Results 31 to 40 of about 114,761 (352)

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Evaluation of 28 Human Embryonic Stem Cell Lines for Use as Unrelated Donors in Stem Cell Therapy: Implications of HLA and ABO Genotypes

Cell Transplantation, 2010
For human embryonic stem cells (hESCs) to be used clinically, it is imperative that immune responses evoked by hESCs and their derivates after transplantation should be prevented.
Jeoung Eun Lee, Myung Seo Kang, Myoung Hee Park, Sung Han Shim, Tae Ki Yoon, Hyung Min Chung, Dong Ryul Lee Ph.D.   +6 more
doaj   +1 more source

EVALUATION OF HUMAN LEUKOCYTE ANTIGEN CLASS I AND II ANTIGENS IN HELICOBACTER PYLORI-POSITIVE PEDIATRIC PATIENTS WITH ACTIVE GASTRITIS AND DUODENAL ULCER

Arquivos de Gastroenterologia, 2017
BACKGROUND: As being the first bacteria determined to be carcinogenic, Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more than half of the world population.
Sevim GÖNEN, Sinan SARI, Yaşar KANDUR, Buket DALGIÇ, Oğuz SÖYLEMEZOĞLU   +4 more
doaj   +1 more source

Autoimmune and non-autoimmune thyroid diseases have different patterns of cellular HLA class II expression

São Paulo Medical Journal
CONTEXT: Surface HLA-DR antigen is usually only expressed by antigen-presenting cells (APC). In autoimmune thyroid disease, follicle cells function as APC, thus expressing HLA-DR. However, non-autoimmune thyroid diseases may also express surface class II
Denise Engelbrecht Zantut-Wittmann, Luís Henrique Barbosa Boechat, Glauce Aparecida Pinto, Miriam Aparecida da Silva Trevisan, José Vassallo   +4 more
doaj   +1 more source

Idiopathic focal segmental glomerulosclerosis and HLA antigens

Brazilian Journal of Medical and Biological Research, 1998
The objective of the present study was to investigate a possible association between HLA class II antigens and idiopathic focal segmental glomerulosclerosis (FSGS).
M. Gerbase-DeLima, A. Pereira-Santos, R. Sesso, J. Temin, E.S. Aragão, H. Ajzen   +5 more
doaj   +1 more source

HLA-DR antigens and diabetic nephropathy [PDF]

Diabetologia, 1983
En reponse a une etude affirmant une association entre le phenotype HLA DR3/DR4 et les nephropathies diabetiques chez 26 sujets insulinodependants, l'auteur, a l'aide d'une nouvelle etude chez 61 diabetiques insulinodependants avec nephropathie, conclut que cette association entre HLA et nephropathie n'est pas ...
B. Saner, E. Bonney, J. Barbosa
openaire   +1 more source

Functional characterization of infiltrating T lymphocytes in human hepatic allografts [PDF]

, 1986
We have employed recently developed techniques in T-cell culturing to study the nature and function of infiltrating hepatic allograft T cells. Using the rationale that intragraft T cells are activated during cell mediated damage to the allograft, we were
Adriana Zeevi, Ascher, Bernard, Bono, Brodsky, Brodsky, Brodsky, Burdick, Burdick, Cerilli, Depper, Fiche, Goyert, HancocK, Harty, Hayry, Hoshinaga, Houssin, Iwatsuki, Iwatsuki, Iwatsuki, Jake Demetris, Jeannet, John J. Fung, Kim, Kolbeck, Lampson, Marboe, Mayer, Moreau, Palacios, Paradis, Pober, Rene J. Duquesnoy, Roberts, Shaw, Shunzaburo Iwatsuki, Snover, Spits, Starzl, Steinmuller, Stelzer, Strassman, Thomas E. Starzl, Thompson, Thorley-Lawson, Tilney, van Es, Weintraub, Zeevi, Zeevi, Zeevi, Zeevi, Zeevi   +53 more
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Association of Alport's syndrome with HLA-DR2 antigen in a group of unrelated patients

Brazilian Journal of Medical and Biological Research, 1998
A few family studies have evaluated HLA antigens in Alport's syndrome; however, there are no large population studies. In the present report, we studied 40 unrelated white patients with Alport's syndrome seen at the Unit of Renal Transplantation, Faculty
E.A. Donadi, J.C. Voltarelli, C.M. Paula-Santos, T. Kimachi, A.S. Ferraz   +4 more
doaj   +1 more source

HLA-DR antigen-positive acute promyelocytic leukemia

Experimental and Molecular Pathology, 2016
Acute promyelocytic leukemia (APL) with t(15;17)(q22;q21)/PML-RARα is a subtype of acute myeloid leukemia (AML) with distinct morphologic and immunophenotypic characteristics. It is a highly aggressive disease that requires rapid diagnosis and early intervention.
Alejandro S. Mendoza, Xin Qing, Maria Dungo, Joseph Lasky, Eduard Panosyan, Junchao Cai   +5 more
openaire   +2 more sources