Results 21 to 30 of about 82 (80)

HLA-B*27 in human health and disease

Romanian Journal of Rheumatology, 2019
HLA-B*27 is one of the most studied HLA allele due to its association with diseases from the spondyloarthritis group, mainly ankylosing spondylitis. This association is still the strongest association described in the literature between an HLA gene and a disease.
Silvia Ioana Andrei, Dan Denis Boloca, Olivia Mihaela Popa, Constantin Bara   +3 more
openaire   +2 more sources

FRI0634 Cost savings of using hla-b*27 tag snp genotyping to determine hla-b*27 status in a canadian population [PDF]

Annals of the Rheumatic Diseases, 2018
Background: HLA-B*27 is a useful genetic marker for screening axSpA [1,2] to determine who can benefit from rheumatologic evaluation in a primary care setting [3]. Currently, entire HLA-B locus tests are the gold standard for determining HLA-B*27 status but they are expensive. With a sensitivity of 97.6%, the cheaper HLA-B*27 tag-SNP assay could offer
S. Mital, D. O'Rielly, H.V. Nguyen, P. Rahman   +3 more
openaire   +1 more source

A Homogeneous HLA‐B*27 Genotyping Assay Using Dried Reagent Mixtures

Disease Markers, Volume 27, Issue 2, Page 85-91, 2009., 2009
The presence of HLA‐B*27 allele with patients suspected with ankylosing spondylitis can be used in the diagnostic process. We have developed an assay for typing for the HLA‐B*27 in whole blood dried on sample collection cards using pre‐dried reagent wells and homogeneous time‐resolved fluorescence based PCR approach.
Minna Kiviniemi, Jorma Ilonen, Timo Lövgren   +2 more
wiley   +1 more source

HLA‐B27 Determination by Polymerase Chain Reaction

Disease Markers, Volume 12, Issue 4, Page 247-251, 1996., 2013
A method for determining the presence or absence of HLA‐827 by selective amplification of a region in the third exon of the HLA‐B27 gene common to B*270 I to B*2705 inclusive, was evaluated. This polymerase chain reaction/sequence specific primer (PCR‐SSP) method gave perfect correlation with serological typing on 40 individuals of previously ...
D. C. Kilpatrick
wiley   +1 more source

Genetics in Ankylosing Spondylitis – Beyond HLA-B*27 [PDF]

, 2012
Bruno Filipe Bettencourt1,3, Iris Foroni1,3, Ana Rita Couto1,3, Manuela Lima2,3 and Jacome Bruges-Armas1,3 1Servico Especializado de Epidemiologia e Biologia Molecular, Hospital de Santo Espirito de Angra do Heroismo 2Grupo de Epidemiologia e Genetica Humana do Departamento de Biologia da Universidade dos Acores 3Genetic and Arthritis Research Group ...
Bruno Filipe, Iris Foroni, Ana Rita, Manuela Lima, Jcome Bruges-Armas   +4 more
openaire   +1 more source

The Art of Deception: Multiple Myeloma Imitating Spondyloarthritis—A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Rheumatic symptoms can be associated with malignancies. Although sacroiliitis is not a classic paraneoplastic syndrome, malignant infiltration of sacroiliac joints by multiple myeloma can mimic inflammatory rheumatologic disease. Multiple myeloma (MM), a plasma cell malignancy often presenting with bone pain, can involve axial skeletal ...
Prabin Khatri, Aabishkar Subedi, Bishad Dahal, Gibson Shrestha, Mandish Phuyal, Raj Adhikari   +5 more
wiley   +1 more source

Exhaustion‐Resistant CD8 + T Cells in Ankylosing Spondylitis: A Proposed Three‐Axis Model

Immunology, Volume 176, Issue 4, Page 409-420, December 2025.
Exhaustion‐resistant CD8+ T cells may sustain ankylosing spondylitis. A three‐axis model—intermittent T‐cell receptor engagement, IL‐15/CD28 co‐stimulation and maintained metabolic fitness—explains how PD‐1^high CD8+ T cells retain effector function and accumulate from gut to entheses, promoting inflammation and aberrant bone remodelling.
Xuhong Zhang, Lu Jia, Xueni Lin, Lamei Zhou   +3 more
wiley   +1 more source

Seasonal Variation in HLA‐B27 Associated Uveitis

Clinical &Experimental Ophthalmology, Volume 53, Issue 5, Page 516-522, July 2025.
ABSTRACT Background To examine if there was a monthly variation in HLA‐B27‐associated uveitis. Methods Retrospective review of all individuals presenting to a single centre with HLA‐B27‐associated uveitis from 2009 to 2020. Results 577 participants with HLA‐B27‐associated uveitis were included. The median age at presentation was 40.4 years (IQR 31.1–51.
Priya D. Samalia, James Brodie, Joanne L. Sims, Rachael L. Niederer   +3 more
wiley   +1 more source

Converting an HLA‐B27 flow assay from the BD FACSCanto to the BD FACSLyric

Cytometry Part B: Clinical Cytometry, Volume 108, Issue 1, Page 67-76, January 2025.
Abstract HLA‐B27 is a major histocompatibility complex (MHC) class I antigen which exhibits strong association (90%) with ankylosing spondylitis. HLA‐B27 detection in patients by flow cytometry is a widely used clinical test, performed on many different flow cytometer models.
Eugene V. Ravkov, Miguel F. Ventura, Swapna Gudipaty, David Ng, Julio C. Delgado, Leo Lin   +5 more
wiley   +1 more source

Human Leukocyte Antigen - HLA B*27: Unraveling the Link to Pathogenesis

Indian Journal of Rheumatology, 2020
The association of spondyloarthritis (SpA) with human leukocyte antigen-B*27 (HLA-B*27) is one of the strongest known for a non-monogenic disease. How HLA-B*27 determines the aetiopathogenesis of SpA and disposes toward this group of disease has perplexed rheumatologists for decades.
Sakir Ahmed, Ramnath Misra
openaire   +2 more sources