Results 11 to 20 of about 34,307 (290)
Viruses, 2020 Peptides derived from the C-terminal heptad repeat (CHR) region of HIV-1 gp41 is potent viral membrane fusion inhibitors, such as the first clinically approved peptide drug T20 and a group of newly-designed peptides.
Danwei Yu +7 more
doaj +2 more sources
HIV-1 resistance to fusion inhibitors
, 2007 Fusion inhibitors, such as T-20 and T-1249, block HIV-1 entry by preventing 6-helix-bundle formation of gp41 and represent a new class of antiretroviral drugs. The present study analyzed the susceptibility of highly divergent HIV-1 strains to T-20 and T-1249 inhibition and the mechanism(s) mediating resistance to these fusion inhibitors.
Chinnadurai, Raghavan
openaire +3 more sources
Frontiers in Cellular and Infection Microbiology, 2022 Given the high variability and drug-resistance problem by human immunodeficiency virus type 1 (HIV-1), the development of bispecific or multi-specific inhibitors targeting different steps of HIV entry is highly appreciated. We previously generated a very
Hongxia Yan +14 more
doaj +1 more source
Clinical perspective of fusion inhibitors for treatment of HIV [PDF]
Journal of Antimicrobial Chemotherapy, 2004 The number of antiretroviral-experienced HIV patients with multiple resistances against the currently available antiretroviral drug classes is increasing substantially. Therapeutic options for this specific group of patients are limited. The fusion inhibitor enfuvirtide represents the first new therapeutic option from a new drug class for this patient ...
J K, Rockstroh, S, Mauss
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Resistance to enfuvirtide, the first HIV fusion inhibitor [PDF]
Journal of Antimicrobial Chemotherapy, 2004 Fusion inhibitors are a new class of antiretroviral drugs (ARVs) for the treatment of human immunodeficiency virus infection. Enfuvirtide is the first in this class to reach market approval. Fusion inhibitors block the last step in the three-step viral entry process consisting of attachment, co-receptor binding and fusion, thereby preventing viral ...
Michael L, Greenberg, Nick, Cammack
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Approaches for Identification of HIV-1 Entry Inhibitors Targeting gp41 Pocket
Viruses, 2013 The hydrophobic pocket in the HIV-1 gp41 N-terminal heptad repeat (NHR) domain plays an important role in viral fusion and entry into the host cell, and serves as an attractive target for development of HIV-1 fusion/entry inhibitors. The peptide anti-HIV
Asim K. Debnath +5 more
doaj +1 more source
Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]
, 2013 HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
core +1 more source
Emerging Microbes and Infections, 2022 Emerging studies indicate that infusion of HIV-resistant cells could be an effective strategy to achieve a sterilizing or functional cure. We recently reported that glycosylphosphatidylinositol (GPI)-anchored nanobody or a fusion inhibitory peptide can ...
Yue Chen +7 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2019 Cell-to-cell spread of HIV permits ongoing viral replication in the presence of antiretroviral therapy and is suggested to be a major contributor to sexual transmission by mucosal routes.
Mohammad Mamun Alam +10 more
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Targeting the MLL complex in acute leukemia [PDF]
, 2014 Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
core +1 more source