Results 101 to 110 of about 795,110 (304)

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Prevalence of pre-transplant anti-HLA antibodies and their impact on outcomes in lung transplant recipients

BMC Pulmonary Medicine, 2018
Background Previous studies have suggested that antibodies against human leukocyte antigen (HLA) are associated with worse outcomes in lung transplantation.
Ji Eun Park, Chi Young Kim, Moo Suk Park, Joo Han Song, Young Sam Kim, Jin Gu Lee, Hyo Chae Paik, Song Yee Kim   +7 more
doaj   +1 more source

HLA antibodies in kidney transplantation

, 2009
In renal transplantation donor-recipient HLA-matching is performed considering HLA-A, B and DR "broad" antigens. Several studies had demonstrated that sensitized patients could produce antibodies against all HLA class I and Il molecules. In 350 HLA class
Elvira Poggi, Antonina Piazza, Domenico Adorno, Giuseppina Ozzella, Manuela Catalano, Daniela Caputo   +5 more
core  

Screening for Non-HLA Antibodies – the very first results [PDF]

Cilj: Važnost i uloga antitijela usmjerenih protiv humanih leukocitnih antigena (HLA) u reakcijama odbacivanja posredovanih antitijelima nakon transplantacije solidnih organa danas je jasno dokazana.
Jukić, Lucija, Žunec, Renata, Burek Kamenarić, Marija   +2 more
core   +1 more source

Five commercially-available antibodies react differentially with allelic forms of human HLA-DR beta chain

, 2022
Allelic variants of HLA-DRB1 have been associated with a variety of autoimmune and infectious diseases. Although the precise molecular mechanisms by which HLA-DRB1 alleles predispose to a particular disease are currently unclear, it has been shown that ...
Klareskog, Lars, Padyukov, L,, Padyukov, Leonid, Dzebisashvili, A, Klareskog, L,, Ronnblom, L, Kozhukh, Genadiy, Houtman, M,, Malmstrom, V, Houtman, Miranda, Dubnovitsky, A,, Kozhukh, G, Dzebisashvili, Anna, Dubnovitsky, Anatoly, Malmstrom, Vivianne, Rönnblom, Lars, Malmstrom, Vivianne,, Houtman, Miranda,, Dubnovitsky, Anatoly,, Kozhukh, Genadiy,, Padyukov, Leonid,, Klareskog, Lars,, Dzebisashvili, Anna,, Rönnblom, Lars,   +23 more
core   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

Allogeneic Hematopoietic Stem Cell Transplant recipients in Spain: Human Leucocyte Antigen characteristics and diversity by high-resolution analysis

There are many studies on the polymorphism of the HLA system in healthy donor populations, such as registries of unrelated bone marrow donors. Investigations on the characterization of the HLA complex in hematopoietic stem cell transplant (HSCT) patients,
Solano Vercet, Carlos, Planelles Silvestre, Dolores, Piñana, José Luis, Guerreiro, Manuel   +3 more
core   +1 more source

Molecular MRI Reveals Macrophage‐Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer

Advanced Science, EarlyView.
Incomplete microwave ablation (iMWA) induced a spatially organized, macrophage‐rich immunosuppressive tumor microenvironment (TME) in orthotopic VX2 liver tumors. Molecular MRI enhanced with europium‐doped very small superparamagnetic iron oxide nanoparticles (Eu‐VSOP) noninvasively visualized this remodeling, showing preferential nanoparticle ...
Yubei He, Han Xu, Julian M. M. Rogasch, Nikolaus Berndt, Jing Guo, Eyk Schellenberger, Akvile Häckel, Luisa Heidemann, Friederike Hesse, Yu Liu, Justus Ramtke, Nicola Beindorff, Frank Hofheinz, Avan Kader, Michael Mülleder, Kathrin Textoris‐Taube, Bernd Hamm, Dominik N. Müller, Robin Schmidt, Ralf Hauptmann, Heike Traub, Mathias Schannor, Lynn Jeanette Savic   +22 more
wiley   +1 more source

Machine learning enhanced immunologic risk assessments for solid organ transplantation

Scientific Reports
The purpose of this study was to enhance the prediction of solid-organ recipient and donor crossmatch compatibility by applying machine learning (ML). Prediction of crossmatch compatibility is complex and requires an understanding of the recipient and ...
Eric T. Weimer, Katherine A. Newhall
doaj   +1 more source

Evaluating the Clinical Relevance of Antibodies against Non-Human Leukocyte Antigen in Kidney Transplantation

Antibodies
Introduction: Kidney transplantation is the preferred modality of kidney replacement therapy for eligible patients with end-stage kidney disease (ESKD), given that it has been found to reduce mortality rates, improve quality of life, and is cost ...
Shiv Bhutani, Shelley Harris, Michelle Carr, Marcus Russell-Lowe, Judith Worthington, Henry H. L. Wu, Rajkumar Chinnadurai, Kay Poulton   +7 more
doaj   +1 more source