Results 221 to 230 of about 260,498 (362)

HIV protease inhibitors block parasite signal peptide peptidases and prevent growth of Babesia microti parasites in erythrocytes. [PDF]

Biochem Biophys Res Commun, 2019
Schwake C, Baldwin MR, Bachovchin W, Hegde S, Schiemer J, Okure C, Levin AE, Vannier E, Hanada T, Chishti AH.   +9 more
europepmc   +1 more source

L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. II. Isolation and structure.

, 1992
John G. Ondeyka, Otto D. Hensens, Deborah L. Zink, Richard Ball, R. B. Lingham, Gerald F. Bills, Anne W. Dombrowski, Michael Goetz   +7 more
openalex   +2 more sources

Effect of Combination Therapy Including Protease Inhibitors on Mortality among Children and Adolescents Infected with HIV-1 [PDF]

, 2001
Steven L. Gortmaker, Michael D. Hughes, Joseph S. Cervia, Michael T. Brady, George M. Johnson, George R. Seage, Lin Song, Wayne M. Dankner, James M. Oleske   +8 more
openalex   +1 more source

Probiotic‐Based Materials as Living Therapeutics

Advanced Materials, Volume 38, Issue 1, 2 January 2026.
Recent advances in Engineered Living Materials are highlighted, integrating synthetic biology and advanced materials, with a focus on probiotic‐based therapeutics. Probiotic Living Materials hold great potential for biosensing, infection treatment, osteogenesis, wound healing, vaginal and gastrointestinal disorders, and cancer therapy. breakthroughs in
Laura Sabio, Graham J. Day, Manuel Salmeron‐Sanchez   +2 more
wiley   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

An Assay to Monitor HIV-1 Protease Activity for the Identification of Novel Inhibitors in T-Cells

, 2010
Brett J. Hilton, Roland Wolkowicz
openalex   +2 more sources

A Conserved Hydrogen-Bonding Network of P2 bis -Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV [PDF]

, 2014
Ravikiran S. Yedidi, H. Garimella, Manabu Aoki, Hiromi Aoki-Ogata, Darshan V. Desai, Simon B. Chang, David A. Davis, W. Sean Fyvie, Joshua D. Kaufman, David W. Smith, Debananda Das, Paul T. Wingfield, Kenji Maeda, Arun K. Ghosh, Hiroaki Mitsuya   +14 more
openalex   +1 more source

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease. [PDF]

J Enzyme Inhib Med Chem, 2019
Maseko S, Padayachee E, Maphumulo S, Govender T, Sayed Y, Maguire G, Lin J, Naicker T, Baijnath S, Gerhardus KH.   +9 more
europepmc   +1 more source

HIV-1 suppression by early treatment with hydroxyurea, didanosine, and a protease inhibitor

, 1998
Julianna Lisziewicz, Heiko Jessen, Diana Finzi, Robert F. Siliciano, Franco Lori   +4 more
openalex   +1 more source