Results 111 to 120 of about 118,257 (252)

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Discovery of Novel HIV Protease Inhibitors Using Modern Computational Techniques. [PDF]

Int J Mol Sci, 2022
Okafor SN, Angsantikul P, Ahmed H.
europepmc   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Repurposing HIV Protease Inhibitors Atazanavir and Darunavir as Antifungal Treatments against Candida albicans Infections: An In Vitro and In Vivo Study. [PDF]

Curr Issues Mol Biol, 2022
Fenley JC, de Barros PP, Carmo PHFD, Garcia MT, Rossoni RD, Junqueira JC.   +5 more
europepmc   +1 more source

Minor mutations in HIV protease at baseline and appearance of primary mutation 90M in patients for whom their first protease-inhibitor ntiretroviral regimens failed [PDF]

, 2004
The association between minor mutations in human immunodeficiency virus (HIV) protease at baseline and development of common primary mutation 90M at virological failure (conferring some resistance to all protease inhibitors [PIs]) was evaluated in 93
Antonella, D'Arminio Monforte, Balotta, Claudio, Bertoli, Ada, Cadeo, Giampiero, Chirianni, Antonio, Cozzi-Lepri, Alessandro, De Stefano, Carlo, Forbici, Federica, Mura, Maria Stella Anna, Orani, Anna, Perno, Carlo Federico, Violin, Michela   +11 more
core  

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Evaluation of Platelet Activation by HIV Protease Inhibitors - The HIV-PLA II Study. [PDF]

HIV AIDS (Auckl), 2021
Kann G, Owasil J, Kuczka K, Haberl A, Wolf T, Khaykin P, Harder S, Stephan C, von Hentig N.   +8 more
europepmc   +1 more source

Characteristics, Immunological Response & Treatment Outcomes of HIV-2 Compared with HIV-1 & Dual Infections (HIV 1/2) in Mumbai [PDF]

, 2010
Information available on HIV-2 and dual infection (HIV-1/2) is limited. This study was carried out among HIV positive individuals in an urban referral clinic in Khar, Mumbai, India, to report on relative proportions of HIV-1, HIV-2 and HIV-1/2 and ...
Alaka, Deshpande, Bhanumati, Varghese, Chiara, Montaldo, Harries, A D, Homa, Mansoor, Ladomirska, Joanna, Manzi, M, Rony, Zachariah, Wilson, N   +8 more
core   +1 more source

Effectiveness and safety of two‐drug regimens containing an integrase inhibitor and reverse transcriptase inhibitor in a cohort of virologically suppressed people with HIV: Data from the COMBINE‐2 study

HIV Medicine, EarlyView.
Abstract Objectives This study assessed real‐world effectiveness and safety of switching to dual therapy regimens consisting of an integrase inhibitor (INSTI), and reverse transcriptase inhibitor (RTI), among suppressed people living with HIV in Europe.
Cristina Mussini, Cassidy Henegar, Lambert Assoumou, Stephane de Wit, Margaret Johnson, Eugenia Quiros‐Roldan, Chris Kenyon, Colin Deschanvres, David Zucman, Frank Post, Roya Movahedi, Laura Comi, Julie Fox, Geoffrey Liegeon, Charlotte Martin, Jonathan Edwards, Giorgio Tiecco, Marc Delforge, Leigh Ragone, Bryn Jones, Jean van Wyk, Michael Aboud, Carl Fletcher, Anton Pozniak, Vani Vannappagari   +24 more
wiley   +1 more source

Psychological responses to interval and continuous exercise in people living with HIV: A single‐blind, counterbalanced, crossover study

HIV Medicine, EarlyView.
Abstract Aim This study compared acute psychological responses to a single session of low‐volume high‐intensity interval exercise (HIIE‐LV), high‐volume high‐intensity interval exercise (HIIE‐HV), and moderate‐intensity continuous exercise (MICE) in people living with HIV, and healthy controls using a randomized, counterbalanced crossover design ...
Phelipe Wilde, Victor S. de Queiros, Jason R. Jaggers, Angelo Sabag, Júlio M. Alves, Elaine Fernandes, Roberto F. C. Rocha, Paulo F. de Almeida‐Neto, Ronaldo Vagner Thomatieli‐Santos, Paulo Moreira Silva Dantas   +9 more
wiley   +1 more source