Results 21 to 30 of about 1,839,216 (336)

High percentages of peripheral blood T-cell activation in childhood Hodgkin's lymphoma are associated with inferior outcome

Frontiers in Medicine, 2022
The aims of this study were to investigate the activation of T lymphocytes in peripheral blood from children with Hodgkin's lymphoma (HL) and explore their roles for prognosis in HL.
Fengqing Cai, Hui Gao, Zhongsheng Yu, Kun Zhu, Weizhong Gu, Xiaoping Guo, Xiaojun Xu, Hongqiang Shen, Qiang Shu, Qiang Shu   +9 more
doaj   +1 more source

Effect of JAK Inhibition on the Induction of Proinflammatory HLA–DR+CD90+ Rheumatoid Arthritis Synovial Fibroblasts by Interferon‐γ

Arthritis & Rheumatology, 2021
Findings from recent transcriptome analyses of the synovium of patients with rheumatoid arthritis (RA) have revealed that 15‐fold expanded HLA–DR+CD90+ synovial fibroblasts potentially act as key mediators of inflammation.
Shuyang Zhao, Ricardo Grieshaber-Bouyer, Deepak A. Rao, P. Kolb, Haizhang Chen, Ivana Andreeva, T. Tretter, H. Lorenz, C. Watzl, G. Wabnitz, L. Tykocinski, W. Merkt   +11 more
semanticscholar   +1 more source

A Multi-Omics Analysis of Metastatic Melanoma Identifies a Germinal Center-Like Tumor Microenvironment in HLA-DR-Positive Tumor Areas

Frontiers in Oncology, 2021
The emergence of immune checkpoint inhibitors has dramatically changed the therapeutic landscape for patients with advanced melanoma. However, relatively low response rates and a high incidence of severe immune-related adverse events have prompted the ...
Laura Gadeyne, Yannick Van Herck, Giorgia Milli, Zeynep Kalender Atak, Maddalena Maria Bolognesi, Jasper Wouters, Lukas Marcelis, Angeliki Minia, Vaia Pliaka, Jan Roznac, Jan Roznac, Leonidas G. Alexopoulos, Leonidas G. Alexopoulos, Giorgio Cattoretti, Oliver Bechter, Joost Van Den Oord, Frederik De Smet, Asier Antoranz, Francesca Maria Bosisio   +18 more
doaj   +1 more source

NetMHCIIpan-3.0, a common pan-specific MHC class II prediction method including all three human MHC class II isotypes, HLA-DR, HLA-DP and HLA-DQ

Immunogenetics, 2013
Ole Lund, Søren Buus, Morten Nielsen
exaly   +2 more sources

Antigen presenting subset of СD66b⁺CD16⁺CD33⁺HLA-DR⁺ neutrophilic granulocytes in acute osteomyelitis in children: Immunomodulating effects of immunotropic hexapeptide in an in vitro experimental system

Медицинская иммунология, 2023
Inclusion of neutrophilic granulocytes (NG) in inflammation depends on the expression of receptors providing the functions of NG. Acute osteomyelitis (AOM) occupies a central place among purulentinflammatory diseases in children.
I. V. Nesterova, G. A. Chudilova, Yu. V. Teterin, E. A. Chicherev, V. N. Chapurina, M. N. Mitropanova   +5 more
doaj   +1 more source

Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma. [PDF]

, 2020
ObjectiveAutoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality.
Boin, Francesco, Cole, Robert N, Darrah, Erika, Fava, Andrea, Guhr, Tara, McMahan, Zsuzsanna H, O'Meally, Robert N, Shah, Ami A, Tiniakou, Eleni, Wigley, Fredrick M   +9 more
core   +1 more source

HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells

Stem Cells International, 2021
Although human induced pluripotent stem cells (iPSCs) can serve as a universal cell source for regenerative medicine, the use of iPSCs in clinical applications is limited by prohibitive costs and prolonged generation time.
Yoo-Wook Kwon, Hyo-Suk Ahn, Jin-Woo Lee, Han-Mo Yang, Hyun-Jai Cho, Seok Joong Kim, Shin-Hyae Lee, Heung-Mo Yang, Hyun-Duk Jang, Sung Joo Kim, Hyo-Soo Kim   +10 more
doaj   +1 more source

Imputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosus. [PDF]

PLoS ONE, 2016
The genetic association of HLA-DRB1 with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5) has not been thoroughly studied, despite their ...
Kwangwoo Kim, So-Young Bang, Dae Hyun Yoo, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Young Mo Kang, Chang-Hee Suh, Seung-Cheol Shim, Shin-Seok Lee, Jisoo Lee, Won Tae Chung, Seong-Kyu Kim, Jung-Yoon Choe, Swapan K Nath, Hye-Soon Lee, Sang-Cheol Bae   +18 more
doaj   +1 more source

DR-bearing T lymphocytes in thoracic duct lymph [PDF]

, 1981
T cells having DR antigens were shown to be present in high numbers in the thoracic duct lymph of patients undergoing long-term drainage. As drainage progresses the proportion of T DR cells in the lymph increases to levels as high as 70% at 6 weeks ...
Abo, Albrechtson, Billing, Boyle, Colombani, Evans, Foon, Franksson, Fu, Greaves, H. Takahashi, J.C. Cicciarelli, Johnson, Kaplan, Machleder, Matell, Medawar, P.I. Terasaki, R. Billing, Starzl, Starzl, Suciu-Foca, T. Starzl, T. Yamaguchi, Terasaki, Y. Iwaki   +25 more
core   +1 more source

High levels of genetically-intact HIV in HLA-DR+ memory T-cells indicates their value for reservoir studies.

AIDS (London), 2020
OBJECTIVE The contribution of HLA-DR+ memory CD4+ T-cells to the HIV reservoir during prolonged antiretroviral therapy is unclear as these cells are commonly excluded when assessing for replication-competent HIV.
B. Horsburgh, Eunok Lee, B. Hiener, John-Sebastian Eden, T. Schlub, S. von Stockenstrom, L. Odevall, J. Milush, T. Liegler, E. Sinclair, R. Hoh, E. Boritz, D. Douek, R. Fromentin, N. Chomont, S. Deeks, F. Hecht, S. Palmer   +17 more
semanticscholar   +1 more source