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Markers of the HIV-1 reservoir
Current Opinion in HIV and AIDS, 2018The HIV-1 reservoir is composed of infected cells poised to replicate and spread the virus upon treatment interruption. It constitutes the main obstacle toward an HIV-1 cure. Whether marker(s) may allow the detection of cells that form the reservoir is an outstanding question.
Timothée, Bruel, Olivier, Schwartz
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Nevirapine nanosuspensions for HIV reservoir targeting
Die Pharmazie, 2011In this paper we discuss, production, characterization and in-vivo evaluation of nevirapine nanosuspensions. Laser diffraction showed that the average particles size was 457 nm. Following single-dose administration, the plasma gamma concentration profiles showed fast release.
Singh, K. K., Shegokar, R.
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Viral reservoirs and HIV-specific immunity
Current Opinion in Internal Medicine, 2006HIV-1 infection is complicated by the presence of latently infected CD4 T cells as well as several anatomical reservoirs that present a barrier to eradication by current antiretroviral therapy. The early establishment of these reservoirs also presents a challenge to the development of preventive vaccines.
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Immune Interventions to Eliminate the HIV Reservoir
2017Inducing HIV remission is a monumental challenge. A potential strategy is the "kick and kill" approach where latently infected cells are first activated to express viral proteins and then eliminated through cytopathic effects of HIV or immune-mediated killing.
Denise C, Hsu, Jintanat, Ananworanich
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In Vivo Dynamics of the Latent Reservoir for HIV-1: New Insights and Implications for Cure
Annual Review of Pathology: Mechanisms of Disease, 2022Janet D Siliciano, Robert F Siliciano
exaly