Results 51 to 60 of about 12,247 (203)

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk

Glia, Volume 74, Issue 1, January 2026.
C9orf72 microglia display heightened glycolysis and oxidative stress, driving astrocytic reprogramming that impacts motor neurons. iPSC tricultures uncover key glial–neuronal interactions in C9orf72 pathology. ABSTRACT The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
Marika Mearelli, Insa Hirschberg, Christin Weissleder, Carmela Giachino, María José Pérez, Malvina Dubroux, Francesca Provenzano, Mafalda Rizzuti, Linda Ottoboni, Udit Sheth, Tania F. Gendron, Stefania Corti, Michela Deleidi   +12 more
wiley   +1 more source

Generation of induced pluripotent stem cells from an HLA-B27 positive ankylosing spondylitis patient with syndesmophyte formation

Stem Cell Research
Human leukocyte antigen (HLA)-B27 is the genetic marker for ankylosing spondylitis (AS). Here, we generated induced pluripotent stem cells (iPSCs) from peripheral blood mononuclear cells of a male AS patient carrying HLA-B27 with syndesmophyte formation ...
Wan-Hao Tsai, Yen-Chun Lin, Shih-Hsun Lan, Yu-Heng Lin, Chun-Hsiung Chen, Song-Chou Hsieh, Chin-Hsiu Liu   +6 more
doaj   +1 more source

Laeverin is Cell‐Surface Target for Liquid‐Phase Metastasizing Cancer Cells

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This study revealed that epithelial cancer cells in the floating phase induce the expression of laeverin (LVRN) that is a trophoblast‐specific and cell‐surface immunoregulatory factor and showed that anti‐LVRN ADC is a promising agent that can attack cancer cells in the metastatic liquid phase and block further distant metastasis.
Haruki Kasama, Yuya Sakai, Kyosuke Kagami, Takashi Iizuka, Tatsuhito Kanda, Takuma Suzuki, Kayo Kayahashi, Masanori Ono, Tomoko Fujiwara, Shintaro Yagi, Noriyuki Inaki, Isao Matsumoto, Rena Yamazaki, Kaoru Abiko, Noriomi Matsumura, Akira Hattori, Takiko Daikoku, Hiroshi Fujiwara   +17 more
wiley   +1 more source

FOXP3+ T Cells—An Emerging Evidence in Periodontitis Therapeutics

Clinical and Experimental Dental Research, Volume 11, Issue 6, December 2025.
ABSTRACT Objective To review interaction of FOXP3+ regulatory T cells with Th17 cells in determining the progression of periodontitis. Material and Methodology Literature review pertaining to FOXP3+ regulatory T cells, Th17 cells, and periodontitis was analyzed. Descriptive summary is presented.
Revan Birke Koca Ünsal, Akira Hasuike, Tamer Badawy, Farah Asa'ad, Bruno Špiljak, Monal Yuwanati, Jelena Roganović, Yinli Liu, Carel Brigi, Danilo Milanes Zambrano, Akhilanand Chaurasia   +10 more
wiley   +1 more source

Determination of HLA-B27 Subtypes in Iranian Patients with Ankylosing Spondylitis

Iranian Journal of Allergy, Asthma and Immunology, 2008
The human leukocyte antigen-B27 is one of the class I molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (AS).
Mohamad Hossein Nicknam, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mazdak Ganjalikhani Hakemi, Farideh Khosravi, Ahmad Reza Jamshidi, Aref Amirkhani, Bita Ansaripour, Zahra Pourpak, Mostafa Moin, Behrooz Nikbin   +10 more
doaj  

Musculoskeletal Diseases: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 12, December 2025.
Musculoskeletal diseases comprise a broad spectrum of inflammatory, degenerative, and neoplastic disorders. Increasing evidence highlights the central role of immune regulation in their pathogenesis, with complex interactions among immune, bone, muscle, and stromal cells.
Xiao Ma, Eloy Yinwang, Xupeng Chai, Fangqian Wang, Zehao Chen, Shengdong Wang, Hao Zhou, Yucheng Xue, Jiangchu Lei, Fanglu Chen, Hengyuan Li, Shixin Chen, Shenzhi Zhao, Kelei Wang, Liang Chen, Junjie Gao, Zhaoming Ye, Nong Lin   +17 more
wiley   +1 more source

Comprehensive single‐cell profiling of monocytes in HLA‐B27‐positive ankylosing spondylitis with acute anterior uveitis

MedComm
Acute anterior uveitis (AAU) is a common extra‐articular manifestation of ankylosing spondylitis (AS), particularly in patients positive for the human leucocyte antigen (HLA)‐B27 genetic marker.
Huan Li, Xueming Ju, Lixin Zhang, Jing Zhu, Jing Zhang, Jialing Xiao, Ting Wang, Weijia Wu, Liang Wang, Chengzi Gan, Xiangmei Li, Yutong Wei, Siyu Zhu, Yu Zhou, Bolin Deng, Ning Xiao, Bo Gong   +16 more
doaj   +1 more source

A 66‐year‐old man with acute retinal necrosis

Brain Pathology, EarlyView.
Shino Magaki, Fausto J. Rodriguez, Matthew Koo, Colin A. McCannel   +3 more
wiley   +1 more source

Expert consensus on early diagnosis and treatment of psoriatic arthritis (2025 edition)

Rheumatology &Autoimmunity, Volume 5, Issue 4, Page 241-257, December 2025.
Psoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disease associated with psoriasis. PsA is characterized by diverse clinical manifestations and often follows a protracted, relapsing course, potentially leading to joint deformity and disability.
Ranran Yao, Lin Cai, Liling Xu, Yuhui Li, Yuan Jia, Yin Su, Chinese Expert Consensus Research Group on Early Recognition, Diagnosis and Treatment of Psoriatic Arthritis   +7 more
wiley   +1 more source

Human Leukocyte Antigen-B27 and Disease Susceptibility in Vojvodina, Serbia

Balkan Journal of Medical Genetics, 2012
There are numerous studies showing the role of human leukocyte antigens (HLAs) related with susceptibility or resistance to certain diseases.
Vojvodić S., Ademović-Sazdanić D., Busarčević I.   +2 more
doaj   +1 more source