Human leukocyte antigen-G (HLA-G) polymorphism and expression in breast cancer patients. [PDF]
PLoS ONE, 2014 Human leukocyte antigen-G (HLA-G) is known to be implicated in a tumor-driven immune escape mechanism in malignancies. The purpose of this study was to investigate HLA-G polymorphism and expression in breast cancer.
Seri Jeong +5 more
doaj +1 more source
Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. [PDF]
, 2019 Mesenchymal stem/stromal cells (MSCs) display potent immunomodulatory and regenerative capabilities through the secretion of bioactive factors, such as proteins, cytokines, chemokines as well as the release of extracellular vesicles (EVs).
Barthe, Sylvain +11 more
core +2 more sources
Enhanced Immunomodulation in Inflammatory Environments Favors Human Cardiac Mesenchymal Stromal-Like Cells for Allogeneic Cell Therapies [PDF]
, 2019 Rising numbers of patients with cardiovascular diseases and limited availability of donor hearts require new and improved therapy strategies. Human atrial appendage-derived cells (hAACs) are promising candidates for an allogeneic cell-based treatment. In
Diedrichs, Falk +5 more
core +1 more source
PLoS ONE, 2023 Graft rejection is a critical risk in solid-organ transplantation. To decrease such risk, an understanding of the factors involved in low immunogenicity of liver allografts could potentially make it possible to transfer this tolerogenic property to other
Bastien Le Floc'h +9 more
doaj +1 more source
Research on HLA‐G: an update† [PDF]
Tissue Antigens, 2007 AbstractHuman leukocyte antigen (HLA)‐G is a nonclassical HLA class I molecule from the major histocompatibility complex, which was initially shown to confer protection to the fetus from her mother’s immune system. The Third International Conference on HLA‐G, held in 2003, showed that beyond its role in fetal–maternal tolerance, HLA‐G exerts ...
B, Favier +5 more
openaire +2 more sources
Gelatinase and oncofetal fibronectin secretion is dependent on integrin expression on human cytotrophoblasts [PDF]
, 2017 Collagenolytic activity of cytotrophoblasts is stimulated by glycoproteins of the extracellular matrix and since this stimulation can possibly occur through integrins, we measured the gelatinolytic activity of villous and extravillous cytotrophoblasts ...
Bischof, P., Campana, A., Haenggeli, L.
core
miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS. [PDF]
, 2019 ObjectiveOnset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped-MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small ...
Aaen, Gregory +31 more
core +2 more sources
The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease [PDF]
, 2017 HLA-G is a non-classical MHC class Ib molecule predominantly expressed in cytotrophoblasts and under pathological conditions also in chronically inflamed and in malignant tissues. Recently an increased expression of HLA-G was found in ulcerative colitis (
Beynon, Vanessa +14 more
core
An expanding range of targets for kynurenine metabolites of tryptophan [PDF]
, 2013 The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail +2 more
core +1 more source
Prognostic Value of HLA-G in Malignant Liver and Pancreas Lesions [PDF]
Iranian Journal of Immunology, 2018 Background: Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule with modulatory effects on NK and T cells. Because HLA-G expression is frequently detected in different solid tumors, it may be involved in tumor immune evasion. Objective:
Parisa Khodabandeh Shahraki +4 more
doaj