Results 151 to 160 of about 260,498 (362)

ANN-based Drug-isolate-fold-change model predicting the resistance profiles of HIV-1 protease inhibitors [PDF]

, 2022
Hüseyin Tunç, Serdar Durdağı, Murat Sarı, Seyfullah Kotil   +3 more
openalex   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Repositioning HIV protease inhibitors and nucleos(t)ide RNA polymerase inhibitors for the treatment of SARS-CoV-2 infection and COVID-19. [PDF]

Eur J Clin Pharmacol, 2021
von Hentig N.
europepmc   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

HIV‐protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO‐hybridized derivatives?

International Journal of Cancer, 2017
D. Maksimović‐Ivanić, P. Fagone, J. McCubrey, K. Bendtzen, S. Mijatović, F. Nicoletti   +5 more
semanticscholar   +1 more source

Predictors of discontinuing injectable cabotegravir/rilpivirine and virologic outcomes after resuming oral antiretroviral therapy

HIV Medicine, EarlyView.
Abstract Objective Evaluate factors associated with discontinuation of long‐acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) and describe virologic outcomes in those that returned to oral antiretroviral therapy (ART). Methods This is a retrospective cohort study at a single‐centre primary care HIV clinic.
Tali Faggiano, Jeffrey Yin, Nimish Patel, Afsana Karim, Kari Abulhosn, Laura Bamford, Lucas Hill   +6 more
wiley   +1 more source

Polypharmacy in HIV: Rethinking what counts and why it matters

HIV Medicine, EarlyView.
Abstract Polypharmacy, the concurrent use of multiple medications, presents a growing challenge in HIV care as people living with HIV age and experience earlier onset of age‐related co‐morbidities. However, how polypharmacy is defined and assessed in HIV research remains inconsistent.
Luxsena Sukumaran, Alan Winston, Catia Marzolini, Saye Khoo, Marta Boffito, Nadia Naous, Caroline A. Sabin   +6 more
wiley   +1 more source

Hyperlipidaemia - a risk factor for femoral head osteonecrosis (Legg-Calvè-Perthes-Like disease) in children with AIDS: case report

Brazilian Journal of Infectious Diseases
Although treatment of children infected with HIV with protease inhibitors has improved the survival of these patients, various adverse side effects have been reported, including metabolic abnormalities, such as hyperlipidaemia.
Paula Aguiar de Aragão, Renata B. P. Lemos, Maria Zilda Aquino, Heloísa Helena Souza Marques   +3 more
doaj   +1 more source

Additivity in the Analysis and Design of HIV Protease Inhibitors

, 2009
Robert N. Jorissen, G. Sudhakar Reddy, Akbar Ali, Michael D. Altman, Sripriya Chellappan, Saima Anjum, Bruce Tidor, Celia A. Schiffer, Tariq M. Rana, Michael K. Gilson   +9 more
openalex   +1 more source

In vitro inhibition of laam metabolism by HIV protease inhibitors [PDF]

, 1999
Barbara M. Davit, Svetlana A. Cherstniakova, Jurij Mojsiak, Louis R. Cantilena   +3 more
openalex   +1 more source