Results 81 to 90 of about 24,724 (214)

Scalable Computation of Topological Abstractions for Scalar Data

Computer Graphics Forum, EarlyView.
Abstract Topological data analysis has become an important tool for large scale scalar data analysis and visualization, efficiently extracting the inherent structure and features of interest of the data. However, with growing dataset sizes and complexity, it is increasingly becoming infeasible to compute topological abstractions of interest in serial ...
M. Will, J. Lukasczyk, J. Tierny, A. Gyulassy, G. H. Weber, H. Carr, C. Garth   +6 more
wiley   +1 more source

Classified Boards and Corporate Environmental and Social Performance

Corporate Governance: An International Review, EarlyView.
ABSTRACT Research Question/Issue This study examines the relationship between classified boards and firms' environmental and social (E&S) performance. We ask whether the insulation associated with classified boards is related to firms' sustainability outcomes and whether external monitoring and investor horizon condition this relationship.
Lars Helge Haß, Georgios Loukopoulos, Nor Nabilah Binti Nazimuddin   +2 more
wiley   +1 more source

Confirmed efficacy of etoposide and dexamethasone in HLH treatment: Long term results of the cooperative HLH-2004 study [PDF]

, 2017
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome comprising familial/genetic HLH (FHL) and secondary HLH. In the HLH-94 study, with an estimated 5-year probability of survival (pSu) of 54% (95% confidence interval,
Aricó, Maurizio,, Filipovich, Alexandra H.,, Horne, AnnaCarin, Janka, Gritta,, Egeler, R Maarten, Rosso, Diego, Minkov, Milen, Rosso, Diego,, Horne, AnnaCarin,, AnnaCarin Horne, Lehmberg, Kai, R. Maarten Egeler, Montgomery, Scott, Ladisch, Stephan,, Alexandra H. Filipovich, Astigarraga, Itziar,, Minkov, Milen,, Jan-Inge Henter, Henter, Jan-Inge,, Kenneth L. McClain, McClain, Kenneth L, Diego Rosso, Ishii, Eiichi, McClain, Kenneth L.,, Bergsten, Elisabet, Bergsten, Elisabet,, Vasanta Nanduri, Ishii, Eiichi,, Egeler, R. Maarten,, Henter, Jan Inge, Maurizio Aricó, Aricó, Maurizio, Filipovich, Alexandra H, Janka, Gritta, Nanduri, Vasanta, Montgomery, Scott,, Gritta Janka, McClain, Kenneth L., Nanduri, Vasanta,, Egeler, R. Maarten, Elisabet Bergsten, Kai Lehmberg, Ladisch, Stephan, Filipovich, Alexandra H., Milen Minkov, Stephan Ladisch, Astigarraga, Itziar, Lehmberg, Kai,, Scott Montgomery, Henter, Jan-Inge, Itziar Astigarraga, Eiichi Ishii, Ishii, E, Egeler, RM, Astigarraga, I, Bergsten, E,, Janka, G, Ladisch, S, Horne, A,, Aricó, M, Filipovich, AH, Lehmberg, K   +61 more
core   +1 more source

An Atypical Skin Presentation of Adult‐Onset Still's Disease With Histological Description: A Case Report

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Adult‐onset Still's disease (AOSD) is an auto inflammatory disorder with a variable clinical presentation, and without a pathognomonic diagnostic test, characterized by high spiking fever, arthralgia/arthritis, a suggestive skin rash, elevated white blood cell count 10 G/L (> 80% neutrophils), elevated ferritin, with glycosylated ferritin < 20%
M. Nordmann, T. Mazza, S. Menzinger, G. Kaya, S. Bogiatzi, S. Vandenberghe‐Dürr, M. Blanchard, J. Stirnemann   +7 more
wiley   +1 more source

Primary Cutaneous Gamma‐Delta T‐Cell Lymphoma Complicating Long‐Standing Immunosuppressed Dermatomyositis

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Primary cutaneous gamma‐delta T‐cell lymphoma (PCGD‐TCL) is a rare cytotoxic lymphoma with key oncogenic drivers in the JAK/STAT pathway. Also primarily involving the subcutaneous adipose tissue, subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) is more frequently encountered in scenarios of autoimmune disorders.
Bennett Christie‐Nguyen, Youn H. Kim, David F. Fiorentino, Danielle Tartar, Ryanne Brown, Robert A. Novoa, Kerri E. Rieger   +6 more
wiley   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Polygenic mutations in the cytotoxicity pathway increase susceptibility to develop HLH immunopathology in mice

, 2016
International audienceHemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory disease. Inherited forms of HLH are caused by biallelic mutations in several effectors of granule-dependent lymphocyte-mediated cytotoxicity.
Sepulveda, Fernando, Maschalidi, Sophia, Fischer, Alain, de Saint Basile, Geneviève, Ménasché, Gaël, Garfa-Traore, Meriem, Garrigue, Alexandrine   +6 more
core   +1 more source

The Evolving Landscape of CHD Genetics: A Contemporary Guide to Genetic Testing and Management

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Congenital heart disease (CHD) is the most common birth defect, affecting an estimated 9.4/1000 infants globally. The genetics of CHD is complex, with most cases thought to have multifactorial aetiology, implicating both genetic and environmental factors.
Bridget R. O'Malley, Gary F. Sholler, Janine Smith, Gillian M. Blue   +3 more
wiley   +1 more source

Effect of MET on cAMP response of MLTC-1 cells to hLH or FSK/sub-hLH.

, 2019
(A), (C) Real-time recording of luminescence under stimulation of MLTC-1 cells by hLH or FSK/sub-hLH in the presence of 0 to 1000μM MET. (B), (D) Dose-dependent effects of MET determined on hLH and FSK/sub-hLH responses respectively, by the Area Under ...
Danièle Klett (252303), Thi Mong Diep Nguyen (776734), Laura Filliatreau (6796871), Yves Combarnous (252322)   +3 more
core   +1 more source

Hydrogels in Periodontal and Craniofacial Regeneration: Current Applications and Next‐Generation Biomaterials

Journal of Periodontal Research, EarlyView.
Hydrogel‐based therapies have proven to be valuable tools to address the unique regeneration challenges of complex multi‐domain periodontal and craniofacial tissues. This review highlights and classifies clinically approved and emerging hydrogel therapies indicated for the regeneration of periodontal and craniofacial tissues.
Z. Gouveia, M. Diba, B. T. Yilmaz, Jae‐Kook Cha, D. T. Wu, D. J. Mooney   +5 more
wiley   +1 more source