Results 11 to 20 of about 73,667 (245)

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration [PDF]

, 2005
Background The genetic differences among HIV-1 subtypes may be critical to clinical management and drug resistance surveillance as antiretroviral treatment is expanded to regions of the world where diverse non-subtype-B viruses predominate.Methods and ...
Wynhoven, B, Cane, P, Holguin, A, Pedro Cahn, Maria Belen Bouzas, Africa Holguin, Luis F Brigido, Sirivichayakul, S, Anne-Mieke Vandamme, Camacho, R, Efron, B, Koya Ariyoshi, Grossman, Z, Robert W Shafer, Shafer, RW, Bouzas, MB, Brian Wynhoven, Ricardo Camacho, Jonathan N Weber, Harrigan, PR, Ariyoshi, K, Ana Patricia Carvalho, Rosangela Rodrigues, Rudich, H, Candice Pillay, Soares, MA, Katzenstein, DA, Vandamme, AM, Clarke, J, Lynn Morris, Snoeck, J, Soriano, V, Rodrigues, R, Brigido, LF, Wataru Sugiura, Praphan Phanuphak, Kantor, R, Sugiura, W, John Clarke, Jonathan M Schapiro, Rami Kantor, David A Katzenstein, Carvalho, AP, P Richard Harrigan, Patricia Cane, Phanuphak, P, Brad Efron, Pillay, D, Pillay, C, Sunee Sirivichayakul, Joke Snoeck, Cahn, P, Hagit Rudich, Schapiro, JM, Morris, L, Zehava Grossman, Amilcar Tanuri, Tanuri, A, Weber, JN, Vincent Soriano, Deenan Pillay, Marcelo A Soares   +61 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]

, 2013
HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
core   +1 more source

Docking Study of HIV-1 Reverse Transcriptase (HIV-1 RT) with Well-Known Nucleoside Reverse Transcriptase Inhibitors (NRTIs) [PDF]

Journal of Advanced Pharmacy Research
Objectives: The nucleic acid-binding cleft in HIV-1 reverse transcriptase (HIV-1 RT) is essential because of its interactions with the polymerase and RNase H active sites. Studying its binding sites for nucleoside reverse transcriptase inhibitors (NRTIs)
Roohallah Yousefi
doaj   +1 more source

HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors [PDF]

Journal of Virology, 2012
ABSTRACT As anti-HIV therapy becomes more widely available in developing nations, it is clear that drug resistance will continue to be a major problem. The related viruses HIV-1 and HIV-2 share many of the same resistance pathways to nucleoside reverse transcriptase inhibitors (NRTIs).
Paul L, Boyer, Patrick K, Clark, Stephen H, Hughes   +2 more
openaire   +2 more sources

Impact of the N348I Mutation in HIV-1 Reverse Transcriptase on Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Non-Subtype B HIV-1 [PDF]

, 2011
We investigated the effect of N348I alone and with M184V on nonnucleoside reverse transcriptase inhibitor (NNRTI) drug susceptibility and replicative capacity in B and non-B HIV-1 isolates.
Michael Chirara, Cissy Kityo, Kaleebu, P., Pontiano Kaleebu, Pillay, D., Greg J. Towers, Crombe, A., Towers, G.J., Kityo, C., Adele L. McCormick, Chirara, M., Ravindra K. Gupta, Gupta, R.K., Goodall, R.L., Chris M. Parry, Anne Crombe, Ruth L. Goodall, Deenan Pillay, Parry, C.M., McCormick, A.L.   +19 more
core   +1 more source

Rational in silico drug design of HIV-RT inhibitors through G-QSAR and molecular docking study of 4-arylthio and 4-aryloxy-3-iodopyridine-2(1-H)-one derivative

Beni-Suef University Journal of Basic and Applied Sciences, 2020
Background Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV).
Debadash Panigrahi, Amiyakanta Mishra, Susanta Kumar Sahu   +2 more
doaj   +1 more source

Phenotypic and genotypic analyses to guide selection of reverse transcriptase inhibitors in second-line HIV therapy following extended virological failure in Uganda. [PDF]

, 2014
We investigated phenotypic and genotypic resistance after 2 years of first-line therapy with two HIV treatment regimens in the absence of virological ...
Awio, P., Munderi, P., Pillay, D., Ndembi, N., Nkurunziza, P., Ndembi, N, Pattery, T, Dunn, DT, van Cauwenberge, A, Gilks, C. F., Gilks, CF, Awio, P, Munderi, P, Nkurunziza, P, Kaleebu, P., Pillay, D, Goodall, RL, DART Virology Group and Trial Teams, Kaleebu, P, Goodall, R. L., Kityo, C., Dunn, D. T., Kityo, C, Pattery, T., van Cauwenberge, A.   +24 more
core   +1 more source

High-level resistance to non-nucleos(t)ide reverse transcriptase inhibitor based first-line antiretroviral therapy in Ghana; A 2017 study

Frontiers in Microbiology, 2022
Expanding access to effective antiretroviral therapy (ART) is a major tool for management of Human Immunodeficiency Virus (HIV) infection. However, rising levels of HIV drug-resistance have significantly hampered the anticipated success of ART in persons
Prince Kofi Parbie, Christopher Zaab-Yen Abana, Christopher Zaab-Yen Abana, Christopher Zaab-Yen Abana, Dennis Kushitor, Theodore Worlanyo Asigbee, Theodore Worlanyo Asigbee, Nana Afia Asante Ntim, Nana Afia Asante Ntim, Gifty Addo-Tetebo, Maclean Richard Darko Ansong, Sampson Badu Ofori, Taketoshi Mizutani, Lucky Ronald Runtuwene, Masako Nishizawa, Koichi Ishikawa, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, William Kwabena Ampofo, Tetsuro Matano, Tetsuro Matano, Tetsuro Matano, Evelyn Yayra Bonney, Tadashi Kikuchi   +24 more
doaj   +1 more source