Results 41 to 50 of about 200,536 (178)

The effect of anti‐seizure medications on exposure to statins: A systematic review and meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objectives Antiseizure medications (ASMs) can reduce the efficacy of statin treatment, partly due to reduction in statin concentrations. In this systematic review and network meta‐analysis (NMA), we compared the effects of ASMs and the prototypical enzyme inducer rifampin on statin exposure.
Sharon Valiyev Huino, Hagar Cohen, Bruria Hirsh Raccah, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +5 more
wiley   +1 more source

Regulation of gene expression and synthesis and degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by micellar cholesterolin CaCo-2 cells.

Journal of Lipid Research, 1991
To investigate whether, and by what mechanisms, luminal (dietary) cholesterol regulates cholesterol synthesis in human intestinal cells, HMG-CoA reductase activity, gene expression, synthesis, and degradation were investigated in CaCo-2 cells exposed to ...
FJ Field, T Shreves, D Fujiwara, S Murthy, E Albright, SN Mathur   +5 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Phytochemistry, Chemotypic Diversity and Antimicrobial Potential of Essential Oils From Native Aromatic Plants of the Americas: A Systematic Review

Flavour and Fragrance Journal, EarlyView.
This review bridges ancestral indigenous knowledge with modern pharmacology, summarizing the phytochemistry and antimicrobial properties of essential oils from seven native American species. It highlights their significant activity against bacterial, fungal and parasitic pathogens, emphasizing their potential as sustainable therapeutic and agricultural
Arley Rey Páez, Mozaniel Santana de Oliveira, João Paulo Viana Leite   +2 more
wiley   +1 more source

Biochemical existence of HMG-CoA reductase, and the effects of simvastatin and simvastatin Na⁺ on the protein expression of HMG-CoA reductase and p-HMG-CoA reductase.

, 2013
(A) Biochemical existence of HMG-CoA reductase in porcine liver, porcine coronary artery (endothelium-denuded) and human left internal mammary artery (endothelium-denuded). Beta actin was used as loading control.
Yiu Wa Kwan (362888), Siu Kai Kong (422495), Simon Ming Yuen Lee (362891), Ho Pui Ho (422498), Shun Wan Chan (362889), George Pak Heng Leung (362890), Sai Ming Ngai (422496), Song Wan (422497), Alice Lai Shan Au (422492), John Hok Keung Yeung (182813), Maggie Pui Man Hoi (362887), Rachel Wai Sum Li (422494), Christina Chui Wa Poon (422493), Sai Wang Seto (384961), Qian Zhang (49333)   +14 more
core   +1 more source

Protective Effects of Fenugreek and Stevia Extracts on Dexamethasone‐Induced Testicular Damage in a Rat Model

Food Safety and Health, EarlyView.
Fenugreek and stevia extracts protect against dexamethasone‐induced testicular damage in male rats by enhancing antioxidant defenses, improving sperm quality, and restoring hormonal balance, highlighting their potential as natural therapeutics for preventing corticosteroid‐induced reproductive toxicity.
Mosab Gad, Medhat Ibrahim A. Omar, Mohammed I. Elkhateeb, Ahmed A. Zaky   +3 more
wiley   +1 more source

Cyclic AMP-sensitive activation of hepatic sterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Journal of Lipid Research, 1978
We previously showed that preincubation of a 10,000 g supernatant (S(10)) from rat liver for 20 min at 37 degrees C dramatically increased the subsequent incorporation of [(14)C]acetate into sterols.
C D Goodwin, S Margolis
doaj   +1 more source

Biosynthesis of (S)-HMG-CoA and purification and characterization of HMG-CoA reductase from the archaeon Haloferax volcanii

, 1995
Two methods have been developed for use in the continuing investigation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. A method which employs Pseudomonas mevalonii HMG-CoA reductase for the enzymic synthesis of (S)-HMG-CoA, the physiologic
Bischoff, Kenneth Mark
core   +1 more source

Reversible inactivation-reactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase of rat intestine.

Journal of Lipid Research, 1984
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in the ileum of rats was inactivated by Mg2+-ATP and reversibly reactivated by cytoplasmic activator from the liver. The mevalonate kinase reaction was presumably not involved in this inactivation.
H Oku, T Ide, M Sugano
doaj   +1 more source

Molecular Docking of Red Betel (Piper crocatum Ruiz & Pav) Bioactive Compounds as HMG-CoA Reductase Inhibitor

Jurnal Kimia Sains dan Aplikasi, 2021
Cholesterol plaque buildup in artery walls occurs due to oxidation of Low-Density Lipoprotein (LDL) molecules by free radicals, which are a risk factor for coronary heart disease. Piper crocatum contains active compounds that can act as HMG-CoA reductase
Bella Fatima Dora Zaelani, Mega Safithri, Dimas Andrianto   +2 more
doaj   +1 more source