Results 121 to 130 of about 1,155,481 (241)
Transmitted drug resistance in patients with acute/recent HIV infection in Brazil
Introduction: The widespread use of antiretroviral therapy increased the transmission of antiretroviral resistant HIV strains. Antiretroviral therapy initiation during acute/recent HIV infection limits HIV reservoirs and improves immune response in HIV ...
Ana Cristina G. Ferreira +7 more
doaj +1 more source
Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis. [PDF]
de Leon VNO +8 more
europepmc +1 more source
Abstract Cisgender women face an increased risk of HIV acquisition during pregnancy and postpartum. Oral pre‐exposure prophylaxis (PrEP) with emtricitabine and tenofovir disoproxil fumarate (F/TDF) is recommended in pregnancy despite limited published pharmacokinetic (PK) and efficacy data during pregnancy.
Yifan Yu +17 more
wiley +1 more source
The influence of APOBEC3G and deoxythymidylate kinase genetic diversity on HIV-1 hypermutation and response to treatment [PDF]
This thesis addresses two important topics in HIV-1 medicine; (i) the clinical relevance of pre-treatment G-A hypermutation and the contribution of host and viral genetics to its development and; (ii) the influence of genetic variation in host enzymes ...
Pace, Craig Stuart
core
ABSTRACT Introduction In non‐pregnant adults living with HIV, dolutegravir is associated with weight gain and increased type 2 diabetes risk. In pregnancy, data on the effect of dolutegravir on gestational diabetes (GDM) risk is inconclusive. Data are particularly limited in Asian populations, where diabetes risk is especially high and not always ...
Puja Chebrolu +13 more
wiley +1 more source
ABSTRACT Introduction The BREATHER‐Plus trial was an open‐label, randomized non‐inferiority trial comparing weekends off antiretroviral therapy (ART) (short cycle therapy [SCT]) with daily oral ART (continuous therapy [CT]) for adolescents aged 12–19 years. We present findings from the qualitative sub‐study on the factors influencing trial participants’
Londiwe Shandu +11 more
wiley +1 more source
Antiretoviral therapy and the lipodystrophy syndrome, part 2: Concepts in aetiopathogenesis [PDF]
Clinical research has indicated that the use of nucleoside reverse transcriptase inhibitor (NRTI) and HIV protease inhibitor (PI) therapy is associated with a risk of long-term toxicity syndromes, and that the aetiopathogenesis of these adverse effects ...
Nolan, D., John, M., Mallal, S.
core
High‐Content CRISPR Screening: Methods and Applications
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang +6 more
wiley +1 more source
HIV-1 Drug Resistance mutations against nucleotide reverse transcriptase inhibitors (NRTI), non-nucleotide reverse transcriptase inhibitors (NNRTI) and protease inhibitors (PI) identified by the ATCC assay versus the ViroSeq assay for those individual ...
Okpokwu Jonathan (5464964) +19 more
core +1 more source

