Results 131 to 140 of about 22,345 (254)

Diagnostic criteria for HLH used in the HLH-2004 trial^*.

, 2019
The diagnosis of HLH is established when 5 of the 8 criteria listed below are fulfilled.
Jacqueline De Gottardi (8201541), Alicia Rovo (121163), Anne Angelillo-Scherrer (591364), Matteo Montani (8201544), Annalisa Berzigotti (387331)   +4 more
core   +1 more source

Herpes Simplex Virus Hepatitis: An Overlooked Cause of Acute Liver Failure Across a Broad Spectrum of Immunocompromise

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Background and Aims Herpes simplex virus (HSV) infection is common worldwide, but hepatic involvement is rare. HSV hepatitis is an uncommon yet frequently catastrophic cause of acute hepatitis and acute liver failure (ALF), accounting for < 1% of ALF cases while carrying very high mortality when diagnosis and antiviral therapy are delayed ...
Mario U. Mondelli, Serena Ludovisi, Angela Di Matteo, Gülşen Özkaya Şahin, William Irving, European Society of Clinical Microbiology and Infectious Diseases Study Group for Viral Hepatitis (ESGVH)   +5 more
wiley   +1 more source

Linfohistiocitosis hemofagocítica (HLH) en pacientes pediátricos. Experiencia de una institución

, 2022
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening and generally underdiagnosed clinical entity. This syndrome describes patients with severe systemic hyperinflammation.
Merhar, C, Sossi, M.E., Morici, M., Segovia Gira, C.V., Deana, Alejandra, Sanchez Tovar, E, Riccheri, C.   +6 more
core  

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, Volume 30, Issue 3, Page 389-396, June 2026.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Methotrexate Toxicity in a Patient With Renal Failure Despite a Normal Methotrexate Concentration: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Methotrexate (MTX) is a folate antagonist widely used as a disease‐modifying antirheumatic drug (DMARD) in rheumatoid arthritis (RA), as well as in several malignancies and autoimmune disorders. Although low‐dose MTX (5–20 mg/week) is generally considered safe, it has a narrow therapeutic index, and toxicity can occur even at therapeutic doses,
Fatemeh Afra, Mahshad Ghoddusi, Mahsa Mottahedi, Maryam Albaji, Samira Kafan, Roya Saedpanah, Amir Shokri, Elham Nazar   +7 more
wiley   +1 more source

A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice.

, 2015
International audienceThe impairment of cytotoxic activity of lymphocytes disturbs immune surveillance and leads to the development of hemophagocytic lymphohistiocytic syndrome (HLH).
Maschalidi, Sophia, Kurowska, Mathieu, Fischer, Alain, de Saint Basile, Geneviève, Di Santo, James P, Ménasche, Gaël, Sepulveda, Fernando E, Vosshenrich, Christian A. J., Garrigue, Alexandrine   +8 more
core   +1 more source

Hämophagozytische Lymphohistiozytose (HLH)

Die Hämophagozytische Lymphohistiozytose (HLH) und das Makrophagenaktivierungssyndrom (MAS-HLH) sind hyperferritinämische Hyperinflammationssyndrome. Sie sind gekennzeichnet durch einen Zytokinsturm aberrant aktivierter Makrophagen und T-Zellen.
Schenk, Thomas, Beutel, Karin, Schweizerische Gesellschaft für Hämatologie, Girschikofsky, Michael, Maschmeyer, Georg, Ehl, Stephan, Weber, Thomas, Schweizerische Gesellschaft für Medizinische Onkologie, Gesellschaft für Pädiatrische Onkologie und Hämatologie, Janka-Schaub, Gritta, La Rosée, Paul, Lehmberg, Kai, Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie, Birndt, Sebastian, Pachlopnik Schmid, Jana, Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie   +15 more
core   +1 more source

From diagnosis to treatment: a successful case of haemophagocytic lymphohistiocytosis of presumed bacterial aetiology in an adult.

European Journal of Case Reports in Internal Medicine
Haemophagocytic lymphohistiocytosis (HLH) affects patients across all age groups and can be classified as either primary HLH (P-HLH) or secondary HLH (S-HLH).
Catarina Pestana Santos, Daniela Cruz, Bruno Gonçalves de Sousa, Tiago Judas   +3 more
doaj   +1 more source

Diagnosing and treating hemophagocytic lymphohistiocytosis in the tropics: Systematic review from the indian subcontinent [PDF]

Acta Medica Academica, 2012
Background. Hemophagocytic lymphohistiocytosis (HLH) is a catastrophicsyndrome of unrestrained immune activation. Evaluation and management of HLH in the tropics is challenging. Objectives.
Srinivas Rajagopala, Navneet Singh
doaj  

Effect of fluoxetine in hLH or FSK/sub-hLH -promoted steroid production in MLTC-1 and primary Leydig cells.

, 2019
(A), (B) MLTC-1 cells were preincubated with or without FLX (or MET, or A-769662) for 1 hour and then the cells were stimulated for 3 hours with hLH or FSK/sub-hLH before progesterone productions were measured.
Danièle Klett (252303), Thi Mong Diep Nguyen (776734), Laura Filliatreau (6796871), Yves Combarnous (252322)   +3 more
core   +1 more source