Results 141 to 150 of about 16,215 (178)

HLA-B27 Is Necessary But Not Sufficient

Scandinavian Journal of Rheumatology, 1990
It is discussed why some, but not all HLA-B27-positive persons get disease when triggered by certain infections. The conclusions are that a possible modifying gene may be found on the other HLA haplotype or outside the HLA complex. Given an epidemic infection afflicting a family, it is the possible differences of other environmental factors which may ...
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THE ROLE OF HLA-B27 IN ARTHRITIS

Rheumatology, 1988
We postulate (Table I) that ReA is an antigen or immune complex induced condition caused by chronic intracellular bacterial infection at a distant site. The main predisposing factor is a failure to resist this infection. If the bacteria happen to carry MF, the inflammation is exacerbated in B27 positive patients.
J R, Archer, V R, Winrow, I L, McLean
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HLA-B27 and pathogenesis of spondyloarthropathies

Current Opinion in Rheumatology, 2002
Although the influence of HLA-B27 on the development of spondyloarthropathies is undisputed, its role in pathogenesis remains unclear. New ideas have focused on abnormal characteristics of HLA-B27 resulting from aberrant folding, disulfide bond formation, or both, rather than a predilection for selecting arthritogenic peptides.
Matthew J, Turner, Robert A, Colbert
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HLA-B27 as a receptor for cytomegalovirus

Current Eye Research, 1992
Acute anterior uveitis (AAU) is strongly associated with the genetic marker and cell membrane protein HLA-B27. Although also other genetic factors must play a pathogenetic role, the HLA-class I molecule B27 is up to now the only hold. The normal task of HLA class I molecules is to present endogenous, mostly viral, peptides to receptors on cytotoxic T ...
M F, Beersma, M J, Bijlmakers, J L, Geelen, T E, Feltkamp   +3 more
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Outcomes of HLA-B27-Positive and HLA-B27-Negative Acute Anterior Uveitis

American Journal of Ophthalmology, 1995
Outcomes of HLA-B27-positive and HLA-B27-negative acute anterior uveitis were assessed after a mean follow-up of nine years. Rheumatologic complications, in particular the presence and course of ankylosing spondylitis, were examined during the same period.A hospital-based prospective study of 119 patients with HLA-B27-positive and 35 patients with HLA ...
A, Linssen, C, Meenken
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Role of HLA-B27 in Spondyloarthropathies

1996
HLA-B27 associated spondyloarthropathies are a group of inflammatory diseases primarily affecting the spine and peripheral joints. Ankylosing spondylitis (AS) is a prototypic disorder of spondyloarthropathies. Approximately 0.1 % of the Caucasian population suffers from AS in North America. Some 90% of patients with this disorder carry the HLA-B27 gene,
S D, Khare, H S, Luthra, C S, David
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Epidemiology of HLA-B27 and Arthritis

Clinical Rheumatology, 1996
HLA-B27 is present throughout Eurasia but is virtually absent among the genetically unmixed native populations of South America, Australia, and among equatorial and southern African Bantus and Sans (Bushmen). It has a very high prevalence among the native peoples of the circumpolar arctic and subarctic regions of Eurasia and North America, and in some ...
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HLA-B27 and the pathogenesis of spondyloarthropathies

Immunology Letters, 2007
The association of HLA-B27 with ankylosing spondylitis, a chronic inflammatory disease of the axial skeleton, and other spondyloarthropathies, is among the strongest of an MHC antigen and any disease. Yet, the basis for this association remains unknown.
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Genetical Factors—other than HLA-B27—in “HLA-B27-associated diseases”

Scandinavian Journal of Rheumatology, 1990
All studies among acute anterior uveitis (AAU) and ankylosing spondylitis (AS) agree on the importance of and high association with HLA-B27. However, the majority (greater than 95%) of the HLA-B27+ population will never develop such disease. There are two--generally accepted--important factors increasing the relative risk for developing AAU or AS ...
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