Results 181 to 190 of about 375,043 (313)

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors. [PDF]

Sci Adv
Hwang D, Erdman MC, Adhikari S, Pantula R, Epstein K, Li P, Costabile F, Rotsides P, Wang CS, Sun SM, Fazelinia H, Spruce LA, Fugmann T, Rrustemi T, Soh WT, Farrel A, Want MY, Facciabene A, Mir M, Maris JM, Sgourakis NG.   +20 more
europepmc   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

HLA-A*02:1227 and HLA-A*36:16N, Two Novel HLA-A Alleles Identified in Brazilian Bone Marrow Donors. [PDF]

HLA
Dos Santos Júnior ACS, de Oliveira CKF, Fabreti-Oliveira RA.   +2 more
europepmc   +1 more source

Analysis of the Recovery of Immune Status in the Patients With Paroxysmal Nocturnal Hemoglobinuria After Treatment With C5 Complement Inhibitor

Journal of Clinical Laboratory Analysis, EarlyView.
We retrospectively evaluated the impact of C5 complement inhibition on immune cell profiles and recovery in 27 PNH patients; both CD4+ and CD8+ T cells exhibited partial recovery, while B cell counts increased but remained below normal levels. In contrast, Treg cells were significantly reduced in PNH patients and showed no notable change post‐treatment.
Hui Liu, Mengting Che, Liyan Li, Honglei Wang, Chaomeng Wang, Junshu Wu, Yingying Chen, Zhaoyun Liu, Lijuan Li, Rong Fu   +9 more
wiley   +1 more source

Evaluating the effect of immunization with DNA encoding Phlebotomus sergenti apyrase protein (PsSP42) against Leishmania tropica infection in BALB/c mouse model. [PDF]

Parasit Vectors
Hosseinpour Jahednia S, Rezvan H, Sarvnaz H, Habibzadeh S, Nourian A, Taheri T, Seyed N, Gholami E, Rafati S.   +8 more
europepmc   +1 more source

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source

Human CD3 complex is required for the generation of T-cell receptor-like chimeric antigen receptor targeting WT1 in natural killer cells. [PDF]

Cancer Immunol Immunother
Luanpitpong S, Poohadsuan J, Samart P, Kang X, Pratumkaew P, Janan M, Issaragrisil S.   +6 more
europepmc   +1 more source

Associations between residential greenness, land cover and risk of celiac disease in genetically at‐risk children: Celiac Prediction in Skåne study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Our aim was to study the association between residential land cover and greenness during childhood and risk of developing celiac disease (CeD). Methods The Celiac Prediction in Skåne study prospectively followed 5969 human leukocyte antigen (HLA)‐genotyped children born 2001–2004 who were screened for CeD at ages 3, 9, and 15 years ...
Michaela Boström, Marja I. Roslund, Lauri Häme, Juulia Manninen, Matthieu Molinier, Aki Sinkkonen, Daniel Agardh   +6 more
wiley   +1 more source

MHC1-TIP enables single-tube multimodal immunopeptidome profiling and uncovers intratumoral heterogeneity in antigen presentation. [PDF]

Commun Biol
Bathini M, Bocaniciu D, Johnson FD, de Jong RCP, Yu F, Aloi VD, Kuiken MC, Mors JR, Giebel L, Champagne J, Bleijerveld O, Agami R, Dijkstra KK, Thommen DS, Nesvizhskii AI, Lindeboom RGH.   +15 more
europepmc   +1 more source