Results 221 to 230 of about 58,529 (279)

HIV protease inhibitors disrupt astrocytic glutamate transporter function and neurobehavioral performance. [PDF]

AIDS, 2016
Vivithanaporn P, Asahchop EL, Acharjee S, Baker GB, Power C.   +4 more
europepmc   +1 more source

Mechanistic Insights and Therapeutic Potentials of Ubiquitin‐Proteasome System in Non‐Small Cell Lung Cancer

Cell Proliferation, Volume 58, Issue 7, July 2025.
Lung cancer development involves mechanisms like reduced EGFR/EGF ubiquitination driving cancer cell behaviors and immune evasion via loss of PD‐1/PD‐L1 ubiquitination. Balancing ubiquitination and deubiquitination may be a potential therapeutic strategy. ABSTRACT Non‐small cell lung cancer (NSCLC) remains a leading cause of cancer mortality.
Guangyao Zhou, Jiaxiong Tan, Pengpeng Zhang, Zhaokai Zhou, Lianmin Zhang, Zhenfa Zhang   +5 more
wiley   +1 more source

Transitional changes in medication‐initiator cohort profiles in persons with chronic kidney disease and type 2 diabetes—A hospital‐based cohort study in Japan

Diabetes, Obesity and Metabolism, Volume 27, Issue 7, Page 3714-3724, July 2025.
Abstract Aims To describe temporal changes in the characteristics of medication‐initiator cohorts in persons with chronic kidney disease (CKD) and type 2 diabetes (T2D). Materials and Methods Adults with CKD and T2D initiating sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2i) or glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) were identified in ...
Yuichiro Yano, Suguru Okami, Hiroshi Kanegae, Nikolaus G. Oberprieler, Catherine Johannes, Satoshi Yamashita, Kanae Yoshikawa‐Ryan, Csaba P. Kovesdy, David Vizcaya, Naoki Kashihara   +9 more
wiley   +1 more source

Antiretroviral therapy use, self‐reported adherence, and viral suppression among women living with HIV in Canada

HIV Medicine, Volume 26, Issue 7, Page 1060-1073, July 2025.
Abstract Background Traditionally, ≥95% adherence was recommended for viral suppression (VS). Newer antiretroviral therapy (ART) is now being increasingly prescribed and may be more forgiving of lower adherence. The lifelong nature of ART presents adherence challenges, particularly for women living with HIV. We aimed to describe ART use and examine the
Maysaloun Mokaddam, Nadine Kronfli, Nancy L. Sheehan, Araceli Gonzalez Reyes, Danièle Dubuc, Mona Loutfy, Angela Kaida, Alexandra de Pokomandy, on behalf of the CHIWOS research team, Rahma Abdul‐Noor, Aranka Anema, Jonathan Angel, Dada Mamvula Bakombo, Fatimatou Barry, Greta Bauer, Kerrigan Beaver, Marc Boucher, Isabelle Boucoiran, Jason Brophy, Lori Brotto, Ann N. Burchell, Claudette Cardinal, Allison Carter, Lynne Cioppa, Tracey Conway, José Côté, Jasmine Cotnam, Cori d'Ambrumenil, Janice Dayle, Erin Ding, Danièle Dubuc, Janice Duddy, Mylène Fernet, Annette Fraleigh, Peggy Frank, Brenda Gagnier, Marilou Gagnon, Jacqueline Gahagan, Claudine Gasingirwa, Nada Gataric, Rebecca Gormley, Saara Greene, Danielle Groleau, Charlotte Guerlotté, Trevor Hart, Catherine Hankins, Emily Heer, Robert S. Hogg, Terry Howard, Shazia Islam, Joseph Jean‐Gilles, Hermione Jefferis, Evin Jones, Charu Kaushic, Mina Kazemi, Mary Kestler, Maxime Kiboyogo, Marina Klein, Nadine Kronfli, Gladys Kwaramba, Gary Lacasse, Ashley Lacombe‐Duncan, Melanie Lee, Rebecca Lee, Jenny Li, Viviane Lima, Elisa Lloyd‐Smith, Carmen Logie, Evelyn Maan, Valérie Martel‐Lafrenière, Carrie Martin, Renee Masching, Lyne Massie, Melissa Medjuck, Brigitte Ménard, Cari L. Miller, Judy Mitchell, Gerardo Mondragon, Deborah Money, Ken Monteith, Marvelous Muchenje, Florida Mukandamutsa, Mary Ndung'u, Valerie Nicholson, Kelly O'Brien, Nadia O'Brien, Gina Ogilvie, Susanna Ogunnaike‐Cooke, Joanne Otis, Rebeccah Parry, Sophie Patterson, Angela Paul, Doris Peltier, Neora Pick, Alie Pierre, Jeff Powis, Karène Proulx‐Boucher, Corinna Quan, Jesleen Rana, Eric Roth, Danielle Rouleau, Geneviève Rouleau, Sergio Rueda, Kate Salters, Margarite Sanchez, Roger Sandre, Jacquie Sas, Édénia Savoie, Paul Sereda, Stephanie Smith, Marcie Summers, Wangari Tharao, Christina Tom, Cécile Tremblay, Jason Trigg, Sylvie Trottier, Angela Underhill, Anne Wagner, Sharon Walmsley, Clara Wang, Kath Webster, Wendy Wobeser, Denise Wozniak, Mark H. Yudin, Wendy Zhang, Julia Zhu   +125 more
wiley   +1 more source

Human Alveolar Macrophages Detect SARS‐CoV‐2 Envelope Protein Through TLR2 and TLR4 and Secrete Cytokines in Response

Immunology, Volume 175, Issue 3, Page 391-401, July 2025.
Alveolar macrophages (AMs)—the most numerous immune cells of the lung—respond to viral infections by secreting cytokines to summon other immune cells. We investigated whether AMs recognize SARS‐CoV‐2 proteins and how they respond. AMs did not sense spike protein but did recognize envelope protein via the pattern recognition receptors TLR2 and TLR4 ...
Conor Grant, Emily Duffin, Finbarr O’Connell, Parthiban Nadarajan, Colm Bergin, Joseph Keane, Mary P. O'Sullivan   +6 more
wiley   +1 more source

Obesity‐Induced Metabolic Priming Exacerbates SARS‐CoV‐2 Inflammation

Immunology, Volume 175, Issue 3, Page 323-338, July 2025.
Monocytes primed under obesogenic conditions, such as increased FFA levels (i.e., palmitate) exhibit exacerbated gene expression of inflammatory cytokines. The increased proinflammatory response of palmitate‐primed and SARS‐CoV‐2‐infected monocytes is not dependent on glycolytic metabolism but instead on the entry of FFAs into the mitochondria ...
Gustavo Gastão Davanzo, Bianca Gazieri Castelucci, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, Larissa Menezes dos Reis, Isabella Bonilha de Oliveira, José Luís Fachi, João Victor Virgilio‐da‐Silva, Marcelo Rodrigues Berçot, Mariane Font Fernandes, Sarah de Oliveira, Nathalia Vitoria Pereira Araujo, Guilherme Ribeiro, Gisele de Castro, Webster Leonardo Guimarães Costa, Adriana Leandra Santoro, Gabriela Flavia Rodrigues‐Luiz, Helison Rafael P. do Carmo, Ikaro Breder, Marcelo A. Mori, Alessandro S. Farias, Daniel Martins‐de‐Souza, Joseph W. Guarnieri, Douglas C. Wallace, Marco Aurélio Ramirez Vinolo, José Luiz Proença‐Módena, Afshin Beheshti, Andrei C. Sposito, Pedro M. Moraes‐Vieira   +28 more
wiley   +1 more source

Acute liver disorders in the third trimester—AFLP, HELLP and infectious hepatitis—update on pathology, diagnosis and management

The Obstetrician &Gynaecologist, Volume 27, Issue 3, Page 180-196, July 2025.
Key content The epidemiology and pathophysiology of AFLP, HELLP syndrome and infectious viral hepatitis in late pregnancy. Clinical presentation, diagnosis and management of these conditions. Complications (maternal and fetal) and how these can be managed. The role of a multidisciplinary team in management.
Victor N. Chilaka, Mohammed Bashir, Theodore Ngatchu, Badreldeen Ahmed, Justin C. Konje   +4 more
wiley   +1 more source

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 22: Suitability of taxonomic units notified to EFSA until March 2025

EFSA Journal, Volume 23, Issue 7, July 2025.
Abstract The qualified presumption of safety (QPS) process was developed to assess the safety of microorganisms used in food and feed chains. During the period covered by this Statement, no new information warranted changes to the status of previously recommended QPS taxonomic units.
EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Pier Sandro Cocconcelli, Pablo Salvador Fernández Escámez, Miguel Prieto Maradona, Amparo Querol, Lolke Sijtsma, Juan Evaristo Suarez, Marianne Chemaly, Ingvar Sundh, Fulvio Barizzone, Justine Dastouet, Nadya Doyle, Sandra Correia, Lieve Herman   +28 more
wiley   +1 more source

Liquid Chromatography-Mass Spectrometry Metabolomic Analysis of <i>Terminalia ferdinandiana</i> Exell. Fruit Extracts That Inhibit HIV-1 Cell Infection, HIV-1 Reverse Transcriptase and HIV-1 Protease. [PDF]

Molecules
Cock IE, Matthews B, Basson AE.
europepmc   +1 more source

Enhanced HIV-1 Neutralizing Antibody Breadth in HTLV-2 Co-Infected Individuals: Influence of Antiretroviral Regimen and B Cell Subset Distribution. [PDF]

Vaccines (Basel)
Yuste E, Ruiz-De-León MJ, Casado JL, Moreno A, Vivancos MJ, Pérez-Elías MJ, Dronda F, Quereda C, Sánchez-Merino V, Vallejo A.   +9 more
europepmc   +1 more source