Results 171 to 180 of about 35,436 (198)
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The prostate as a reservoir for HIV-1
AIDS, 2004As the prostate can harbor bacterial and fungal pathogens, it was investigated as a reservoir for HIV. Nine men chronically infected with HIV participated in a crossover trial in which weekly semen samples were collected with and without previous prostate massage (PM).
Davey M, Smith +5 more
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AIDS, 2012
Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved.
Tae-Wook, Chun, Anthony S, Fauci
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Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved.
Tae-Wook, Chun, Anthony S, Fauci
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Quantification of the reservoir of HIV-1
Trends in Microbiology, 1997germinal centres can be differentiated by the type of in situ signal seen: infected mononuclear cells give a localized signal over a single cell, and trapped virions give a diffuse signal over germinal centres. The use of radioactive probes allows an estimate of viral copy number to be made (calculated using the specific activity of the probe, the ...
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Mechanisms of
SummaryThe establishment and maintenance of HIV reservoirs that lead to persistent viremia in patients on antiretroviral drugs remains the greatest challenge of the highly active antiretroviral therapy era. Cellular reservoirs include resting memory CD4+ T lymphocytes, implicated as the major HIV reservoir, having a half‐life of approximately 44 months
Mayibongwe L. Mzingwane +1 more
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Immune control of HIV-1 reservoirs
Current Opinion in HIV and AIDS, 2013To discuss the recent major advances in the understanding of how host immune defenses contribute to HIV reservoir control.Immune control of HIV-1 reservoirs is a two-step process: viral replication activation from latent reservoirs followed by elimination of virus-expressing cells by the host.
Brigitte, Autran +2 more
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Markers of the HIV-1 reservoir
Current Opinion in HIV and AIDS, 2018The HIV-1 reservoir is composed of infected cells poised to replicate and spread the virus upon treatment interruption. It constitutes the main obstacle toward an HIV-1 cure. Whether marker(s) may allow the detection of cells that form the reservoir is an outstanding question.
Timothée, Bruel, Olivier, Schwartz
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Nevirapine nanosuspensions for HIV reservoir targeting
Die Pharmazie, 2011In this paper we discuss, production, characterization and in-vivo evaluation of nevirapine nanosuspensions. Laser diffraction showed that the average particles size was 457 nm. Following single-dose administration, the plasma gamma concentration profiles showed fast release.
Singh, K. K., Shegokar, R.
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Viral reservoirs and HIV-specific immunity
Current Opinion in Internal Medicine, 2006HIV-1 infection is complicated by the presence of latently infected CD4 T cells as well as several anatomical reservoirs that present a barrier to eradication by current antiretroviral therapy. The early establishment of these reservoirs also presents a challenge to the development of preventive vaccines.
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In Vivo Dynamics of the Latent Reservoir for HIV-1: New Insights and Implications for Cure
Annual Review of Pathology: Mechanisms of Disease, 2022Janet Siliciano, Robert Siliciano
exaly