Results 131 to 140 of about 71,892 (273)

Brief Histories of Retroviral Integration Research and Associated International Conferences

Viruses
The field of retroviral integration research has a long history that started with the provirus hypothesis and subsequent discoveries of the retroviral reverse transcriptase and integrase enzymes.
Duane P. Grandgenett, Alan N. Engelman
doaj   +1 more source

Twenty-six years of HIV science: an overview of anti-HIV drugs metabolism

Brazilian Journal of Pharmaceutical Sciences, 2011
From the identification of HIV as the agent causing AIDS, to the development of effective antiretroviral drugs, the scientific achievements in HIV research over the past twenty-six years have been formidable.
Carolina Horta Andrade, Lenis Medeiros de Freitas, Valéria de Oliveira   +2 more
doaj   +1 more source

A New Class of HIV-1 Integrase Inhibitors: The 3,3,3‘,3‘-Tetramethyl-1,1‘-spirobi(indan)-5,5‘,6,6‘-tetrol Family [PDF]

, 2000
Valentina Molteni, Denise Rhodes, Kathleen Rubins, Mark Hansen, Frederic D. Bushman, Jay S. Siegel   +5 more
openalex   +1 more source

Selectivity for strand-transfer over 3′-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme–DNA interactions in the active site

Nucleic Acids Research, 2016
Integrase strand transfer inhibitors (INSTIs) are highly effective against HIV infections. Co-crystal structures of the prototype foamy virus intasome have shown that all three FDA-approved drugs, raltegravir (RAL), elvitegravir and dolutegravir (DTG ...
M. Métifiot, Barry C. Johnson, E. Kiselev, Laura E. Marler, X. Zhao, T. Burke, C. Marchand, S. Hughes, Y. Pommier   +8 more
semanticscholar   +1 more source

HIV resistance to raltegravir

European Journal of Medical Research, 2009
Similar to all antiretroviral drugs, failure of raltegravirbased treatment regimens to fully supress HIV replication almost invariably results in emergence of HIV resistance to this new drug.
Clavel François
doaj   +1 more source

HIV, TB and ART: the CD4 enigma [PDF]

arXiv, 2012
The concentration of CD4 T-lymphocytes (CD4 count), in a person's plasma is widely used to decide when to start HIV-positive people on anti-retroviral therapy (ART) and to predict the impact of ART on the future course of HIV and tuberculosis (TB). However, CD4 cell-counts vary widely within and among populations and depend on many factors besides HIV ...
arxiv  

Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: A single mode of inhibition for the three HIV enzymes? [PDF]

, 2006
María‐José Camarasa, Sonsoles Velázquez, Ana San‐Félix, Marı́a-Jesús Pérez-Pérez, Federico Gago   +4 more
openalex   +1 more source

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site [PDF]

, 2006
Laith Q. Al‐Mawsawi, Valery Fikkert, Raveendra Dayam, Myriam Witvrouw, Terrence R. Burke, Christoph H. Borchers, Nouri Neamati   +6 more
openalex   +1 more source

Novel HIV Integrase Inhibitors with Anti-HIV Activity: Insights into Integrase Inhibition from Docking Studies [PDF]

, 2006
Arthur G. Cox, Vasu Nair
openalex   +1 more source

DNA insertion mutations can be predicted by a periodic probability function [PDF]

arXiv, 2017
It is generally difficult to predict the positions of mutations in genomic DNA at the nucleotide level. Retroviral DNA insertion is one mode of mutation, resulting in host infections that are difficult to treat. This mutation process involves the integration of retroviral DNA into the host-infected cellular genomic DNA following the interaction between
arxiv