Results 31 to 40 of about 1,155,481 (241)

Synthesis of Quinolin-2-one Alkaloid Derivatives and Their Inhibitory Activities against HIV-1 Reverse Transcriptase

Molecules, 2011
Based on an established common pharmacophore of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNTTIs), a series of quinolin-2-one derivatives were synthesized and assayed for their in vitro activities against HIV-1 reverse transcriptase (RT) for
Pi Cheng, Qiong Gu, Wei Liu, Jian-Feng Zou, Yang-Yong Ou, Zhong-Yong Luo, Jian-Guo Zeng   +6 more
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals:the relative roles of drift and selection [PDF]

, 2000
Human immunodeficiency virus type 1 (HIV-1) rapidly develops resistance to lamivudine during monotherapy, typically resulting in the appearance at position 184 in reverse transcriptase (RT) of isoleucine instead of the wild-type methionine (M184I) early ...
Frost, SDW, Boucher, CAB, Leigh Brown, AJ, Nijhuis, M, Schuurman, R   +4 more
core   +1 more source

Adaptation to Different Human Populations by HIV-1 Revealed by Codon-Based Analyses [PDF]

, 2006
Several codon-based methods are available for detecting adaptive evolution in protein-coding sequences, but to date none specifically identify sites that are selected differentially in two populations, although such comparisons between populations have ...
Gravenor Michael B, Kosakovsky Pond, Sergei L., Sergei L Kosakovsky Pond, Michael B Gravenor, Michael Gravenor, Douglas D Richman, Frost Simon D. W, Richman Douglas D, Brown Andrew J. Leigh, Simon D W Frost, Zehava Grossman, Kosakovsky Pond Sergei L, Leigh Brown, Andrew J., Gravenor, Michael B., Andrew J Leigh Brown, Grossman, Z., Richman, D. D., Frost, S. D. W., Grossman Zehava   +18 more
core   +2 more sources

Selected Milestones in Antiviral Drug Development

Viruses
This review article will describe the (wide) variety of approaches that I envisaged to develop a specific therapy for viral infections: (i) interferon and its inducers, (ii) HSV, VZV and CMV inhibitors, (iii) NRTIs (nucleoside reverse transcriptase ...
Erik De Clercq
doaj   +1 more source

Investigational reverse transcriptase inhibitors for the treatment of HIV [PDF]

Expert Opinion on Investigational Drugs, 2015
While considerable advances have been made in the development of antiretroviral agents, there is still work to be done. Reverse transcriptase inhibitors are important drugs for the treatment of HIV, and considerable research is currently ongoing to develop new agents and to modify currently existing agents.Herein, the authors discuss both ...
Theodore J, Cory, Narasimha M, Midde, Pss, Rao, Santosh, Kumar   +3 more
openaire   +2 more sources

Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing. [PDF]

, 2013
BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary focus of this work was to characterize
Grace P McCormack, Crampin, Amelia C., Bansode, Vijay, McCormack, Grace P., Glynn, Judith R., Neil French, Ram K Shrestha, Travers, Simon A, Simon A Travers, French, Neil, Glynn, Judith R, Crampin, Amelia C, Vijay Bansode, Judith R Glynn, Vijay Bansode, Amelia C Crampin, McCormack, Grace P, Travers, Simon A., Shrestha, Ram K., Ngwira, Bagrey, Shrestha, Ram K, Bagrey Ngwira, Bansode Vijay, French Neil, Ngwira Bagrey, Crampin Amelia C, McCormack Grace P, Travers Simon A, Glynn Judith R, Shrestha Ram K   +29 more
core   +2 more sources

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants

Retrovirology, 2012
Background The recently approved anti-AIDS drug rilpivirine (TMC278, Edurant) is a nonnucleoside inhibitor (NNRTI) that binds to reverse transcriptase (RT) and allosterically blocks the chemical step of DNA synthesis.
Johnson Barry C, Pauly Gary T, Rai Ganesha, Patel Disha, Bauman Joseph D, Baker Heather L, Das Kalyan, Schneider Joel P, Maloney David J, Arnold Eddy, Thomas Craig J, Hughes Stephen H   +11 more
doaj   +1 more source

Strategies in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

Viruses, 2023
AIDS (acquired immunodeficiency syndrome) is a potentially life-threatening infectious disease caused by human immunodeficiency virus (HIV). To date, thousands of people have lost their lives annually due to HIV infection, and it continues to be a big ...
Murugesan Vanangamudi, Senthilkumar Palaniappan, Muthu Kumaradoss Kathiravan, Vigneshwaran Namasivayam   +3 more
doaj   +1 more source

Nucleoside reverse transcriptase inhibitors and HIV mutagenesis [PDF]

Journal of Antimicrobial Chemotherapy, 2003
Potent antiretroviral therapy (ART) of HIV-1 infection with anti-retroviral drugs consisting of nucleoside reverse transcriptase inhibitors(NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs)and protease inhibitors (PIs) has dramatically reduced the rate ofHIV- and AIDS-related morbidity and mortality. The lack of patientcompliance to drug
Nancy A, Jewell, Renxiang, Chen, Raquel, Raices, Louis M, Mansky   +3 more
openaire   +2 more sources