Results 131 to 140 of about 86,566 (299)

Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives

Molecules, 2010
Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide ...
Li-Ming Hu, Jian-Jun Tan, Cheng-Chu Zeng, Hong-Qiu He, Zi-Guo Jiao, Cun-Xin Wang   +5 more
doaj   +1 more source

Halogen Bonding in Nucleic Acid Complexes

, 2017
Halogen bonding (X-bonding) has attracted notable attention among noncovalent interactions. This highly directional attraction between a halogen atom and an electron donor has been exploited in knowledge-based drug design. A great deal of information has
Kolář, Michal H., Tabarrini, Oriana
core   +1 more source

Identification of drug resistance mutations in HIV from constraints on natural evolution [PDF]

, 2015
Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its evolution is constrained by interactions between mutations in its fitness landscape.
Barton, John P., Butler, Thomas C., Chakraborty, Arup K., Kardar, Mehran   +3 more
core   +2 more sources

Strategies to Manage Dosing Deviations and Interruptions of Cabotegravir Long‐Acting Intramuscular Injections

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Long‐acting cabotegravir is approved for HIV treatment and prevention. To guide management of dosing deviations and interruptions, concentration‐time profiles for monthly and every 2 months regimens were simulated using a population pharmacokinetic (PPK) model.
Kelong Han, Ronald D. D'Amico, William R. Spreen, Susan L. Ford   +3 more
wiley   +1 more source

Functional Relevance of CASP16 Nucleic Acid Predictions as Evaluated by Structure Providers

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 51-78, January 2026.
ABSTRACT Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes, experimental model building, and many other applications.
Rachael C. Kretsch, Reinhard Albrecht, Ebbe S. Andersen, Hsuan‐Ai Chen, Wah Chiu, Rhiju Das, Jeanine G. Gezelle, Marcus D. Hartmann, Claudia Höbartner, Yimin Hu, Shekhar Jadhav, Philip E. Johnson, Christopher P. Jones, Deepak Koirala, Emil L. Kristoffersen, Eric Largy, Anna Lewicka, Cameron D. Mackereth, Marco Marcia, Michela Nigro, Manju Ojha, Joseph A. Piccirilli, Phoebe A. Rice, Heewhan Shin, Anna‐Lena Steckelberg, Zhaoming Su, Yoshita Srivastava, Liu Wang, Yuan Wu, Jiahao Xie, Nikolaj H. Zwergius, John Moult, Andriy Kryshtafovych   +32 more
wiley   +1 more source

Frequency of Major Transmitted Integrase Resistance in Poland Remains Low Despite Change in Subtype Variability

Viruses
With the widespread use of integrase inhibitors and the expanding use of long-acting cabotegravir in both pre-exposure prophylaxis and antiretroviral treatment, molecular surveillance on the transmission of integrase resistance has regained clinical ...
Kaja Mielczak, Karol Serwin, Anna Urbańska, Bogusz Aksak-Wąs, Malwina Karasińska-Cieślak, Elżbieta Mularska, Adam Witor, Paweł Jakubowski, Maria Hlebowicz, Monika Bociąga-Jasik, Elżbieta Jabłonowska, Aleksandra Szymczak, Bartosz Szetela, Władysław Łojewski, Miłosz Parczewski   +14 more
doaj   +1 more source

Microwave Assisted Organic Synthesis (MAOS) of Small Molecules as Potential HIV-1 Integrase Inhibitors

Molecules, 2011
Integrase (IN) represents a clinically validated target for the development of antivirals against human immunodeficiency virus (HIV). In recent years our research group has been engaged in the stucture-function study of this enzyme and in the development
Alba Chimirri, Caterina Elisa Faliti, Zeger Debyzer, Rosaria Gitto, Laura De Luca, Sara De Grazia, Stefania Ferro   +6 more
doaj   +1 more source

HIV-1 Integrase Inhibitors That Are Broadly Effective against Drug-Resistant Mutants

Antimicrobial Agents and Chemotherapy, 2018
Integrase strand transfer inhibitors (INSTIs) have emerged as clinically effective therapeutics that inhibit HIV-1 replication by blocking the strand transfer reaction catalyzed by HIV-1 integrase (IN). Of the three FDA-approved INSTIs, dolutegravir (DTG)
Steven J. Smith, X. Zhao, T. Burke, S. Hughes   +3 more
semanticscholar   +1 more source

Outcomes of real‐world initiation of long‐acting injectable cabotegravir and rilpivirine (LA‐I CAB + RPV) in individuals with viraemia: A systematic review of baseline characteristics, virological failure outcomes and discontinuations

HIV Medicine, Volume 27, Issue 1, Page 42-57, January 2026.
Abstract Background When using long‐acting injectable cabotegravir and rilpivirine (CAB + RPV) in individuals with viraemia, beyond small cohorts, little is known about baseline characteristics, virological failure outcomes, resistance emergence, re‐suppression and discontinuation.
Alexa Elias, Chloé Pasin, Melanie Smuk, Amy Paterson, Chloe M. Orkin   +4 more
wiley   +1 more source

In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors

Advances in Virology, 2012
Most antiretroviral medical treatments were developed and tested principally on HIV-1 B nonrecombinant strain, which represents less than 10% of the worldwide HIV-1-infected population.
Xiaoju Ni, Safwat Abdel-Azeim, Elodie Laine, Rohit Arora, Osamuede Osemwota, Anne-Geneviève Marcelin, Vincent Calvez, Jean-François Mouscadet, Luba Tchertanov   +8 more
doaj   +1 more source