Results 11 to 20 of about 12,247 (203)

Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up study

Pediatric Rheumatology Online Journal, 2023
Background The aim of this long-term follow-up study was to compare the disease characteristics of HLA-B27 positive and negative patients with juvenile idiopathic arthritis (JIA).
Suvi Oili Orvokki Peltoniemi, Mia Glerup, Pekka Lahdenne, Kari K Eklund, Kristiina Aalto   +4 more
doaj   +1 more source

Intrinsic Folding Properties of the HLA-B27 Heavy Chain Revealed by Single Chain Trimer Versions of Peptide-Loaded Class I Major Histocompatibility Complex Molecules

Frontiers in Immunology, 2022
Peptide-loaded Major Histocompatibility Complex (pMHC) class I molecules can be expressed in a single chain trimeric (SCT) format, composed of a specific peptide fused to the light chain beta-2 microglobulin (β2m) and MHC class I heavy chain (HC) by ...
Izabela Lenart, Izabela Lenart, Izabela Lenart, Linh-Huyen Truong, Linh-Huyen Truong, Dinh Dung Nguyen, Dinh Dung Nguyen, Olga Rasiukienė, Edward Tsao, Jonathan Armstrong, Pankaj Kumar, Kirsty McHugh, Kirsty McHugh, Branca I. Pereira, Branca I. Pereira, Branca I. Pereira, Balraj S. Maan, Balraj S. Maan, Malgorzata A. Garstka, Paul Bowness, Neil Blake, Simon J. Powis, Keith Gould, Darren Nesbeth, Antony N. Antoniou, Antony N. Antoniou   +25 more
doaj   +1 more source

Clinical picture of ankylosing spondylitis in HLA-B27 positive and negative patients

Современная ревматология, 2023
The link between the HLA-B27 gene and ankylosing spondylitis (AS) has been known for almost 50 years. During this time, it has been discovered that some of the clinical manifestations of the disease are uniformly associated with the disease in almost all
Sh. F. Erdes, K. V. Sakharova
doaj   +1 more source

Targeted delivery of an antigenic peptide to the endoplasmic reticulum: application for development of a peptide therapy for ankylosing spondylitis. [PDF]

PLoS ONE, 2013
The development of suitable methods to deliver peptides specifically to the endoplasmic reticulum (ER) can provide some potential therapeutic applications of such peptides.
Hui-Chun Yu, Ming-Chi Lu, Chin Li, Hsien-Lu Huang, Kuang-Yung Huang, Su-Qin Liu, Ning-Sheng Lai, Hsien-Bin Huang   +7 more
doaj   +1 more source

Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis

Di-san junyi daxue xuebao, 2020
Objective To analyze the positivity of human leukocyte surface antigen-B27 (HLA-B27) in patients with suspected ankylosing spondylitis (AS) and their relatives in Chongqing to understand the gender-specific distribution of HLA-B27 genotypes in the ...
GAO Lenyu, WU Hong, YOU Qingxia, WANG Yong   +3 more
doaj   +1 more source

Interaction between HLA-B60 and HLA-B27 as a Better Predictor of Ankylosing Spondylitis in a Taiwanese Population. [PDF]

PLoS ONE, 2015
Ankylosing spondylitis (AS) is a form of chronic inflammatory spondyloarthritis (SpA) that causes pain and stiffness in spines or joints. Human leukocyte antigen B27 (HLA-B27) and B60 (HLA-B60) have been reported as major genetic risk factors of AS.
James Cheng-Chung Wei, Henry Wong Sung-Ching, Yu-Wen Hsu, Ya-Feng Wen, Wen-Chang Wang, Ruey-Hong Wong, Hsing-Fang Lu, Floris A van Gaalen, Wei-Chiao Chang   +8 more
doaj   +1 more source

Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis

RMD Open, 2023
The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex whose name goes back to its discovery in studies of transplanted tissue compatibility.
Joachim Sieper, Juergen Braun
doaj   +1 more source

Human leukocyte Antigen-B*27 allele subtype prevalence and disease association of ankylosing spondylitis among south indian population

Indian Journal of Rheumatology, 2018
Aim: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis mainly affecting articular and extraarticular structures. AS clinical manifestations also involve sacroiliac joints and spine. Genetic factors play a key role in AS susceptibility.
Vikram Haridas, Praveenkumar Shetty, M Nirmal Kumar, K C Vasanthakumar, Kiran Haridas, Vitthal Khode, Anil Bargale   +6 more
doaj   +1 more source

Human leukocyte antigen B polymorphism and association between HLA‐B27 and endoplasmic reticulum aminopeptidase 1 rs30187 SNP in patients with ankylosing spondylitis in Bangladesh

Rheumatology & Autoimmunity, 2022
Objectives To determine the association of Human leukocyte antigen B (HLA‑B) alleles with ankylosing spondylitis and the allelic association of HLA‐B27 with endoplasmic reticulum aminopeptidase 1 (ERAP1) single‐nucleotide polymorphism (SNP) rs30187 in ...
Md Kamrul H. Sajib, Shamim Ahmed, Syed A. Haq, Minhaj R. Choudhury, Mohammed Uddin, Furkan Uddin, Muhammad S. A. Khan, Mohammad M. Zaman   +7 more
doaj   +1 more source

Autoinflammation and HLA-B27: Beyond Antigen Presentation [PDF]

Ocular Immunology and Inflammation, 2016
HLA-B27 associated disorders comprise a group of inflammatory conditions which have in common an association with the HLA class I molecule, HLA-B27. Given this association, these diseases are classically considered disorders of adaptive immunity. However, mounting data are challenging this assumption and confirming that innate immunity plays a more ...
openaire   +2 more sources