Results 181 to 190 of about 36,601 (210)

HIV reservoirs

AIDS, 2012
Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved.
Tae-Wook, Chun, Anthony S, Fauci
openaire   +2 more sources

Quantification of the reservoir of HIV-1

Trends in Microbiology, 1997
germinal centres can be differentiated by the type of in situ signal seen: infected mononuclear cells give a localized signal over a single cell, and trapped virions give a diffuse signal over germinal centres. The use of radioactive probes allows an estimate of viral copy number to be made (calculated using the specific activity of the probe, the ...
openaire   +2 more sources

Mechanisms of HIV persistence in HIV reservoirs

Reviews in Medical Virology, 2017
SummaryThe establishment and maintenance of HIV reservoirs that lead to persistent viremia in patients on antiretroviral drugs remains the greatest challenge of the highly active antiretroviral therapy era. Cellular reservoirs include resting memory CD4+ T lymphocytes, implicated as the major HIV reservoir, having a half‐life of approximately 44 months
Mayibongwe L. Mzingwane, Caroline T. Tiemessen   +1 more
openaire   +3 more sources

In vitro modeling of the HIV-macrophage reservoir

Journal of Leukocyte Biology, 2006
Abstract Macrophages are recognized as a putative reservoir for HIV-1, but whether HIV can establish latent infection in this cell type is not known. An in vitro model using long-term cultured primary human monocyte-derived macrophages (MDM) infected with an M-tropic, enhanced green fluorescent protein (EGFP) tagged reporter virus was ...
Amanda, Brown, Hao, Zhang, Peter, Lopez, Carlos A, Pardo, Suzanne, Gartner   +4 more
openaire   +2 more sources

Markers of the HIV-1 reservoir

Current Opinion in HIV and AIDS, 2018
The HIV-1 reservoir is composed of infected cells poised to replicate and spread the virus upon treatment interruption. It constitutes the main obstacle toward an HIV-1 cure. Whether marker(s) may allow the detection of cells that form the reservoir is an outstanding question.
Timothée, Bruel, Olivier, Schwartz
openaire   +2 more sources

Immune control of HIV-1 reservoirs

Current Opinion in HIV and AIDS, 2013
To discuss the recent major advances in the understanding of how host immune defenses contribute to HIV reservoir control.Immune control of HIV-1 reservoirs is a two-step process: viral replication activation from latent reservoirs followed by elimination of virus-expressing cells by the host.
Brigitte, Autran, Benjamin, Descours, Charline, Bacchus   +2 more
openaire   +2 more sources

Immune Interventions to Eliminate the HIV Reservoir

2017
Inducing HIV remission is a monumental challenge. A potential strategy is the "kick and kill" approach where latently infected cells are first activated to express viral proteins and then eliminated through cytopathic effects of HIV or immune-mediated killing.
Denise C, Hsu, Jintanat, Ananworanich
openaire   +2 more sources

Viral reservoirs and HIV-specific immunity

Current Opinion in Internal Medicine, 2006
HIV-1 infection is complicated by the presence of latently infected CD4 T cells as well as several anatomical reservoirs that present a barrier to eradication by current antiretroviral therapy. The early establishment of these reservoirs also presents a challenge to the development of preventive vaccines.
openaire   +2 more sources

HIV Reservoirs

2022
openaire   +1 more source

Longitudinal clonal dynamics of HIV-1 latent reservoirs measured by combination quadruplex polymerase chain reaction and sequencing

Proceedings of the National Academy of Sciences of the United States of America, 2022
Tae-Wook Chun, Alice Cho, Christian Gaebler   +2 more
exaly