Results 171 to 180 of about 35,308 (213)
Frontiers in Cellular and Infection Microbiology, 2022 The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV is unable to be recognized by the body’s immune system. Currently, the widely adopted antiretroviral therapy (ART) is also unble to eliminate it, thus hindering the ...
Chuanyun Li, Chen Dexi
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Peering into the HIV reservoir [PDF]
Reviews in Medical Virology, 2018 SummaryThe main obstacle to HIV eradication is the establishment of a long‐term persistent HIV reservoir. Although several therapeutic approaches have been developed to reduce and eventually eliminate the HIV reservoir, only a few have achieved promising results.
Marcial Garcia +2 more
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Measuring the HIV-1 reservoir [PDF]
Nature Reviews Microbiology, 2019 The description of a method to measure the HIV-1 reservoir that quantifies intact and defective proviruses.
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Biotechnology and Genetic Engineering Reviews, 2018
Impressive advances have been made in the treatment and management of HIV-1 infected individuals. Combination antiretroviral therapy (cART) has turned HIV-1 infection from an almost invariable deadly infectious disease, to a lifelong manageable infectious disease. However, a cure or vaccine has not been forthcoming.
Guido, van Marle +3 more
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Impressive advances have been made in the treatment and management of HIV-1 infected individuals. Combination antiretroviral therapy (cART) has turned HIV-1 infection from an almost invariable deadly infectious disease, to a lifelong manageable infectious disease. However, a cure or vaccine has not been forthcoming.
Guido, van Marle +3 more
openaire +2 more sources
Understanding HIV Compartments and Reservoirs
Current HIV/AIDS Reports, 2014The spectrum of HIV-1 cellular reservoirs is highly diversified, and their role varies according to the milieu of the anatomical sites in which the virus replicates. In this light, mechanisms underlying HIV-1 persistence in anatomical compartments may be profoundly different from what is observed in peripheral blood.
SVICHER, VALENTINA +4 more
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Astrocytes as an HIV Reservoir: Mechanism of HIV Infection
Current HIV Research, 2016If we have any hope of achieving a cure for HIV infection, close attention to the cell types capable of getting infected with HIV is necessary. Of these cell types, astrocytes are the most ideal cell type for the formation of such a reservoir. These are long-lived cells with a very low turnover rate and are found in the brain and the gastrointestinal ...
Lisa Henderson, Avindra Nath
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Current Opinion in Infectious Diseases, 1999
Combination therapy for HIV-1 infection can reduce viremia to undetectable levels, suggesting that prolonged treatment might eradicate the infection. However, one potential mechanism for viral persistence involves the establishment of a state of latent infection.
J, Blankson, D, Persaud, R F, Siliciano
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Combination therapy for HIV-1 infection can reduce viremia to undetectable levels, suggesting that prolonged treatment might eradicate the infection. However, one potential mechanism for viral persistence involves the establishment of a state of latent infection.
J, Blankson, D, Persaud, R F, Siliciano
openaire +2 more sources
HIV Reservoirs and Strategies for Eradication
Current HIV/AIDS Reports, 2012Combination antiretroviral therapy (cART) has led to a reduction in morbidity and mortality in HIV-infected patients but therapy is lifelong and there is no cure for HIV. The major barriers to cure include HIV latency, which has been identified in different T-cell subsets, as well as persistence of HIV in anatomical reservoirs.
Smith, MZ, Wightman, F, Lewin, SR
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