Results 101 to 110 of about 195,520 (337)

Association of HLA-B27 antigen with clinical and laboratory parameters in patients with juvenile idiopathic arthritis

, 2022
Adisa Čengić, Velma Selmanović, Sniježana Hasanbegović, Nedim Begić, Emina Karčić, Elma Fejzić   +5 more
openalex   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Nine Human Leukocyte Antigen (HLA) Class I Alleles are Omnipotent Against 11 Antigens Expressed in Melanoma Tumors

Cancer Informatics
Objective: Host immunogenetics (Human Leukocyte Antigen, HLA) play a critical role in the human immune response to melanoma, influencing both melanoma prevalence and immunotherapy outcomes.
Apostolos P Georgopoulos, Lisa M James, Matthew Sanders   +2 more
doaj   +1 more source

Public antigenic determinant on a family of HLA-B molecules. [PDF]

, 1979
Benjamin D. Schwartz, Lisa K. Luehrman, Glenn E. Rodey   +2 more
openalex   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Risk assessment of antibody-mediated damage based on the detection of HLA and non-HLA antibodies toward extracellular antigens before kidney transplantation

Frontiers in Immunology
IntroductionDonor-specific human leukocyte antigens antibodies (HLA-DSA) contribute toantibody-mediated rejection (ABMR) after kidney transplantation (KT).
Eulàlia Solà-Porta, Dolores Redondo-Pachón, Dolores Redondo-Pachón, Jorge Eguía-Núñez, Anna Buxeda, Anna Buxeda, José Luís Caro, Javier Gimeno, Luís Campuzano, Carla Burballa, Carla Burballa, Betty Chamoun, Sara Sanz-Ureña, Judith Federico-Vega, Elisenda Alari-Pahissa, Julio Pascual, Julio Pascual, María José Pérez-Sáez, María José Pérez-Sáez, Marta Crespo, Marta Crespo   +20 more
doaj   +1 more source

Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensitivity

Mediators of Inflammation, 2006
Background. HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU). Methods.
Maria Luisa Pacor, Gabriele Di Lorenzo, Pasquale Mansueto, Nicola Martinelli, Maria Esposito-Pellitteri, Paola Pradella, Laura Uxa, Gaetana Di Fede, GiovamBattista Rini, Roberto Corrocher   +9 more
doaj   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Suppression of allo-human leucocyte antigen (HLA) antibodies secreted by B memory cellsin vitro: intravenous immunoglobulin (IVIg) versusa monoclonal anti-HLA-E IgG that mimics HLA-I reactivities of IVIg [PDF]

, 2014
Dong Zhu, Mepur H. Ravindranath, Paul I. Terasaki, Tôru Miyazaki, Trung H.M. Pham, Vadim Jucaud   +5 more
openalex   +1 more source

Development and Use of Quick Reference Guides When Reviewing HLA Typing of Allogeneic Donors/ Cord Blood Units and Donor-Specific Antigens

, 2023
Renee Welch, Ashley M. Riley
openalex   +1 more source