Results 21 to 30 of about 33,240 (248)

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

Evidence Showing that Tetraspanins Inhibit HIV-1-Induced Cell-Cell Fusion at a Post-Hemifusion Stage

Viruses, 2014
Human immunodeficiency virus type 1 (HIV-1) transmission takes place primarily through cell-cell contacts known as virological synapses. Formation of these transient adhesions between infected and uninfected cells can lead to transmission of viral ...
Menelaos Symeonides, Marie Lambelé, Nathan H. Roy, Markus Thali   +3 more
doaj   +1 more source

Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate

eLife, 2020
Fusion of HIV-1 with the membrane of its target cell, an obligate first step in virus infectivity, is mediated by binding of the viral envelope (Env) spike protein to its receptors, CD4 and CCR5/CXCR4, on the cell surface.
Mark S Ladinsky, Priyanthi NP Gnanapragasam, Zhi Yang, Anthony P West, Michael S Kay, Pamela J Bjorkman   +5 more
doaj   +1 more source

HIV-1 inhibitory properties of eCD4-Igmim2 determined using an Env-mediated membrane fusion assay. [PDF]

PLoS ONE, 2018
Human Immunodeficiency Virus-1 (HIV-1) entry is dependent on the envelope glycoprotein (Env) that is present on the virion and facilitates fusion between the envelope and the cellular membrane.
Edward Yang, Matthew R Gardner, Amber S Zhou, Michael Farzan, Ann M Arvin, Stefan L Oliver   +5 more
doaj   +1 more source

Conserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors

Viruses, 2019
Entry of HIV-1 into target cells is mediated by its envelope (Env) glycoprotein composed of the receptor binding subunit gp120 and the fusion protein gp41. Refolding of the gp41 N- and C-terminal heptad repeats (NHR and CHR) into a six-helix bundle (6-HB)
Xiuzhu Geng, Zixuan Liu, Danwei Yu, Bo Qin, Yuanmei Zhu, Sheng Cui, Huihui Chong, Yuxian He   +7 more
doaj   +1 more source

Os receptores das quimiocinas e a sua importância no ciclo replicativo do vírus da imunodeficiência humana: implicações clínicas e terapéuticas.

Acta Médica Portuguesa, 2008
Human immunodeficiency virus (HIV) infection of host cells begins with binding of viral envelope (Env) surface (SU) glycoprotein to specific receptors present at plasma cell membrane.
J M Azevedo-Pereira, Q Santos-Costa
doaj   +1 more source

Intercellular adhesion molecule 1 promotes HIV-1 attachment but not fusion to target cells. [PDF]

PLoS ONE, 2012
Incorporation of intercellular adhesion molecule 1 (ICAM-1) into HIV-1 particles is known to markedly enhance the virus binding and infection of cells expressing lymphocyte function-associated antigen-1 (LFA-1). At the same time, ICAM-1 has been reported
Naoyuki Kondo, Gregory B Melikyan
doaj   +1 more source

HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics

Journal of the Formosan Medical Association, 2010
Human immunodeficiency virus (HIV)-1 infection is initiated by the binding of gp120 envelope glyco-protein to its cell receptor (CD4) and a coreceptor (CXCR4 or CCR5), followed by a series of conformational changes in the gp41 transmembrane subunit ...
Chungen Pan, Shuwen Liu, Shibo Jiang
doaj   +1 more source

The improved efficacy of Sifuvirtide compared with enfuvirtide might be related to its selectivity for the rigid biomembrane, as determined through surface plasmon resonance. [PDF]

PLoS ONE, 2017
Most mechanistic studies on human immunodeficiency virus (HIV) peptide fusion inhibitors have focused on the interactions between fusion inhibitors and viral envelope proteins.
Ping Cao, Guifang Dou, Yuanguo Cheng, Jinjing Che   +3 more
doaj   +1 more source

Identification of minimal sequence for HIV-1 fusion inhibitors [PDF]

Bioorganic & Medicinal Chemistry, 2008
Emergence of multi-drug resistant HIV-1 is a serious problem for AIDS treatment. Recently, the virus-cell membrane fusion process has been identified as a promising target for the development of novel drugs against these resistant variants. In this study, we identified a 29-residue peptide fusion inhibitor, SC29EK, which shows activity comparable to ...
Nishikawa, Hiroki, Oishi, Shinya, Fujita, Mizuno, Watanabe, Kentaro, Tokiwa, Rei, Ohno, Hiroaki, Kodama, Eiichi, Izumi, Kazuki, Kajiwara, Keiko, Naitoh, Takeshi, Matsuoka, Masao, Otaka, Akira, Fujii, Nobutaka   +12 more
openaire   +2 more sources