Results 171 to 180 of about 795,110 (304)

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

Beyond HLA: an exploratory pilot study of non-HLA antibodies, HLA sensitization, and GSTT1 genotype in platelet transfusion refractoriness. [PDF]

Front Immunol
Qi J, Zhu H, Wang M, Wang T, Li Y, Shang L, Chen L, Wang X, Shao J, Ma C, Xu H.   +10 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

A Tripartite Model for EBV‐Driven Multiple Sclerosis: B Cell Survival, Altered Self‐Presentation, and HLA‐DR15‐Restricted T Cell Cross‐Reactivity

iNew Medicine, EarlyView.
ABSTRACT This commentary integrates findings from three recent Cell reports to establish a unified mechanistic model of multiple sclerosis (MS) driven by the interplay between Epstein‐Barr virus (EBV) and the HLA‐DR15 genotype. EBV promotes CNS autoimmunity through three distinct but intersecting mechanisms.
Fang Zhu, Arnaud John Kombe Kombe, Tengchuan Jin   +2 more
wiley   +1 more source

Anti-HLA antibodies in lung transplantation: diagnostic pitfalls and future directions. [PDF]

Eur Respir Rev
Zajacova A, Revilla-Lopez E, Guney M, De Pelsmaeker S, Emonds MP, Naesens M, Saez-Gimenez B, Vanaudenaerde BM, Vos R.   +8 more
europepmc   +1 more source

Editorial: A hill of needs: Non-HLA antibodies and transplantation. [PDF]

Front Immunol, 2022
Otten HG, Dieudé M, Hickey MJ.
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

HLA Type and the Effect of HLA Antibodies in Kidney, Liver, and Pancreas Transplantation: A Review. [PDF]

Avicenna J Med Biotechnol
Zarei E, Roozbeh J, Nikoupour Deylami H, Nikeghbalian S, Ahrami M, Nasrollozoda F, Hashemzehi A, Hashemzaei M.   +7 more
europepmc   +1 more source

Complement and Non-Complement Binding Anti-HLA Antibodies Are Differentially Detected with Different Antigen Bead Assays in Renal Transplant Recipients. [PDF]

J Clin Med, 2023
Ouranos K, Panteli M, Petasis G, Papachristou M, Iosifidou AM, Iosifidou MA, Anastasiou A, Samali M, Stangou M, Theodorou I, Lioulios G, Fylaktou A.   +11 more
europepmc   +1 more source

Clinical value of non-HLA antibodies in kidney transplantation: Still an enigma?

, 2016
HLA antibodies play a major role in the recipient's immune response against the renal allograft and are an established risk factor for antibody-mediated rejection and subsequent impaired graft survival.
Krebber, Merle M, Verhaar, Marianne C, van Zuilen, Arjan D, Otten, Henny G, Michielsen, Laura A, Regenerative Medicine and Stem Cells, Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, CDL Celdiagnostiek, Infection & Immunity   +10 more
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