Results 21 to 30 of about 200,536 (178)

Inhibitory effects on the HMG-CoA Reductase in the chemical constituents of the Cassia mimosoides Linn

Romanian Journal of Laboratory Medicine, 2016
Cassia mimosoides Linn has been used from ancient times and used for treating hepatitis for its supposedly medically beneficial properties. In this study, different constituents of the Cassia mimosoides Linn (β-Sitosterol, Oleanolic Acid, Emodin ...
Shen Chuangpeng, Huang Liping, Xiang Hua, Deng Minzhen, Gao Huahong, Zhu Zhangzhi, Liu Min, Luo Guangbo   +7 more
doaj   +1 more source

Effect of cutaneous permeability barrier disruption on HMG-CoA reductase, LDL receptor, and apolipoprotein E mRNA levels in the epidermis of hairless mice.

Journal of Lipid Research, 1992
Disruption of the permeability barrier results in an increase in cholesterol synthesis in the epidermis. Inhibition of cholesterol synthesis impairs the repair and maintenance of barrier function.
S M Jackson, L C Wood, S Lauer, J M Taylor, A D Cooper, P M Elias, K R Feingold   +6 more
doaj   +1 more source

Effect and mechanism of HMG-CoA reductase inhibitor on the improvement of elderly essential hypertension-induced vascular endothelial function impairment based on the JAK/STAT pathway

Diagnostic Pathology, 2023
Objective Our research was designed to figure out the influence and mechanism of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor on the improvement of elderly essential hypertension-induced vascular endothelial function impairment ...
Wen Yuan, Hongjun Fan, Haibing Yang, Liang Tang, Zhiming Liu, Fan Ouyang, Wei Luo, Yong Yan   +7 more
doaj   +1 more source

Differences in mechanisms of modulation between rat liver cholesterol 7α-hydroxylase and HMG-CoA reductase [PDF]

, 1985
The effects of microsomal HMG-CoA reductase kinase, cytosolic phosphoprotein phosphatase and cytosolic, thiol-dependent cholesterol 7α-hydroxylase stimulatory protein on purified cholesterol 7α-hydroxylase and HMG-CoA reductase from rat liver were ...
Bodil Lidström-Olsson, Lidström-Olsson, Bodil   +1 more
core   +1 more source

Down-regulation of cholesterol biosynthesis in sitosterolemia: diminished activities of acetoacetyl-CoA thiolase, 3-hydroxy-3-methylglutaryl-CoA synthase, reductase, squalene synthase, and 7-dehydrocholesterol Δ7-reductase in liver and mononuclear leukocytes

Journal of Lipid Research, 1998
Sitosterolemia is a recessively inherited disorder characterized by abnormally increased plasma and tissue plant sterol concentrations. Patients have markedly reduced whole body cholesterol biosynthesis associated with suppressed hepatic, ileal, and ...
Akira Honda, Gerald Salen, Lien B. Nguyen, G. Stephen Tint, Ashok K. Batta, Sarah Shefer   +5 more
doaj   +1 more source

The impact of HMG CoA reductase on esterases and leptin [PDF]

, 2016
Cilj ovog rada bio je ispitati utjecaj inhibitora HMG –CoA reduktaze na esteraze i leptin. Inhibitori HMG – CoA reduktaze ili statini su lijekovi koji se često koriste u liječenju hiperkolesterolemije. HMG – CoA reduktaza je enzim koji katalizira ključni
Gredelj, Maja
core   +1 more source

Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity

Journal of Lipid Research, 1998
The effects of atorvastatin on the expression of the hepatic HMG-CoA reductase and LDL receptor genes were investigated in rats. Like the other statins, atorvastatin increased the rate of degradation and presumably cycling of the hepatic LDL receptor. In
Gene C. Ness, Christopher M. Chambers, Dayami Lopez   +2 more
doaj   +1 more source

Enhanced seed phytosterol accumulation through expression of a modified HMG-CoA reductase

, 2006
The regulation of phytosterol biosynthesis in seeds is of interest to biotechnologists because of the efficacy of dietary phytosterols in reducing blood cholesterol in humans.
Powers, S. J., Hey, S. J., Hawkins, N. D., Halford, N. G., Beale, M. H., Ward, J. L.   +5 more
core   +1 more source

Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells.

Journal of Lipid Research, 1996
Within the cholesterol biosynthesis cascade, the enzyme 2,3-oxidosqualene cyclase [EC 5.4.99.7] is of special interest due to its dual function: cyclization of 2,3-monoepoxysqualene to lanosterol and 2,3;22,23-diepoxysqualene to oxylanosterol.
M Mark, P Muller, R Maier, B Eisele
doaj   +1 more source

3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors Enhance Cytokine-mediated Induction of Nitric Oxide Synthesis in Vascular Smooth Muscle Cells

Pteridines, 2002
We investigated the effects of by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, cerivastatin and fluvastatin, on the induction of nitric oxide (NO) production in vascular smooth muscle cells ( VSMC) stimulated by interleukin-1β (1L-1) or in ...
Hattori Yoshiyuki, Nakanishi Nobuo, Suzuki Manabu, Yoshida Mika, Kasai Kikuo   +4 more
doaj   +1 more source