Results 111 to 120 of about 73,667 (245)

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, Volume 101, Issue 4, Page 1877-1903, August 2026.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

HIV-1 reverse transcriptase dimerization is critical for enzyme function and maturation [PDF]

, 2005
HIV-1 reverse transcriptase dimerization is critical for enzyme function and ...
S Sonza (13719724), N Sluis-Cremer (13717387), G Tachedjian (13711351), J Wapling (13503850), J Radzio (13719721), Johnson Mak (13082904), K Moore (9720572)   +6 more
core  

The HIV-1 Subtype C Epidemic in South America Is Linked to the United Kingdom [PDF]

, 2010
Background: The global spread of HIV-1 has been accompanied by the emergence of genetically distinct viral strains. Over the past two decades subtype C viruses, which predominate in Southern and Eastern Africa, have spread rapidly throughout parts of ...
Gifford, RJ, Gifford Robert J., Pillay Deenan, Pillay, D, Tulio de Oliveira, UK Collaborative Grp HIV Drug Resi, Robert J Gifford, Deenan Pillay, de Oliveira, T, UK Collaborative Group on HIV Drug Resistance, de Oliveira Tulio   +10 more
core   +1 more source

Assessing subtypes and drug resistance mutations among HIV-1 infected children who failed antiretroviral therapy in Kelantan, Malaysia

Brazilian Journal of Infectious Diseases, 2012
Antiretroviral (ARV) therapy has dramatically reduced morbidity and mortality in human immunodeficiency virus 1 (HIV-1) infected children. However, development of ARV resistance in these children is a major public health problem due to lack of ...
Suharni Mohamad, Zakuan Zainy Deris, Nik Khairulddin Yusoff, Tg Ahmad Akram Tg Mohd Ariffin, Rafidah Hanim Shueb   +4 more
doaj   +1 more source

Humoral and cellular responses to SARS‐CoV‐2 variants after ancestral COVID‐19 vaccines in people with HIV and lung transplant recipients

Clinical &Translational Immunology, Volume 15, Issue 8, 2026.
This study compares the humoral and cellular immunogenicity of Dose 3 of Ancestral SARS‐CoV‐2 vaccine in participants with HIV and/or following lung transplantation with healthy controls. We highlight differences along a spectrum of immunocompromise, and the value of SARS‐CoV‐2 vaccination, even in the absence of detectable neutralisation responses ...
David WJ Griffin, Paul A Gill, Irene Boo, Shir Sun, Raffi Gugasyan, Alina Wang, Scott J Bornheimer, Stuart Turville, Anupriya Aggarwal, Greg I Snell, Glen P Westall, Emily SJ Edwards, Anna Coldham, Menno C van Zelm, Heidi E Drummer, James H McMahon   +15 more
wiley   +1 more source

Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription. [PDF]

, 2004
The increasing numbers of human immunodeficiency virus type 1 (HIV-1) strains that exhibit resistance to antiretroviral agents used at present require the development of new effective antiretroviral compounds.
Bates, Paula J, B. R. Kosloff, Priebe, W, G. M. Shaw, Kosloff, Barry R, W. Priebe, Levy, David N, O. Kutsch, P. J. Bates, Shaw, George M, Kutsch, Olaf, Benveniste, Etty N, E. N. Benveniste, Decker, Julie, D. N. Levy, J. Decker   +15 more
core   +1 more source

Single‐Nucleus Multiomic Analysis Reveals Immune–Metabolic Reprogramming Consistent With Maladaptive Trained Immunity in HIV‐Associated Neurocognitive Disorders

Glia, Volume 74, Issue 8, August 2026.
Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez, Anelia Horvath, Luke Johnson, Tatiana Pushkarsky, Larisa Dubrovsky, Daria Starosyla, Ashley Bastin, Dmitri Sviridov, Michael Bukrinsky   +8 more
wiley   +1 more source

Targeted Interventions in HAM/TSP: Emerging Therapies and Future Directions – A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aim Human T‐Lymphotropic virus type 1 (HTLV‐1) infection can lead to HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), a debilitating chronic neurological disease characterized by progressive lower limb spasticity and autonomic dysfunction.
Meygol Mirzaei Rezaei, Mahdi Khosravi Nia, Kasra Allaei Rouzbahani, Maryam Kazemi, Negar Asghari Hosori, Mehdi Norouzi, Farzaneh Sotoudegan, Narges Eslami, Negar Ariamand, Vahid Shahnavaz, Arash Letafati, Sayed‑Hamidreza Mozhgani   +11 more
wiley   +1 more source

The influence of APOBEC3G and deoxythymidylate kinase genetic diversity on HIV-1 hypermutation and response to treatment [PDF]

, 2006
This thesis addresses two important topics in HIV-1 medicine; (i) the clinical relevance of pre-treatment G-A hypermutation and the contribution of host and viral genetics to its development and; (ii) the influence of genetic variation in host enzymes ...
Pace, Craig Stuart
core   +1 more source

Phylogenetic surveillance of viral genetic diversity and the evolving molecular epidemiology of human immunodeficiency virus type 1 [PDF]

, 2007
With ongoing generation of viral genetic diversity and increasing levels of migration, the global human immunodeficiency virus type 1 (HIV-1) epidemic is becoming increasingly heterogeneous.
Vandamme, Anne-Mieke, ?, ?, Kellam, Paul, Pillay, Deenan, Rambaut, Andrew, Gifford, Robert J., de Oliveira, Tulio, Pybus, Oliver G., Dunn, David   +8 more
core   +1 more source