Results 61 to 70 of about 29,559 (185)

Patients on statins with elevated transaminases: Frequency of follow‐up creatine kinase testing and gastroenterology referral

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2917-2923, August 2026.
Abstract Purpose To quantify how often creatine kinase (CK) is measured after newly elevated aminotransferases in statin users, and whether absent CK data are associated with gastroenterology (GI) referrals. Methods Retrospective chart review of adult outpatients on statins with a first alanine/aspartate aminotransferase (ALT/AST) elevation during a 5 ...
Faris Shweikeh, Anas Kartoumah, Rajshri Joshi, Anjali Nadihaan, Mohammed Mouchli, Inderprit Singh   +5 more
wiley   +1 more source

HMG-CoA reductase inhibition promotes neurological recovery, perilesional tissue remodeling and contralesional pyramidal tract plasticity after focal cerebral ischemia

Frontiers in Cellular Neuroscience, 2014
3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are widely used for secondary stroke prevention. Besides their lipid-lowering activity, pleiotropic effects on neuronal survival, angiogenesis and neurogenesis have been described.
Ertugrul eKilic, Raluca eReitmeir, Ulkan eKilic, Ahmet Burak Caglayan, Mustafa Caglar Beker, Taha eKelestemur, Muhsine Sinem Ethemoglu, Gurkan eOzturk, Dirk M. Hermann   +8 more
doaj   +1 more source

Uncovering Coenzyme Q10‐Related Genetic Determinants of Statin‐Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 475-483, August 2026.
Statin‐associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome‐wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10
Da Hoon Lee, Yoon‐A Park, Yubin Song, Ji‐Min Han, Kyung Hee Choi, Myeong Gyu Kim, Hye Sun Gwak   +6 more
wiley   +1 more source

In vitro screening of angiotensin converting enzyme and hydroxymethylglutaryl-coenzyme A reductase inhibitory activities in lactic acid bacteria and yeasts isolated from fermented sorghum gruels

BioTechnologia
Background 3-hydroxyl-3-methylglutaryl-coenzyme A (HMG-CoA) reductase and angiotensin converting enzyme (ACE) are implicated in the pathogenesis of hyperlipidemia and hypertension, which are oxidative-stress linked conditions of public health importance.
Praise Temilade Ozabor, Johnson Olaleye Oladele, Ilesanmi Festus Fadahunsi   +2 more
doaj   +1 more source

Lovastatin treatment inhibits sterol synthesis and induces HMG-CoA reductase activity in mononuclear leukocytes of normal subjects.

Journal of Lipid Research, 1989
The mechanism by which competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase decrease serum cholesterol is incompletely understood.
B G Stone, C D Evans, W F Prigge, W C Duane, R L Gebhard   +4 more
doaj   +1 more source

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source

Influence of extraction methods of bay leaves (Syzygium polyanthum) on antioxidant and HMG-CoA Reductase inhibitory activity

Heliyon, 2019
Objective: Bay leaf, one of the plants in Indonesia that has been shown to have activities to reduce cholesterol in the blood. HMG-CoA Reductase inhibition is one of many mechanisms in lowering the level of cholesterol in the blood. Here, we reported the
Lanny Hartanti, Stefania Maureen Kasih Yonas, Josianne Jacqlyn Mustamu, Sumi Wijaya, Henry Kurnia Setiawan, Lisa Soegianto   +5 more
doaj   +1 more source

Multi‐Target Anti‐Obesity Potential of Coula edulis Nut Extract in High‐Fat Diet‐Induced Obesity in Rats

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
This study evaluated the multi‐target anti‐obesity effects of Coula edulis nut extract (CEE) in high‐fat diet‐induced obese Wistar rats. Following 4 weeks of obesity induction, rats received oral CEE at 1 or 2 g/kg body weight, or orlistat for 5 weeks under continued high‐fat diet or normal diet conditions.
Chidimma Emmanuel Ibeneme, Item Justin Atangwho, Godwin Eneji Egbung, Diana Ochuole Odey, Chinedum Ekeleme Martins, Uket Nta Obeten, Wilson Arong Obio, Louisiane Patrick Nangah, Emmanuel O. Ibeneme, Daniel Ejim Uti   +9 more
wiley   +1 more source

Influence of simvA glyzin on expression and inhibition of hmg-coa reductase in rats liver

Атеросклероз, 2015
Activity, level of protein and mRNA HMG-CoA reductase were investigated in rats liver treated with simvastatin (SV), its complex compound with glycyrrhizic acid – simvaglyzin (SVG) and glycyrrhizic acid alone.
Yu. I. Ragino, V. A. Vavilin, E. M. Stakhneva, N. F. Salakhutdinov, O. G. Safronova, A. B. Shintyapina, V. V. Lyakhovich, Yu. P. Nikitin   +7 more
doaj  

Ziziphus jujube Fruit Supplementation Improves Liver Enzymes, Lipid Profile, and Hepatic Steatosis but Not Fasting Blood Glucose in Patients With NAFLD: A Randomized Controlled Trial

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Daily supplementation with Ziziphus jujube fruit improved liver enzymes, lipid profile, and hepatic steatosis in patients with non‐alcoholic fatty liver disease (NAFLD), potentially through its antioxidant, anti‐inflammatory, and lipid‐modulating properties.
Ronak Borzooei, Karim Parastouei, Maryam Taghdir, Mojtaba Sepandi, Mohammad Ali Abyazi Heris   +4 more
wiley   +1 more source