Results 101 to 110 of about 22,345 (254)

Clinical features and prognostic factors of adult systemic chronic active EBV disease: A retrospective analysis in Japan

British Journal of Haematology, EarlyView.
ALT and ferritin were adverse prognostic markers enabling risk stratification in adult systemic chronic active Epstein–Barr virus disease (sCAEBV). In hydroa vacciniforme lymphoproliferative disorder (HV‐LPD), Epstein–Barr virus (EBV) infection of CD4+ cells was associated with progression to sCAEBV.
Aika Fuseya, Masahide Yamamoto, Miwako Nishio, Ryo Kitabayashi, Akihiro Hirakawa, Hiroshi Yasui, Yoshihiro Umezawa, Keisuke Tanaka, Hayato Tamai, Yu Uemura, Kumi Oshima, Fumiaki Sano, Takehiko Mori, Ryuji Koike, Shouichi Ohga, Ayako Arai   +15 more
wiley   +1 more source

hlh-2, hlh-3 and hlh-4 act in ADL neurons to regulate srh-234 expression, and hlh-3 and hlh-4 appear to be transiently expressed in ADL.

, 2016
(A) Relative expression of srh-234p::gfp in adult hlh-2 and hlh-3 mutant animals compared to adult wild-type, or when fed hlh-3(RNAi) or hlh-4(RNAi) compared to control RNAi. Feeding RNAi was performed in sid-1(pk3321)him-5(e1409) mutants with the stably
Ari Winbush (651727), Jeremy Grubbs (3144156), Alexander M. van der Linden (240030), Aja McDonagh (3144159), Dominic Valdes (3144153), Matthew Gruner (651725)   +5 more
core   +1 more source

Classification, clinical manifestation and diagnosis of HLH

, 2018
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening immune dysregulation disease. It can be subdivided into a primary, genetic form and a secondary form that complicates diverse infections, autoimmune or autoinflammatory disorders, and ...
Volkmer, Benjamin, Ehl, Stephan, Pachlopnik Schmid, Jana; https://orcid.org/   +2 more
core   +1 more source

Confirmed efficacy of etoposide and dexamethasone in HLH treatment: Long term results of the cooperative HLH-2004 study [PDF]

, 2017
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome comprising familial/genetic HLH (FHL) and secondary HLH. In the HLH-94 study, with an estimated 5-year probability of survival (pSu) of 54% (95% confidence interval,
Aricó, Maurizio,, Filipovich, Alexandra H.,, Horne, AnnaCarin, Janka, Gritta,, Egeler, R Maarten, Rosso, Diego, Minkov, Milen, Rosso, Diego,, Horne, AnnaCarin,, AnnaCarin Horne, Lehmberg, Kai, R. Maarten Egeler, Montgomery, Scott, Ladisch, Stephan,, Alexandra H. Filipovich, Astigarraga, Itziar,, Minkov, Milen,, Jan-Inge Henter, Henter, Jan-Inge,, Kenneth L. McClain, McClain, Kenneth L, Diego Rosso, Ishii, Eiichi, McClain, Kenneth L.,, Bergsten, Elisabet, Bergsten, Elisabet,, Vasanta Nanduri, Ishii, Eiichi,, Egeler, R. Maarten,, Henter, Jan Inge, Maurizio Aricó, Aricó, Maurizio, Filipovich, Alexandra H, Janka, Gritta, Nanduri, Vasanta, Montgomery, Scott,, Gritta Janka, McClain, Kenneth L., Nanduri, Vasanta,, Egeler, R. Maarten, Elisabet Bergsten, Kai Lehmberg, Ladisch, Stephan, Filipovich, Alexandra H., Milen Minkov, Stephan Ladisch, Astigarraga, Itziar, Lehmberg, Kai,, Scott Montgomery, Henter, Jan-Inge, Itziar Astigarraga, Eiichi Ishii   +51 more
core   +1 more source

Scalable Computation of Topological Abstractions for Scalar Data

Computer Graphics Forum, EarlyView.
Abstract Topological data analysis has become an important tool for large scale scalar data analysis and visualization, efficiently extracting the inherent structure and features of interest of the data. However, with growing dataset sizes and complexity, it is increasingly becoming infeasible to compute topological abstractions of interest in serial ...
M. Will, J. Lukasczyk, J. Tierny, A. Gyulassy, G. H. Weber, H. Carr, C. Garth   +6 more
wiley   +1 more source

hlh-30 was necessary for survival during starvation and upon refeeding, and starvation promotes HLH-30 nuclear localization.

, 2019
(A) Schematic depicting starvation and refeeding assay. Gravid adults were bleached with alkaline hypochlorite to obtain eggs, which were transferred to buffered salt solution (M9). Upon hatching, larvae arrest development at the L1 stage.
Abhinav Diwan (759026), Haiyan Liu (51889), Rohan Khopkar (6697076), Ali Javaheri (4615927), Scot J. Matkovich (421129), Xiucui Ma (759024), John T. Murphy (226645), Brian M. Egan (6697070), Kartik Mani (6697079), Alexander Boyko (28471), Daniel Ory (2278774), Xuntian Jiang (2031358), Clara Oh (5567483), Samuel Ang (6697073), Alex Shaver (6697067), Kerry Kornfeld (226655), Sandeep Kumar (145759), Travis Mazer (136384)   +17 more
core   +1 more source

An Atypical Skin Presentation of Adult‐Onset Still's Disease With Histological Description: A Case Report

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Adult‐onset Still's disease (AOSD) is an auto inflammatory disorder with a variable clinical presentation, and without a pathognomonic diagnostic test, characterized by high spiking fever, arthralgia/arthritis, a suggestive skin rash, elevated white blood cell count 10 G/L (> 80% neutrophils), elevated ferritin, with glycosylated ferritin < 20%
M. Nordmann, T. Mazza, S. Menzinger, G. Kaya, S. Bogiatzi, S. Vandenberghe‐Dürr, M. Blanchard, J. Stirnemann   +7 more
wiley   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Monocyte/macrophages may exert prominent roles in macrophage activation syndrome

Annals of Hematology
Secondary Hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening complication mostly occurs in adult patients with rheumatic disease, infection or lymphoma. To adequately steer treatment, clear discrimination of sHLH entities is essential.
Dongfei Yin, Jingshi Wang, Zhao Wang
doaj   +1 more source

Third Allogeneic Stem Cell Transplantation in Children: A Multicenter Analysis From the Spanish GETH‐TC Pediatric Group

European Journal of Haematology, EarlyView.
ABSTRACT Third allogeneic hematopoietic stem cell transplantation (HSCT3) is rarely performed in pediatric patients and is associated with high toxicity and mortality. Data on outcomes in this setting remain scarce. We conducted a retrospective multicenter study within the Spanish GETH‐TC Pediatric group including 29 children and adolescents who ...
Luisa Sisinni, Sara Vinagre Enríquez, Marta Villalon Herrera, Mercedes Plaza Fornieles, Iván López Torija, Andrea Urtasun Erburu, Laura Alonso García, Alexandra Regueiro García, Maria Trabazo del Castillo, Eduardo J. Bardón‐Cancho, Odelaisy León‐Triana, Carla Miñarro Chacón, José Luís Fuster Soler, Antonio Pérez‐Martínez, Pascual Balsalobre López, Marta Gonzalez‐Vicent, Cristina Díaz de Heredia, on behalf of the GETH‐TC Pediatric Working Group   +17 more
wiley   +1 more source