Results 81 to 90 of about 12,878,485 (338)

The role of HLA-G molecule and HLA-G gene polymorphisms in tumors, viral hepatitis and parasitic diseases

Frontiers in Immunology, 2015
Considering that the non-classical HLA-G molecule has well-recognized tolerogenic properties, HLA-G expression is expected to be deleterious when present in tumor cells and in cells chronically infected by viruses, whereas HLA-G expression is expected to
Fabrício César Dias, Erick C. Castelli, Cristhianna Viesti Advincula Collares, Philippe eMoreau, Eduardo Antonio Donadi   +4 more
doaj   +1 more source

HLA-G in Allergy: Does It Play an Immunoregulatory Role?

Frontiers in Immunology, 2022
Allergy is an inflammatory process determined by a cascade of immune events characterized by T-helper 2 lymphocytes polarization leading to interleukin-4 upregulation, IgE secretion, and mast cell and eosinophil activation.
Simone Negrini, Paola Contini, Giuseppe Murdaca, Francesco Puppo   +3 more
doaj   +1 more source

CD8+PD-1–ILT2+ T Cells Are an Intratumoral Cytotoxic Population Selectively Inhibited by the Immune-Checkpoint HLA-G

Cancer immunology research, 2019
Transcriptomic and flow cytometric characterization of renal carcinoma identified intratumoral CD8+ILT2+ T cells as a terminally differentiated, effector cell subset lacking PD-1 expression.
C. Dumont, A. Jacquier, J. Vérine, Floriane Noel, A. Goujon, Ching-Lien Wu, Tzu-Min Hung, F. Desgrandchamps, S. Culine, E. Carosella, N. Rouas-Freiss, J. LeMaoult   +11 more
semanticscholar   +1 more source

Predicting the most deleterious missense nsSNPs of the protein isoforms of the human HLA-G gene and in silico evaluation of their structural and functional consequences

BMC Genetics, 2020
Background The Human Leukocyte Antigen G (HLA-G) protein is an immune tolerogenic molecule with 7 isoforms. The change of expression level and some polymorphisms of the HLA-G gene are involved in various pathologies.
Elaheh Emadi, F. Akhoundi, S. Kalantar, M. Emadi-Baygi   +3 more
semanticscholar   +1 more source

Nitric oxide produces HLA-G nitration and induces metalloprotease-dependent shedding creating a tolerogenic milieu [PDF]

, 2009
Human leucocyte antigen G (HLA-G) is a tolerogenic molecule that protects the fetus from maternal immune attack, may favour tumoral immunoescape and is up-regulated in viral and inflammatory diseases.
Alegre-Martinez, E. (Estibaliz), Carosella, E.D. (Edgardo D.), Diaz-Lagares, A. (Ángel), Gonzalez-Hernandez, A. (Alvaro), LeMaoult, J. (Joël)   +4 more
core  

Non-classical immunology. Meeting Report [PDF]

, 2001
This large annual immunology meeting covered a wide range of subjects from biochemical protein characterizations to cell biology and the study of complex disease pathologies.
Allen, RL
core   +1 more source

Effectiveness and Safety of Baricitinib for Juvenile Idiopathic Arthritis–Associated Uveitis or Chronic Anterior Antinuclear Antibody–Positive Uveitis

Arthritis Care &Research, EarlyView.
Objective To evaluate the efficacy and safety of baricitinib in pediatric patients with active juvenile idiopathic arthritis–associated uveitis (JIA‐U) or chronic anterior antinuclear antibody–positive uveitis, who had an inadequate response to methotrexate (MTX) or biologic disease‐modifying antirheumatic drugs (bDMARDs).
Athimalaipet V. Ramanan, Catherine M. Guly, Gabriele Simonini, Stuart Y. Keller, Priyanka Sen, Thorsten Holzkaemper, Joana Araújo, Pierre Quartier   +7 more
wiley   +1 more source

HLA-G Dimers in the Prolongation of Kidney Allograft Survival

Journal of Immunology Research, 2014
Human leukocyte antigen-G (HLA-G) contributes to acceptance of allografts in solid organ/tissue transplantation. Most studies have determined that soluble HLA-G isoforms are systematically detected in serum/plasma of transplanted patients with ...
Maureen Ezeakile, Vera Portik-Dobos, Juan Wu, Daniel D. Horuzsko, Rajan Kapoor, Muralidharan Jagadeesan, Laura L. Mulloy, Anatolij Horuzsko   +7 more
doaj   +1 more source

Soluble HLA-G and HLA-G Bearing Extracellular Vesicles Affect ILT-2 Positive and ILT-2 Negative CD8 T Cells Complementary

Frontiers in Immunology, 2020
Tumor immune escape is associated with both, the expression of immune checkpoint molecules on peripheral immune cells and soluble forms of the human leukocyte antigen-G (HLA-G) in the blood, which are consequently discussed as clinical biomarker for ...
Esther Schwich, Gia-Gia T. Hò, J. LeMaoult, C. Bade-Döding, E. Carosella, P. Horn, V. Rebmann   +6 more
semanticscholar   +1 more source

Immune Checkpoint Inhibitor Related Myositis and Associated Triad Overlap Syndrome

Arthritis Care &Research, Accepted Article.
Objective Immune checkpoint inhibitor (ICI) myositis is a rare but highly morbid condition, particularly with the ICI myositis triad syndrome of myositis, myocarditis, and myasthenia gravis. We report the clinical characteristics of ICI myositis and all‐cause mortality in these patients.
Selene Rubino, Grant W Cannon, Brian C Sauer, Jorge Rojas, Gregory J Stoddard, Gary A Kunkel, Jessica A. Walsh, Bryant R England, Joshua F Baker, Tawnie J Braaten   +9 more
wiley   +1 more source