Results 61 to 70 of about 36,764 (181)

Isolated Gamma‐Glutamyltransferase Elevation During Statin Therapy: A Diagnostic Pitfall and a Stepwise Management Framework to Prevent Unnecessary Discontinuation

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT The management of patients with isolated gamma‐glutamyltransferase (GGT) elevation during statin therapy remains a common clinical dilemma due to the unclear relevance to hepatotoxicity. We report a case of a patient with coronary artery disease who developed persistent isolated GGT elevation (> 100 U/L) while on atorvastatin, with normal ...
Jun Yang, Yanling He, Zhengyong Zhang
wiley   +1 more source

HMG-CoA reductase, cholesterol 7α-hydroxylase, LCAT, ACAT, LDL receptor, and SRB-1 in hereditary analbuminemia

, 2003
HMG-CoA reductase, cholesterol 7α-hydroxylase, LCAT, ACAT, LDL receptor, and SRB-1 in hereditary analbuminemia.BackgroundHereditary analbuminemia is associated with hypercholesterolemia, which has been shown to be primarily caused by increased ...
Liang, Kaihui, Vaziri, Nosratola D.
core   +1 more source

Moderate Intensity Statins Plus Ezetimibe Combination Therapy Versus High Intensity Statins Monotherapy After Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis

Clinical Cardiology, Volume 49, Issue 6, June 2026.
ABSTRACT Background High‐intensity statins are standard therapy after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS), yet tolerability concerns and residual cardiovascular risk remain important challenges. Moderate‐intensity statin therapy combined with ezetimibe has emerged as a potential alternative, although its ...
Emad Uddin Sajid, Muhammad Hasnain Azeem, Alishba Fatima, Syeda Masooma Jafri, Danish Hassan, Taha Ibrahim, Kashish Zehra Manjee, Syed Rayyan Ahmed, Tooba Ali, Rida Shakeel, Muhammad Usman, Raghabendra Kumar Mahato, Danish Bawa   +12 more
wiley   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Molecular Docking Kandungan Senyawa Biji Pepaya (Carica Papaya L.) Terhadap Enzim Hmg-Coa Reductase Sebagai Antihiperkolesterolemia [PDF]

, 2018
Biji pepaya (Carica papaya L.) memiliki beberapa kandungan senyawa yang diduga memiliki efek penurunan kadar kolesterol dengan mekanisme sebagai penghambat enzim HMG-CoA reductase.
Hariyanti, Hariyanti, Karinah, Mutia, Rachmania, Rizky Arcinthya   +2 more
core  

HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015)

, 2016
Introduction: Statins are remarkably safe and efficient medications that are the mainstay of hypercholesterolemia treatment and have proven to be an invaluable tool to lower the risk of acute cardiovascular events.
Maria João Ramos (47524), Eduardo Filipe Oliveira (3107274), Natércia Fernandes Brás (3107277), Diogo Santos-Martins (1331889), António Meireles Ribeiro (3107268), Sérgio Filipe Sousa (2482099), Pedro Alexandrino Fernandes (473128), Nuno Sousa Cerqueira (3107271)   +7 more
core   +1 more source

The Dynamic Evolution of Lipid Profiles Following Transjugular Intrahepatic Portosystemic Shunt in Patients With Liver Cirrhosis

Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 150-159, June 2026.
Cirrhosis is frequently accompanied by varying degrees of lipid profile abnormalities. This study confirms that these profiles are differentially affected by disease etiology and progressively worsen—with significant reductions in TC, HDL‐C, and LDL‐C—as liver disease severity increases. TIPS improves lipid profiles, particularly by increasing HDL‐C in
Jiamin Xu, Qinnian Li, Lagan Kumar Manandhar, Bilian Zhu, Chenrui Zhang, Weimin Bao, Yingmei Tang   +6 more
wiley   +1 more source

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto, Lucia Buccarello, Giuseppe Carota, Rocco Salvatore Calabrò, Carmela Rifici, Emanuela Esposito, Alessio Ardizzone, Giuseppe Caruso   +7 more
wiley   +1 more source

Uji potensi ekstrak etanol daun salam (syzygium polyanthum) hasil perkolasi terhadap aktivitas inhibisi enzim hmg-coa reductase secara in vitro [PDF]

, 2018
Daun Salam (Syzygium polyanthum) dikenal memiliki aktivitas antikolesterol. Daun salam banyak diteliti secara in vivo dalam menurunkan kolesterol, namun belum ada informasi ilmiah mengenai mekanisme kerja inhibisi enzim HMG-CoA Reductase dari ekstrak ...
Yonas, Stefania Maureen Kasih
core