Results 251 to 260 of about 114,761 (352)
We evaluated sequential tumor biopsies during therapy to test the hypotheses that BRAF/MEKi would increase TIL and lead to an expansion of functional intratumoral tumor‐reactive CD8 T‐cells and TIL clonality in the tumor microenvironment. Data from this study provides provocative evidence that, while BRAF+/−MEK inhibitor therapy produces an increase in
Suthee Rapisuwon +12 more
wiley +1 more source
Toward next-generation therapeutic HPV vaccines: A review on expanding the antigen repertoire and an integrated bioinformatics selection framework. [PDF]
Zhang D +5 more
europepmc +1 more source
ABSTRACT The crosstalk between immune cells in skin lesions of numerous immune‐mediated diseases such as atopic dermatitis, psoriasis and other T cell mediated is fundamental for understanding the pathogenesis and treating these diseases. The mechanisms by which most activated immune cells such as T cells, mast cells, and neutrophils are shifted from ...
Elias Toubi +2 more
wiley +1 more source
Differential Alloreactivity: Lessons Learned From a Singular HLA Locus. [PDF]
Arrieta-Bolaños E.
europepmc +1 more source
Generation of effector cells from T cell subsets [PDF]
Koszinowski, Ulrich H., Simon, M. M.
core
UGT1A1 and Sacituzumab Govitecan Toxicity: A Systematic Review and Meta‐Analysis
Sacituzumab govitecan (SG), a humanized antibody‐drug conjugate, enables intra‐tumor delivery of SN‐38, the active metabolite of irinotecan, with the aim of increasing efficacy. SN‐38 is predominantly inactivated by the polymorphically expressed uridine diphosphate glucuronosyltransferase 1A1 (UGT1AA) where reduced activity can lead to toxicity.
Cinzia Dello Russo +4 more
wiley +1 more source

