Results 251 to 260 of about 114,761 (352)

Effects of Vemurafenib ± Cobimetinib on Intratumoral and Host Immunity in Patients With BRAFV600 Mutant Melanoma: Implications for Combination With Immunotherapy

open access: yesCancer Medicine, Volume 15, Issue 1, January 2026.
We evaluated sequential tumor biopsies during therapy to test the hypotheses that BRAF/MEKi would increase TIL and lead to an expansion of functional intratumoral tumor‐reactive CD8 T‐cells and TIL clonality in the tumor microenvironment. Data from this study provides provocative evidence that, while BRAF+/−MEK inhibitor therapy produces an increase in
Suthee Rapisuwon   +12 more
wiley   +1 more source

T Cell/Mast Cell Crosstalk in the Skin of Patients Suffering From Immune‐Mediated Diseases, Focusing on Chronic Spontaneous Urticaria

open access: yesClinical and Translational Allergy, Volume 16, Issue 1, January 2026.
ABSTRACT The crosstalk between immune cells in skin lesions of numerous immune‐mediated diseases such as atopic dermatitis, psoriasis and other T cell mediated is fundamental for understanding the pathogenesis and treating these diseases. The mechanisms by which most activated immune cells such as T cells, mast cells, and neutrophils are shifted from ...
Elias Toubi   +2 more
wiley   +1 more source

Generation of effector cells from T cell subsets [PDF]

open access: yes, 1979
Koszinowski, Ulrich H., Simon, M. M.
core  

Analysis of human T-cell epitopes in the 19,000 MW antigen of Mycobacterium tuberculosis: influence of HLA-DR.

open access: green, 1991
A. Faith   +8 more
openalex   +1 more source

Circulating HLA-DR+ natural killer cells have potent lytic ability and weak antigen-presenting cell function

open access: bronze, 2008
Bryan M. Burt   +5 more
openalex   +2 more sources

UGT1A1 and Sacituzumab Govitecan Toxicity: A Systematic Review and Meta‐Analysis

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 63-73, January 2026.
Sacituzumab govitecan (SG), a humanized antibody‐drug conjugate, enables intra‐tumor delivery of SN‐38, the active metabolite of irinotecan, with the aim of increasing efficacy. SN‐38 is predominantly inactivated by the polymorphically expressed uridine diphosphate glucuronosyltransferase 1A1 (UGT1AA) where reduced activity can lead to toxicity.
Cinzia Dello Russo   +4 more
wiley   +1 more source

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