Results 131 to 140 of about 29,559 (185)

Drug Target Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Atrial Fibrillation.

Cardiology
Li F, Mei Y, Wu Q, Wu X.
europepmc   +1 more source

Graft protective effects and donor-specific antibody suppression by CD4⁺CD25⁺Foxp3⁺ regulatory T cell induced by HMG-CoA reductase inhibitor rosuvastatin in a murine heart transplant model. [PDF]

J Cardiothorac Surg
Iguchi K, Yamamoto Y, Uchiyama M, Masaoka H, Nakamura M, Shizuka H, Imazuru T, Shimokawa T.   +7 more
europepmc   +1 more source

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Rhabdomyolysis and HMG-CoA Reductase Inhibitors

Annals of Pharmacotherapy, 2001
OBJECTIVE: To review rhabdomyolysis and discuss the role of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) and their interactions with other agents in precipitating this condition, and to present case reports of statin-induced rhabdomyolysis.
James P Wilson
exaly   +3 more sources

HMG-CoA reductase inhibitors

Natural Product Reports, 1993
Since in humans the greater part of the cholesterol in the body is synthesized de novo in the liver and intestine, the search for drugs to inhibit cholesterol biosynthesis has long been pursued as a means to lower the level of plasma cholesterol and so help to prevent and treat atherosclerosis.
A, Endo, K, Hasumi
openaire   +3 more sources

HMG CoA reductase inhibitors

Current Opinion in Lipidology, 1994
Beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (HMG CoA RIs) are now being prescribed in many different countries, and the number of patients treated with these compounds is estimated to be over 1.5 million. The spectrum of indications for these drugs is enlarging.
openaire   +3 more sources

Regulation of HMG-CoA Reductase

1976
Publisher Summary This chapter discusses the regulation of HMG-CoA reductase, which catalyzes the rate-limiting reaction of hepatic sterol synthesis. Both mitochondrial and extramitochondrial forms of acetoacetyl-CoA thiolase and the HMG-CoA synthase are present in liver tissue.
V W, Rodwell, J L, Nordstrom, J J, Mitschelen   +2 more
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HMG-CoA reductase inhibitors

2001
Publisher Summary This chapter focuses on the 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase enzyme that is known as the rate limiting enzyme in the cholesterol biosynthetic pathway. Today, HMG-CoA reductase inhibitors (statins) account for the large majority of prescriptions for lipid-lowering drugs in most countries.
D R, Illingworth, J A, Tobert
openaire   +2 more sources

HMG-CoA Reductase Inhibitors and Myotoxicity

Drug Safety, 2000
The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors specifically inhibit HMG-CoA reductase in the liver, thereby inhibiting the biosynthesis of cholesterol. These drugs significantly reduce plasma cholesterol level and long term treatment reduces morbidity and mortality associated with coronary heart disease.
M, Ucar, T, Mjörndal, R, Dahlqvist
openaire   +2 more sources

HMG-CoA reductase inhibitors and the kidney

Current Hypertension Reports, 2005
HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors (statins) have been shown to reduce serum cholesterol and cardiovascular morbidity and mortality. The mechanisms of these beneficial effects are reviewed. Altered inflammatory responses and improved endothelial function mediated by statins are thought to be, in part, responsible for the ...
Vito M, Campese, Bassel, Hadaya, Josephine, Chiu   +2 more
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Phosphorylation and degradation of HMG CoA reductase

Advances in Enzyme Regulation, 1989
3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase is the limiting enzyme step in cholesterol formation in mammalian liver and other tissues. It is a glycoprotein of 97,000 daltons embedded in the endoplasmic reticulum with a long cytoplasmic extension that is the site of catalytic conversion of HMG CoA to mevalonate.
S J, Miller, R A, Parker, D M, Gibson
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