Results 181 to 190 of about 141,660 (219)

THE ROLE OF HLA-B27 IN ARTHRITIS

Rheumatology, 1988
We postulate (Table I) that ReA is an antigen or immune complex induced condition caused by chronic intracellular bacterial infection at a distant site. The main predisposing factor is a failure to resist this infection. If the bacteria happen to carry MF, the inflammation is exacerbated in B27 positive patients.
J R, Archer, V R, Winrow, I L, McLean
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HLA-B27 as a receptor for cytomegalovirus

Current Eye Research, 1992
Acute anterior uveitis (AAU) is strongly associated with the genetic marker and cell membrane protein HLA-B27. Although also other genetic factors must play a pathogenetic role, the HLA-class I molecule B27 is up to now the only hold. The normal task of HLA class I molecules is to present endogenous, mostly viral, peptides to receptors on cytotoxic T ...
M F, Beersma, M J, Bijlmakers, J L, Geelen, T E, Feltkamp   +3 more
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The pathogenetic role of HLA-B27

Immunology Today, 1996
In order to develop a possible animal model to study H L A linked diseases of man, we established HLA-B27 transgenic mice (TGM). As aberrant and overexpression of M H C molecules can be toxic for cells, we aimed at obtaining a physiological expression of the human antigen and used a genomic 25kb Sal I fragment for embryo injection, coding for the H L A
T E, Feltkamp, M A, Khan, J A, Lopez de Castro   +2 more
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HLA-B27 Associated Arthropathies

Radiology, 1978
The association between histo-compatibility antigens and disease is reviewed, in particular that between HLA-B27 and spondylitic disorders, i.e., ankylosing spondylitis, Reiter's arthritis, psoriatic arthritis, and ankylosing hyperostosis. We determined whether the presence of HLA-B27 predicted specific radiographic findings and, conversely, whether ...
T M, Schumacher, H K, Genant, M J, Kellet, J C, Mall, K H, Fye   +4 more
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The Role of HLA-B27 in Spondyloarthritis

The Journal of Rheumatology, 2010
This article summarizes the proceedings of a one-day international workshop held in July 2009 on the role of HLA-B27 in the pathogenesis of ankylosing spondylitis (AS) and related disorders. HLA-B27 is found in about 90% of patients with AS, with an odds ratio of about 100, but the mechanism underlying this association is not known. There are currently
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HLA-B27 and the pathogenesis of spondyloarthropathies

Immunology Letters, 2007
The association of HLA-B27 with ankylosing spondylitis, a chronic inflammatory disease of the axial skeleton, and other spondyloarthropathies, is among the strongest of an MHC antigen and any disease. Yet, the basis for this association remains unknown.
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Monoclonal Antibodies to HLA-B27

Rheumatology, 1983
Because HLA-B27 is such an important genetic marker for susceptibility to spondyloarthropathies and other related diseases, study of this alloantigen was undertaken using murine monoclonal antibodies. The first monoclonal anti-B27 antibody, B27M1, is an IgG2a lymphocytotoxic antibody that reacts with all B27 antigens and cross-reacts to a lesser degree
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Outcomes of HLA-B27-Positive and HLA-B27-Negative Acute Anterior Uveitis

American Journal of Ophthalmology, 1995
Outcomes of HLA-B27-positive and HLA-B27-negative acute anterior uveitis were assessed after a mean follow-up of nine years. Rheumatologic complications, in particular the presence and course of ankylosing spondylitis, were examined during the same period.A hospital-based prospective study of 119 patients with HLA-B27-positive and 35 patients with HLA ...
A, Linssen, C, Meenken
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Epidemiology of HLA-B27 and Arthritis

Clinical Rheumatology, 1996
HLA-B27 is present throughout Eurasia but is virtually absent among the genetically unmixed native populations of South America, Australia, and among equatorial and southern African Bantus and Sans (Bushmen). It has a very high prevalence among the native peoples of the circumpolar arctic and subarctic regions of Eurasia and North America, and in some ...
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Role of HLA-B27 in Spondyloarthropathies

1996
HLA-B27 associated spondyloarthropathies are a group of inflammatory diseases primarily affecting the spine and peripheral joints. Ankylosing spondylitis (AS) is a prototypic disorder of spondyloarthropathies. Approximately 0.1 % of the Caucasian population suffers from AS in North America. Some 90% of patients with this disorder carry the HLA-B27 gene,
S D, Khare, H S, Luthra, C S, David
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