Results 21 to 30 of about 150,948 (189)

Autoimmune and non-autoimmune thyroid diseases have different patterns of cellular HLA class II expression

open access: yesSão Paulo Medical Journal
CONTEXT: Surface HLA-DR antigen is usually only expressed by antigen-presenting cells (APC). In autoimmune thyroid disease, follicle cells function as APC, thus expressing HLA-DR. However, non-autoimmune thyroid diseases may also express surface class II
Denise Engelbrecht Zantut-Wittmann   +4 more
doaj   +1 more source

Association of Alport's syndrome with HLA-DR2 antigen in a group of unrelated patients

open access: yesBrazilian Journal of Medical and Biological Research, 1998
A few family studies have evaluated HLA antigens in Alport's syndrome; however, there are no large population studies. In the present report, we studied 40 unrelated white patients with Alport's syndrome seen at the Unit of Renal Transplantation, Faculty
E.A. Donadi   +4 more
doaj   +1 more source

Immunopathology of american cutaneous leishmaniasis. Modulation of MHC class II gene products by Keratinocytes before and after glucantime therapy

open access: yesMemorias do Instituto Oswaldo Cruz, 1990
Epidermal changes from 32 cutaneous and 3 mucosal American leishmaniasis (ACL) active lesions were studied for HLA-DR, -DP expression, Lanerhans cells and lymphocyte infiltration.
Claude Pirmez   +3 more
doaj   +1 more source

Monoclonal antibodies against HLA-DR antigens replace T helper cells in activation of B lymphocytes.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 1983
In the presence but not in the absence of pokeweed mitogen (PWM), monoclonal antibodies against HLA-DR antigens 147 and 164 helped highly purified B lymphocytes to proliferate and mature to Ig-secreting cells.
R. Palacios, O. Martínez-Maza, K. Guy
semanticscholar   +1 more source

Determination of HLA-A, -B and -DRB1 polymorphism in brain dead organ donors representative of the Colombian general population, 2007-2014

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2017
Introduction: Genes encoding for human leukocyte antigens (HLA) are highly polymorphic and of great importance in organ transplantation procedures, as determining allelic frequencies in defined populations is taken into account among the scientific ...
Yazmin Rocío Arias   +4 more
doaj   +1 more source

Quantitative predictions of peptide binding to any HLA-DR molecule of known sequence: NetMHCIIpan.

open access: yesPLoS Computational Biology, 2008
CD4 positive T helper cells control many aspects of specific immunity. These cells are specific for peptides derived from protein antigens and presented by molecules of the extremely polymorphic major histocompatibility complex (MHC) class II system. The
Morten Nielsen   +7 more
doaj   +1 more source

ASSOCIATION OF HLA AND CYTOKINES OF BLOOD WITH ANTIINFLAMMATORY EFFECTS IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS

open access: yesУкраїнський Журнал Нефрології та Діалізу, 2017
Cytokines and HLA take important part in immunogenesis of many diseases, therefore the analysis of these indices and this associations in dependence of glomerulonephritis (GN) can define their value as the additional prognostic markers.
M. Kolesnyk   +5 more
doaj   +1 more source

Immunoinformatic Analysis of Human Thyroglobulin

open access: yesCybernetics and Information Technologies, 2020
The AutoImmune ThyroiDitis (AITD), known as Hashimoto’s disease, is a chronic autoimmune thyroid disease progressively developed to hypothyroidism. The AITD is characterized by the formation of autoantibodies targeting two specific thyroid antigens ...
Doytchinova Irini   +2 more
doaj   +1 more source

Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens.

open access: yesJournal of Immunology, 1993
CD38, a molecule with multilineage distribution but unknown function, and the MHC class II molecule HLA-DR (DR) have markedly elevated levels of expression on CD8+ cells of HIV-infected people.
Hong-Nerng Ho   +9 more
semanticscholar   +1 more source

Evidence for Highly Variable, Region-Specific Patterns of T-Cell Epitope Mutations Accumulating in Mycobacterium tuberculosis Strains

open access: yesFrontiers in Immunology, 2019
Vaccines that confer protection through induction of adaptive T-cell immunity rely on understanding T-cell epitope (TCE) evolution induced by immune escape.
Arunachalam Ramaiah   +16 more
doaj   +1 more source

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