Combination antiretroviral therapy -associated lipodystrophy : insights into pathogenesis and treatment [PDF]
, 2011 Introduction: Combination antiretroviral therapy (cART) has decreased morbidity and mortality of individuals infected with human immunodeficiency virus type 1 (HIV-1). Its use, however, is associated with adverse effects which increase the patients risk
Sevastianova, Ksenia
core
Mapping protein–protein interactions by mass spectrometry
Mass Spectrometry Reviews, EarlyView.Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu +4 more
wiley +1 more source
Repurposing HIV Protease Inhibitors Atazanavir and Darunavir as Antifungal Treatments against Candida albicans Infections: An In Vitro and In Vivo Study. [PDF]
Curr Issues Mol Biol, 2022 Fenley JC +5 more
europepmc +1 more source
Mass Spectrometry Reviews, EarlyView.Abstract Cyclodepsipeptides (CDPs) represent a huge family of chemically and structurally diverse molecules with a wide ability for molecular interactions. CDPs are cyclic peptide‐related natural products made up of both proteinogenic and nonproteinogenic amino acids linked by amide and ester bonds.
Sophie Liuu +10 more
wiley +1 more source
Evaluation of Platelet Activation by HIV Protease Inhibitors - The HIV-PLA II Study. [PDF]
HIV AIDS (Auckl), 2021 Kann G +8 more
europepmc +1 more source
Inhibition of a viral enzyme by a small-molecule dimer disruptor. [PDF]
, 2009 We identified small-molecule dimer disruptors that inhibit an essential dimeric protease of human Kaposi's sarcoma-associated herpesvirus (KSHV) by screening an alpha-helical mimetic library.
Arnold, Leggy A +7 more
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Combinative interactions of a human immunodeficiency virus (HIV) Tat antagonist with HIV reverse transcriptase inhibitors and an HIV protease inhibitor [PDF]
, 1994 E. V. Connell +2 more
openalex +1 more source
A Mathematical Model for Allergic Reactions Induced by the Therapy of HIV
Mathematical Methods in the Applied Sciences, EarlyView.ABSTRACT A new mathematical model for cell evolution in HIV is introduced and studied. Delay differential equations are used to capture the dynamics of immune system cells involved in allergies, as well as the evolution of HIV viruses, infected and uninfected CD4+$$ {}^{+} $$ cells, and cytotoxic T‐lymphocytes, under specific antiretroviral therapy ...
Rawan Abdullah +3 more
wiley +1 more source
Copper(II) Inhibition of the SARS‐CoV‐2 Main Protease
Natural Sciences, EarlyView.Molecular Docking of Cu(II) Schiff‐Base Chelates to SARS‐CoV‐2 Mpro. Two distinct Cu(II) chelates (Cu(II)Lp and Cu(II)Lm) are shown docked within the active site pocket of the Mpro, interacting with key residues HIS 41 and CYS 145. ABSTRACT In an analysis of the structural stability of the coronavirus main protease (Mpro), we identified regions of the ...
Roberto A. Garza‐López +5 more
wiley +1 more source
Evaluation of Platelet Activation by HIV Protease Inhibitors – The HIV-PLA II Study
HIV/AIDS: Research and Palliative Care, 2021 Gerrit Kann,1,* Junaid Owasil,1,* Karina Kuczka,2 Annette Haberl,1 Timo Wolf,1 Pavel Khaykin,1 Sebastian Harder,2 Christoph Stephan,1 Nils von Hentig1 1HIVCENTER, Medical HIV Treatment and Research Unit, Johann Wolfgang Goethe University ...
Kann G +8 more
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