Results 61 to 70 of about 200,536 (178)

A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1

Nature Communications
Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis.
Jeffrey M. Rybak, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Ana C. O. Souza, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno, Josie E. Parker, Steven L. Kelly, Hannah M. Snell, Christina A. Cuomo, P. David Rogers, Jarrod R. Fortwendel   +16 more
doaj   +1 more source

Mechanisms for cholesterol homeostasis in rat jejunal mucosa: effects of cholesterol, sitosterol, and lovastatin

Journal of Lipid Research, 2001
The effects of feeding cholesterol, sitosterol, and lovastatin on cholesterol absorption, biosynthesis, esterification, and LDL receptor function were examined in the rat jejunal mucosa.
Lien B. Nguyen, Sarah Shefer, Gerald Salen, G.S. Tint, Frank Ruiz, John Bullock   +5 more
doaj   +1 more source

CAFs‐mediated histone lactylation reprograms cholesterol metabolism in colorectal cancer to drive CD8+ T cell immunosuppression

The Journal of Pathology, EarlyView.
Abstract The progression of colorectal cancer (CRC) is critically regulated by cancer‐associated fibroblasts (CAFs) within the tumor microenvironment (TME), yet the specific molecular mechanisms by which CAFs influence CRC remain unclear. This study reveals the mechanism by which CAFs promote CRC malignant progression and immune suppression through ...
Huachi Li, Jun Hu, Lei Huang, Zihao Wang, Haoran Tao, Feng Cao, Min Xie   +6 more
wiley   +1 more source

Regulatory effects of sterols and bile acids on hepatic 3-hydroxy-3-methylglutaryl CoA reductase and cholesterol 7α-hydroxylase in the rat

Journal of Lipid Research, 1973
Specific activities of the hepatic microsomal enzymes 3-hydroxy-3-methylglutaryl CoA (HMG CoA) reductase and cholesterol 7α-hydroxylase were studied in rats fed sterols and bile acids.
S. Shefer, S. Hauser, V. Lapar, E.H. Mosbach   +3 more
doaj   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Features of the hmg 1 subfamily of genes encoding HMG-CoA reductase in potato

, 1995
Article on the features of the hmg 1 subfamily of genes encoding HMG-CoA reductase in ...
Dixon, R. A., Korth, Kenneth L., Stermer, Bruce A., Bhattacharyya, Madan Kumar, Paiva, Nancy L.   +4 more
core   +1 more source

Diurnal variation of HMG CoA reductase activity in rat intestine

Journal of Lipid Research, 1972
HMG CoA reductase activity of rat intestinal mucosa has a diurnal rhythm which coincides with the diurnal variation of the hepatic HMG CoA reductase but has a lower amplitude. The rhythmic variation of the intestinal reductase was present in both jejunal
S. Shefer, S. Hauser, V. Lapar, E.H. Mosbach   +3 more
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

MYC Phosphorylation, Activation, and Tumorigenic Potential in Hepatocellular Carcinoma Are Regulated by HMG-CoA Reductase

, 2011
MYC is a potential target for many cancers but is not amenable to existing pharmacologic approaches. Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) by statins has shown potential efficacy against a number of cancers ...
Hua Fan-Minogue, David I. Bellovin, Julia Arzeno, Aleksey Yevtodiyenko, Qiwei Yang, Zhongwei Cao, Sanjiv Sam Gambhir, Dean W. Felsher   +7 more
core   +1 more source

Effect of endotoxin on cholesterol biosynthesis and distribution in serum lipoproteins in Syrian hamsters.

Journal of Lipid Research, 1993
Infection and inflammation increase serum triglyceride and cholesterol levels in rodents and rabbits. Endotoxin (LPS) has been used as a model of infection and its effects on triglyceride metabolism have been previously characterized.
Kenneth R. Feingold, Ingibjorg Hardardottir, Riaz Memon, Eveline J.T. Krul, Arthur H. Moser, John M. Taylor, Carl Grunfeld   +6 more
doaj   +1 more source