Results 111 to 120 of about 24,724 (214)

An Australian Narrative Review of Adoptive Cellular Therapies in Malignancy: Expanding Indications, Referral Pathways and Safety Beyond Specialist Centres

Medical Journal of Australia, Volume 224, Issue 11, November 2026.
ABSTRACT Adoptive cellular therapies (ACT), including tumour‐infiltrating lymphocyte (TIL), T‐cell receptor‐engineered T (TCR‐T) cell and chimeric antigen receptor T‐cell (CAR‐T) therapies, represent an evolving class of immunotherapies with established efficacy in selected haematological malignancies and emerging applications in solid tumours ...
Sarah Childs, David Ma, Anthony Rodrigues, Jennifer Massey, Rasha Cosman, Venessa Chin, Laila Girgis, James Lynam, Peter Lau, Barbara Withers, Anthony M. Joshua, Ben Tran, Jayesh Desai, Simon J. Harrison, John Moore, Jia Liu   +15 more
wiley   +1 more source

Tracing Mantle Upwellings Beneath Changbaishan/Mount Paektu: New Insights From Transition Zone Discontinuity Structure

Geophysical Research Letters, Volume 53, Issue 19, 16 October 2026.
Abstract Intraplate volcanism in Northeast Asia, located in a distant back‐arc setting, challenges conventional models of mantle convection and volatile cycling. Using receiver function data from over 300 broadband stations, we image the mantle transition zone (MTZ) beneath the Changbaishan/Paektu volcano.
Cunrui Han, Weiqian Yu, James O. S. Hammond, David P. Dobson, He Tan, You Tian, Wei Wei   +6 more
wiley   +1 more source

Successful treatment of recurrent malignancy-associated hemophagocytic lymphohistiocytosis with a modified HLH-94 immunochemotherapy and allogeneic stem cell transplantation

, 2012
Acquired hemophagocytic lymphohistiocytosis (HLH) triggered by a known or still to be recognized malignancy is a life-threatening hyperinflammatory syndrome due to massive cytokine release from activated lymphocytes and macrophages. Malignancy-associated
Machaczka, Maciej, Hägglund, Hans,, Klimkowska, Monika, Nahi, Hareth, Karbach, Holger, Nahi, H,, Machaczka, M,, Hagglund, H,, Karbach, H, Klimkowska, M,   +9 more
core   +1 more source

Biological Insights Into Filopaludina bengalensis (Lamarck, 1822): An Ecologically and Economically Edible Freshwater Snail of South Asia

Aquaculture, Fish and Fisheries, Volume 6, Issue 5, October 2026.
ABSTRACT Freshwater snails play important ecological and socio‐economic roles across South Asia, yet basic biological information on Filopaludina bengalensis (Lamarck, 1822) (Gastropoda: Viviparidae) remains scarce. Growth performance, reproductive biology and embryonic development of F.
Alif Layla Bablee, Abu Ayub Ansary, Md. Naim Mahmud, Mashruka Jeba, Louise von Gersdorff Jørgensen, Md. Mehedi Alam, Neaz A. Hasan, Niels O. G. Jørgensen, Lars Hestbjerg Hansen, Mohammad Mahfujul Haque   +9 more
wiley   +1 more source

Incidence, Clinical Characteristics, Management, and Outcomes of Hematologic Immune‐Related Adverse Events Associated With Immune Checkpoint Inhibitors: A Single‐Center Japanese Retrospective Cohort Study

Cancer Medicine, Volume 15, Issue 10, October 2026.
This single‐center retrospective study evaluated hematologic immune‐related adverse events (irAEs) among 3371 patients treated with immune checkpoint inhibitors. Forty patients developed hematologic irAEs (1.2%); 85.0% of events were Grade 3 or higher, and the median time to onset was 12 weeks.
Ryo Yoshimaru, Hirotaka Nakamura, Yong‐Mei Guo, Kensuke Matsuda, Tetsuya Sakai, Yoshitaka Zenke, Kiyotaka Yoh, Kohei Shitara, Nobuaki Matsubara, Kenichi Harano, Hiromichi Nakajima, Nobuyuki Takahashi, Masafumi Ikeda, Takao Fujisawa, Saki Nakamura, Kenta Akie, Masayuki Ito, Masashi Wakabayashi, Junichiro Yuda   +18 more
wiley   +1 more source

A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice.

, 2015
International audienceThe impairment of cytotoxic activity of lymphocytes disturbs immune surveillance and leads to the development of hemophagocytic lymphohistiocytic syndrome (HLH).
Maschalidi, Sophia, Kurowska, Mathieu, Fischer, Alain, de Saint Basile, Geneviève, Di Santo, James P, Ménasche, Gaël, Sepulveda, Fernando E, Vosshenrich, Christian A. J., Garrigue, Alexandrine   +8 more
core   +1 more source

The effectiveness of etoposide-containing chemotherapy regimens in the initial treatment of Hemophagocytic Syndrome in pregnancy

Hematology
Objective To summarize the clinical characteristics, treatment outcomes, and prognosis of pregnant patients with hemophagocytic lymphohistiocytosis (HLH), and to evaluate the efficacy of chemotherapy regimens containing etoposide (VP16) in these patients
Jie Wang, Na Wei, Jingshi Wang, Lin Wu, Hongli Hu, Zhao Wang   +5 more
doaj   +1 more source

Effect of A-769662 on intracellular cAMP response of MLTC-1 cells to hLH or FSK/sub-hLH.

, 2019
(A), (C) Real-time recording of luminescence under stimulation of MLTC-1 cells by hLH and FSK/sub-hLH respectively in presence of 0 to 1000μM A-769662. (B), (D) Dose-dependent effects of A-769662 on hLH and FSK/sub-hLH responses respectively, determined ...
Danièle Klett (252303), Thi Mong Diep Nguyen (776734), Laura Filliatreau (6796871), Yves Combarnous (252322)   +3 more
core   +1 more source

Unusual Hemodynamic Presentation of Pediatric Kikuchi‐Fujimoto Disease: Persistent Sinus Bradycardia and Vasopressor‐Dependent Hypotension

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Kikuchi‐Fujimoto disease rarely presents with vasopressor‐dependent hypotension requiring pediatric intensive care despite preserved cardiac function. This case highlights the importance of early excisional lymph node biopsy for timely diagnosis and appropriate management of children with unexplained hemodynamic instability and necrotizing ...
Abdulla Alfraij, Fatma Mothafar, Wasmi Alfadhli, Ali Ashkanani, Lujain A. Kamal, Esmail Redha, Abdulrahman Aldaithan   +6 more
wiley   +1 more source

Hämophagozytische Lymphohistiozytose (HLH)

Die Hämophagozytische Lymphohistiozytose (HLH) und das Makrophagenaktivierungssyndrom (MAS-HLH) sind hyperferritinämische Hyperinflammationssyndrome. Sie sind gekennzeichnet durch einen Zytokinsturm aberrant aktivierter Makrophagen und T-Zellen.
Schenk, Thomas, Beutel, Karin, Schweizerische Gesellschaft für Hämatologie, Girschikofsky, Michael, Maschmeyer, Georg, Ehl, Stephan, Weber, Thomas, Schweizerische Gesellschaft für Medizinische Onkologie, Gesellschaft für Pädiatrische Onkologie und Hämatologie, Janka-Schaub, Gritta, La Rosée, Paul, Lehmberg, Kai, Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie, Birndt, Sebastian, Pachlopnik Schmid, Jana, Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie   +15 more
core   +1 more source