Results 21 to 30 of about 36,764 (181)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Patients on statins with elevated transaminases: Frequency of follow‐up creatine kinase testing and gastroenterology referral

British Journal of Clinical Pharmacology, EarlyView.
Abstract Purpose To quantify how often creatine kinase (CK) is measured after newly elevated aminotransferases in statin users, and whether absent CK data are associated with gastroenterology (GI) referrals. Methods Retrospective chart review of adult outpatients on statins with a first alanine/aspartate aminotransferase (ALT/AST) elevation during a 5 ...
Faris Shweikeh, Anas Kartoumah, Rajshri Joshi, Anjali Nadihaan, Mohammed Mouchli, Inderprit Singh   +5 more
wiley   +1 more source

Biochemical existence of HMG-CoA reductase, and the effects of simvastatin and simvastatin Na⁺ on the protein expression of HMG-CoA reductase and p-HMG-CoA reductase.

, 2013
(A) Biochemical existence of HMG-CoA reductase in porcine liver, porcine coronary artery (endothelium-denuded) and human left internal mammary artery (endothelium-denuded). Beta actin was used as loading control.
Yiu Wa Kwan (362888), Siu Kai Kong (422495), Simon Ming Yuen Lee (362891), Ho Pui Ho (422498), Shun Wan Chan (362889), George Pak Heng Leung (362890), Sai Ming Ngai (422496), Song Wan (422497), Alice Lai Shan Au (422492), John Hok Keung Yeung (182813), Maggie Pui Man Hoi (362887), Rachel Wai Sum Li (422494), Christina Chui Wa Poon (422493), Sai Wang Seto (384961), Qian Zhang (49333)   +14 more
core   +1 more source

Uncovering Coenzyme Q10‐Related Genetic Determinants of Statin‐Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program

Clinical Pharmacology &Therapeutics, EarlyView.
Statin‐associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome‐wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10
Da Hoon Lee, Yoon‐A Park, Yubin Song, Ji‐Min Han, Kyung Hee Choi, Myeong Gyu Kim, Hye Sun Gwak   +6 more
wiley   +1 more source

Differences in mechanisms of modulation between rat liver cholesterol 7α-hydroxylase and HMG-CoA reductase

, 1985
The effects of microsomal HMG-CoA reductase kinase, cytosolic phosphoprotein phosphatase and cytosolic, thiol-dependent cholesterol 7α-hydroxylase stimulatory protein on purified cholesterol 7α-hydroxylase and HMG-CoA reductase from rat liver were ...
Bodil Lidström-Olsson, Lidström-Olsson, Bodil   +1 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

The impact of HMG CoA reductase on esterases and leptin [PDF]

, 2016
Cilj ovog rada bio je ispitati utjecaj inhibitora HMG –CoA reduktaze na esteraze i leptin. Inhibitori HMG – CoA reduktaze ili statini su lijekovi koji se često koriste u liječenju hiperkolesterolemije. HMG – CoA reduktaza je enzim koji katalizira ključni
Gredelj, Maja
core  

Recent Perspectives on Phytochemical Profile, Pharmacological Activities, and Industrial Applications of Guava (Psidium guajava)

Food Safety and Health, EarlyView.
Psidium guajava leaves contain potent bioactive compounds like quercetin, myricetin, and triterpenoids that show antioxidant, antidiabetic, anti‐inflammatory, and anticancer effects. They act by modulating NF‐κB, PPARγ, and α‐glucosidase and by inducing apoptosis and cell cycle arrest.
Muhammad Waqar, Sehrish Jabbar, Qudrat Ullah, Farhang Hameed Awlqadr, Muhammad Tayyab Arshad, Md. Sakhawot Hossain, Sammra Maqsood, Ali Ikram, Ammar Ahmad Khan, Worawan Panpipat, Manat Chaijan   +10 more
wiley   +1 more source

Protective Effects of Fenugreek and Stevia Extracts on Dexamethasone‐Induced Testicular Damage in a Rat Model

Food Safety and Health, EarlyView.
Fenugreek and stevia extracts protect against dexamethasone‐induced testicular damage in male rats by enhancing antioxidant defenses, improving sperm quality, and restoring hormonal balance, highlighting their potential as natural therapeutics for preventing corticosteroid‐induced reproductive toxicity.
Mosab Gad, Medhat Ibrahim A. Omar, Mohammed I. Elkhateeb, Ahmed A. Zaky   +3 more
wiley   +1 more source

HMG-CoA-reductase inhibitors and neuropathy:reports to the Netherlands Pharmacovigilance Centre

, 2006
The number of patients taking HMG-CoA-reductase inhibitors for hypercholesterolaemia is growing rapidly. Treatment with HMG-CoA-reductase inhibitors significantly reduces the risk of cardiovascular morbidity and mortality, but may rarely cause serious ...
de Langen, J J, van Puijenbroek, E P; id_orcid   +1 more
core   +2 more sources