different assays available and how they have evolved. There is a great need for their standardization and for the establishment of reference reagents and testing algorithms to ...
Kibirige C.
europepmc   +6 more sources

People with HIV at the end-of-life and their next-of-kin/loved ones are willing to participate in interventional HIV cure-related research. [PDF]

AIDS, 2023
Introduction: The Last Gift study at the University of California San Diego (UCSD), United States enrolls terminally ill people with HIV (PWH) in HIV cure research. Methods: From 2017 to 2022, we conducted surveys with Last Gift participants and their next-of-kin/loved ones to ...
Ndukwe SO, Patel H, Shelton B, Concha-Garcia S, Dullano C, Solso S, Hendrickx S, Riggs PK, Villa TJ, Kaytes A, Taylor J, Little SJ, Lessard D, Arora AK, Costiniuk CT, Eskaf S, Smith DM, Gianella S, Dubé K.   +18 more
europepmc   +5 more sources

Perceptions of HIV cure research among people living with HIV in Australia. [PDF]

PLoS ONE, 2018
Participation in HIV cure-related clinical trials that involve antiretroviral treatment (ART) interruption may pose substantial individual risks for people living with HIV (PLHIV) without any therapeutic benefit.
Jennifer Power, Andrew Westle, Gary W Dowsett, Jayne Lucke, Joseph D Tucker, Jeremy Sugarman, Sharon R Lewin, Sophie Hill, Graham Brown, Jack Wallace, Jacqui Richmond   +10 more
doaj   +1 more source

Exploring Stigma and Self-Image: Mixed-Methods Insights from HIV Cure-Related Research Participants Undergoing Analytical Treatment Interruptions. [PDF]

AIDS Patient Care STDS
This mixed-methods study explored self-image among people with HIV participating in an HIV cure-related study involving analytical treatment interruptions (ATIs). Using both quantitative and qualitative approaches, we described how self-image emerged across study participation, focusing on internalized stigma, emotional strengths, and the psychosocial ...
Meanley S, Rodriguez Garcia L, Lisha NE, Ahmed A, Korolkova A, Figueroa T, Nguyen E, J Peluso M, Cohn LB, Deeks S, Dubé K, Sauceda J.   +11 more
europepmc   +3 more sources

Ethics of HIV cure research: an unfinished agenda

BMC Medical Ethics, 2021
Background The pursuit of a cure for HIV is a high priority for researchers, funding agencies, governments and people living with HIV (PLWH). To date, over 250 biomedical studies worldwide are or have been related to discovering a safe, effective, and ...
Karine Dubé, John Kanazawa, Jeff Taylor, Lynda Dee, Nora Jones, Christopher Roebuck, Laurie Sylla, Michael Louella, Jan Kosmyna, David Kelly, Orbit Clanton, David Palm, Danielle M. Campbell, Morénike Giwa Onaiwu, Hursch Patel, Samuel Ndukwe, Laney Henley, Mallory O. Johnson, Parya Saberi, Brandon Brown, John A. Sauceda, Jeremy Sugarman   +21 more
doaj   +1 more source

Re-examining the HIV ‘functional cure’ oxymoron: Time for precise terminology?

Journal of Virus Eradication, 2020
For over a decade, the binary concepts of ‘sterilizing’ versus ‘functional’ cure have provided an organizing framework for the field of HIV cure-related research.
Karine Dubé, Loreen Willenberg, Lynda Dee, Laurie Sylla, Jeff Taylor, Christopher Roebuck, David Palm, Danielle Campbell, Luke Newton, Hursch Patel, Kelly E. Perry, John Kanazawa, Jo Gerrard, Brandon Brown, Parya Saberi, John A. Sauceda, Michael J. Peluso   +16 more
doaj   +1 more source