Results 71 to 80 of about 11,789,754 (116)

HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels

, 2003
During pregnancy, the human extra-villous trophoblast in the contact zone between maternal and fetal tissue in the placenta does not express the classical MHC class I and II molecules. Instead, HLA-G and -C, and possibly HLA-E, are expressed.
Nielsen, Lone G, Hylenius, Sine, Hviid, Thomas Vauvert F, Rørbye, Christina   +3 more
core   +1 more source

HLA-G Expressing Immune Cells in Immune Mediated Diseases

, 2020
HLA-G is a HLA class Ib antigen that possesses immunomodulatory properties. HLA-G-expressing CD4+ and CD8+ T lymphocytes, NK cells, monocytes, and dendritic cells with immunoregulatory functions are present in small percentages of patients with ...
Negrini S., Contini P., Murdaca G., Puppo F.   +3 more
core   +1 more source

Controlling the immunological crosstalk during conception and pregnancy: HLA-G in reproduction

Frontiers in Immunology, 2014
In several years after its discovery in the placenta, the Human Leukocyte Antigen (HLA) class Ib protein, HLA-G, was not given much attention, nor was it assigned great importance. As time has unraveled, HLA-G has proven to have distinctive functions and
Line eLynge Nilsson, Snezana eDjurisic, Thomas Vauvert Hviid   +2 more
doaj   +1 more source

Contributions of vitamin D response elements and HLA promoters to multiple sclerosis risk [PDF]

, 2012
Objective: The identification of a vitamin D-responsive (VDRE) motif within the HLA-DRB1*15:01 promoter region provides an attractive explanation for the combined effects of HLA-DR inheritance and vitamin D exposure on multiple sclerosis (MS) risk.
Qiu, W., Nolan, D., Kermode, A., Tschochner, M., Mastaglia, F., Christiansen, F.T., Witt, C., Castley, A., James, I., Sayer, D., Carroll, W.   +10 more
core  

HLA-G*0105N null allele encodes functional HLA-G isoforms. [PDF]

, 2005
Expression of the nonclassical HLA class I antigen, HLA-G, is associated with immune tolerance in view of its role in maintaining the fetus in utero, allowing tumor escape, and favoring graft acceptance.
Le Discorde, Magali, Rouas-Freiss, Nathalie, Caroline Le Danff, Moreau, Philippe, Nathalie Rouas-Freiss, Carosella, Edgardo D, Le Danff, Caroline, Philippe Moreau, Edgardo D. Carosella, Magali Le Discorde   +9 more
core   +1 more source

High-throughput high-resolution class I HLA genotyping in East Africa. [PDF]

, 2010
HLA, the most genetically diverse loci in the human genome, play a crucial role in host-pathogen interaction by mediating innate and adaptive cellular immune responses. A vast number of infectious diseases affect East Africa, including HIV/AIDS, malaria,
Leonard Maboko, Eller, Michael, Jerome Kim, Rebecca N Koehler, Francine E McCutchan, Michael Eller, Christian T Bautista, Hoelscher Michael, Eller, Leigh Anne, Jeffrey R Currier, Currier Jeffrey R., Nelson L Michael, Michael, Nelson L., Kijak, Gustavo H, Maboko Leonard, Michael, Nelson L, McCutchan, Francine E., Michael Nelson L., Maboko, Leonard, Walsh, Anne M, Wabwire-Mangen Fred, Fred Wabwire-Mangen, Wabwire-Mangen, Fred, Currier, Jeffrey R, Eller Michael, McCutchan, Francine E, Eric E Sanders-Buell, Sanders-Buell, Eric E., Robb, Merlin L, Robb Merlin L., Kijak Gustavo H., Leigh Anne Eller, Kim Jerome, Robb, Merlin L., Bautista Christian T., Anne M Walsh, Hoelscher, Michael, Kijak, Gustavo H., Bautista, Christian T, Michael Hoelscher, McCutchan Francine E., Kim, Jerome, Eller Leigh Anne, Koehler, Rebecca N, Merlin L Robb, Bautista, Christian T., Koehler, Rebecca N., Koehler Rebecca N., Sanders-Buell, Eric E, Sanders-Buell Eric E., Walsh, Anne M., Currier, Jeffrey R., Gustavo H Kijak, Walsh Anne M.   +53 more
core   +2 more sources

Identification of a novel HLA-C*08 allele, HLA-C*08:01:20

, 2017
HLA-C*08:01:20 differs from C*08:01:01 by a single nucleotide substitution at position 93 of exon 2.SCI(E)EDITORIAL MATERIAL3178 ...
D. Li, Yu, Y., B. Xi, M.-R. Huo, Xi, B., Li, D., Huo, M.R., Y. Yu   +7 more
core   +1 more source

HLA-G functions as a tumor-intrinsic driver of growth and survival in renal cell carcinoma

OncoImmunology
HLA-G is a non-classical MHC class I molecule with potent immunoregulatory functions that is aberrantly expressed in multiple malignancies, yet its tumor-intrinsic role remains poorly defined.
Ashwin Ajith, Aparna Geetha Jayaprasad, Useong Chang, Arsha Sreekumar, Mia Lin, Valia Bravo-Egana, Laura L. Mulloy, Daniel David Horuzsko, Edgardo D. Carosella, Anatolij Horuzsko   +9 more
doaj   +1 more source

Characterisation of HLA-specific antibodies [PDF]

A successful kidney transplant is the best treatment for established renal failure, yet around 300 patients per annum are denied transplants because they have antibodies, most notably directed against donor HLA or ABO in their blood, which have the ...
Lowe, David Philip
core  

Mapping the Landscape of Host-Pathogen Coevolution: HLA Class I Binding and Its Relationship with Evolutionary Conservation in Human and Viral Proteins [PDF]

, 2011
The high diversity of HLA binding preferences has been driven by the sequence diversity of short segments of relevant pathogenic proteins presented by HLA molecules to the immune system.
Jojic, N., Hertz, T., Nolan, D., John, M., Gaudieri, S., Phillips, E.J., James, I., Huang, J.C., Riadi, G., Mallal, S.   +9 more
core