Results 181 to 190 of about 116,043 (221)
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HLA-B27: To Type or Not to Type?
Annals of Internal Medicine, 1980The association between the histocompatibility antigen HLA-B27 and the seronegative spondylarthritides such as ankylosing spondylitis and Reiter's syndrome is dramatic. A question that arises in practice is, when should a clinician request HLA-B27 typing in the assessment of a patient with a rheumatologic complaint?
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The pathogenetic role of HLA-B27
Immunology Today, 1996In order to develop a possible animal model to study H L A linked diseases of man, we established HLA-B27 transgenic mice (TGM). As aberrant and overexpression of M H C molecules can be toxic for cells, we aimed at obtaining a physiological expression of the human antigen and used a genomic 25kb Sal I fragment for embryo injection, coding for the H L A
T E, Feltkamp +2 more
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Ophthalmology Clinics of North America, 2002
HLA-B27--associated acute anterior uveitis, a relatively common form of uveal inflammation, has a sufficiently characteristic presentation that the diagnosis is often suggested by clinical assessment, although testing for HLA-B27 status provides strong support for the diagnosis. This condition usually responds readily to topical corticosteroid therapy,
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HLA-B27--associated acute anterior uveitis, a relatively common form of uveal inflammation, has a sufficiently characteristic presentation that the diagnosis is often suggested by clinical assessment, although testing for HLA-B27 status provides strong support for the diagnosis. This condition usually responds readily to topical corticosteroid therapy,
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HLA-B27 Associated Arthropathies
Radiology, 1978The association between histo-compatibility antigens and disease is reviewed, in particular that between HLA-B27 and spondylitic disorders, i.e., ankylosing spondylitis, Reiter's arthritis, psoriatic arthritis, and ankylosing hyperostosis. We determined whether the presence of HLA-B27 predicted specific radiographic findings and, conversely, whether ...
T M, Schumacher +4 more
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HLA-B27 Is Necessary But Not Sufficient
Scandinavian Journal of Rheumatology, 1990It is discussed why some, but not all HLA-B27-positive persons get disease when triggered by certain infections. The conclusions are that a possible modifying gene may be found on the other HLA haplotype or outside the HLA complex. Given an epidemic infection afflicting a family, it is the possible differences of other environmental factors which may ...
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THE ROLE OF HLA-B27 IN ARTHRITIS
Rheumatology, 1988We postulate (Table I) that ReA is an antigen or immune complex induced condition caused by chronic intracellular bacterial infection at a distant site. The main predisposing factor is a failure to resist this infection. If the bacteria happen to carry MF, the inflammation is exacerbated in B27 positive patients.
J R, Archer, V R, Winrow, I L, McLean
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HLA-B27 and pathogenesis of spondyloarthropathies
Current Opinion in Rheumatology, 2002Although the influence of HLA-B27 on the development of spondyloarthropathies is undisputed, its role in pathogenesis remains unclear. New ideas have focused on abnormal characteristics of HLA-B27 resulting from aberrant folding, disulfide bond formation, or both, rather than a predilection for selecting arthritogenic peptides.
Matthew J, Turner, Robert A, Colbert
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HLA-B27 as a receptor for cytomegalovirus
Current Eye Research, 1992Acute anterior uveitis (AAU) is strongly associated with the genetic marker and cell membrane protein HLA-B27. Although also other genetic factors must play a pathogenetic role, the HLA-class I molecule B27 is up to now the only hold. The normal task of HLA class I molecules is to present endogenous, mostly viral, peptides to receptors on cytotoxic T ...
M F, Beersma +3 more
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Outcomes of HLA-B27-Positive and HLA-B27-Negative Acute Anterior Uveitis
American Journal of Ophthalmology, 1995Outcomes of HLA-B27-positive and HLA-B27-negative acute anterior uveitis were assessed after a mean follow-up of nine years. Rheumatologic complications, in particular the presence and course of ankylosing spondylitis, were examined during the same period.A hospital-based prospective study of 119 patients with HLA-B27-positive and 35 patients with HLA ...
A, Linssen, C, Meenken
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Role of HLA-B27 in Spondyloarthropathies
1996HLA-B27 associated spondyloarthropathies are a group of inflammatory diseases primarily affecting the spine and peripheral joints. Ankylosing spondylitis (AS) is a prototypic disorder of spondyloarthropathies. Approximately 0.1 % of the Caucasian population suffers from AS in North America. Some 90% of patients with this disorder carry the HLA-B27 gene,
S D, Khare, H S, Luthra, C S, David
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