Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects
Immunology, Volume 176, Issue 3, Page 277-303, November 2025.The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder +4 more
wiley +1 more source
Mutant CD4 Molecules with Improved Binding to HIV Envelope Protein gp120 Selected by Phage Display
Virology, 1997 Phage-display methodology has been used to select variant CD4 proteins exhibiting increased binding to the surface envelope glycoprotein, gp120, of Human Immunodeficiency Virus Type-1. To facilitate the selection, a library of mutant CD4 proteins was constructed by cloning a PCR-generated error prone population of the first two domains of CD4 into the ...
Krykbaev, Rustem +2 more
openaire +2 more sources
Coupling of HIV-1 gp120-derived Core Protein to Paramagnetic Beads and Adsorption Assays
Bio-Protocol, 2015 Analysis of the functional activity in polyclonal serum following immunization of a complex protein or glycoprotein immunogen is a very important but tedious process.
Jidnyasa Ingale, Richard Wyatt
doaj +1 more source
RNA interference approaches for treatment of HIV-1 infection. [PDF]
, 2015 HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L +2 more
core +1 more source
HIV‐1 viral protein effect on cerebral microvasculature: An in vitro blood–brain barrier model
Physiological Reports, Volume 13, Issue 19, October 2025.Abstract The central nervous system (CNS) serves as a sanctuary for the Human Immunodeficiency Virus (HIV), which is facilitated by HIV's ability to breach the blood–brain barrier (BBB). BBB dysfunction occurs in the earliest stages of an HIV‐1 infection.
Sinelisiwe Matubatuba +5 more
wiley +1 more source
Characterization of Host-Cell Line Specific Glycosylation Profiles of Early Transmitted/Founder HIV-1 gp120 Envelope Proteins [PDF]
Journal of Proteome Research, 2013 Glycosylation plays an essential role in regulating protein function by modulating biological, structural, and therapeutic properties. However, due to its inherent heterogeneity and diversity, the comprehensive analysis of protein glycosylation remains a challenge.
Go, Eden P. +5 more
openaire +3 more sources
HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells.
PLoS Pathogens, 2007 The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 is a vaccine immunogen that can signal via several cell surface receptors.
Meimei Shan +10 more
doaj +1 more source
B cell recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous primate CD4. [PDF]
PLoS Pathogens, 2008 The surface HIV-1 exterior envelope glycoprotein, gp120, binds to CD4 on the target cell surface to induce the co-receptor binding site on gp120 as the initial step in the entry process.
Mattias N E Forsell +11 more
doaj +1 more source
Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance
Advanced Science, Volume 12, Issue 34, September 11, 2025.Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai +5 more
wiley +1 more source
Search for antiviral functions of potentially protective antibodies against V2 region of HIV-1
Human Vaccines & Immunotherapeutics, 2020 In the only successful RV144 vaccine trial to date, high levels of antibodies (Abs) against the V2 region of the virus envelope protein gp120 correlated with reduced HIV-1 infection.
Miroslaw K. Gorny
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