Results 11 to 20 of about 36,764 (181)

HMG-CoA reductase is a potential therapeutic target for migraine: a mendelian randomization study. [PDF]

Sci Rep
Statins are thought to have positive effects on migraine but existing data are inconclusive. We aimed to evaluate the causal effect of such drugs on migraines using Mendelian randomization. We used four types of genetic instruments as proxies for HMG-CoA
Qu K, Li MX, Yu P, International Headache Genetics Consortium, Wu BH, Shi M, Dong M.   +6 more
europepmc   +6 more sources

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Investigating the Effects of Statins on Cellular Lipid Metabolism Using a Yeast Expression System [PDF]

, 2009
In humans, defects in lipid metabolism are associated with a number of severe diseases such as atherosclerosis, obesity and type II diabetes. Hypercholesterolemia is a primary risk factor for coronary artery disease, the major cause of premature deaths
Zimnicka, Magdalena, Joanna Kaminska, Burzynska, Beata, Kania Magdalena, Wysocka-Kapcinska, Monika, Beata Burzynska, Witold Danikiewicz, Danikiewicz Witold, Plochocka, Danuta, Leszczynska, Agata, Leszczynska Agata, Zimnicka Magdalena, Danikiewicz, Witold, Wysocka-Kapcinska Monika, Magdalena Kania, Kiliszek Marek, Marek Kiliszek, Kaminska Joanna, Agata Leszczynska, Danuta Plochocka, Magdalena Zimnicka, Kaminska, Joanna, Plochocka Danuta, Szkopinska, Anna, Anna Szkopinska, Kania, Magdalena, Kiliszek, Marek, Szkopinska Anna, Monika Wysocka-Kapcinska, Burzynska Beata   +29 more
core   +1 more source

HMG-CoA Reductase Inhibition Promotes Neurological Recovery, Peri-Lesional Tissue Remodeling, and Contralesional Pyramidal Tract Plasticity after Focal Cerebral Ischemia [PDF]

, 2014
3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are widely used for secondary stroke prevention. Besides their lipid-lowering activity, pleiotropic effects on neuronal survival, angiogenesis, and neurogenesis have been described.
Kilic, Ertugrul, Muhsine Sinem Ethemoglu, Mustafa Caglar Beker, Ulkan eKilic, Beker, Mustafa Caglar, Ozturk, Gurkan, Ahmet Burak Caglayan, Kılıç, Ertuğrul, Kelestemur, Taha, Hermann, Dirk M, Ertugrul Kilic, Hermann, Dirk M., Reitmeir, Raluca, Ethemoglu, Muhsine Sinem, Taha Kelestemur, Dirk M. Hermann, Ãœlkan Kilic, Raluca eReitmeir, Kılıç, Ülkan, Taha eKelestemur, Gurkan eOzturk, Gurkan Ozturk, Caglayan, Ahmet Burak, Kilic, Ülkan, Raluca Reitmeir, Ertugrul eKilic   +25 more
core   +1 more source

HMG-CoA Reductase Inhibitory Activity Potential of Iota-, Kappa-, and Lambda-carrageenan: A Molecular Docking Approach

, 2022
HMG-CoA reductase is an essential enzyme responsible for the biosynthesis of cholesterol. Hyperactivity of HMG-CoA reductase will increase cholesterol production, leading to the elevation of blood cholesterol levels.
Wismayani, Leni, Muh Ikhlas Arsul, Setiawansyah, Arif, Adliani, Nur   +3 more
core   +1 more source

QSAR Regression Models for Predicting HMG-CoA Reductase Inhibition. [PDF]

Pharmaceuticals (Basel)
Background/Objectives: HMG-CoA reductase is an enzyme that regulates the initial stage of cholesterol synthesis, and its inhibitors are widely used in the treatment of cardiovascular diseases.
Ancuceanu R, Popovici PC, Drăgănescu D, Busnatu Ș, Lascu BE, Dinu M.   +5 more
europepmc   +2 more sources

Enhanced seed phytosterol accumulation through expression of a modified HMG-CoA reductase

, 2006
The regulation of phytosterol biosynthesis in seeds is of interest to biotechnologists because of the efficacy of dietary phytosterols in reducing blood cholesterol in humans.
Powers, S. J., Hey, S. J., Hawkins, N. D., Halford, N. G., Beale, M. H., Ward, J. L.   +5 more
core   +1 more source

Chemoembolization combined with pravastatin improves survival in patients with hepatocellular carcinoma [PDF]

, 2008
BACKGROUND/AIMS: Pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, has been shown to inhibit growth and to induce apoptosis in human hepatocellular carcinoma (HCC) cells.
Straub, Gundula, Dogan, Selin, Göke, Burkhard, Dogan, S, Seidel, D, Walli, Autar, Graf, H, Jakobs, T, Hoffmann, Ralf-Thorsten, Reiser, Maximilian F., Straub, G, Juengst, Christoph, Reiser, M, Walli, A, Hoffmann, R T, Walter, A, Seidel, Dietrich, Jüngst, C, Waggershauser, T, Jüngst, D, Göke, B, Walter, Andreas, Graf, Hannah, Helmberger, Thomas, Jakobs, Tobias, Juengst, Dieter, Helmberger, T, Waggershauser, Tobias   +27 more
core   +1 more source

Rapid reverse phase-HPLC assay of HMG-CoA reductase activity. [PDF]

, 2010
Radioisotope-based and mass spectrometry coupled to chromatographic techniques are the conventional methods for monitoring HMG-CoA reductase (HMGR) activity.
ANGELETTI, Mauro, CUCCIOLONI, Massimiliano, MOZZICAFREDDO, MATTEO, ELEUTERI, Anna Maria   +3 more
core   +2 more sources

Liver function testing in patients on HMG-CoA reductase inhibitors

, 2011
PURPOSE: The Food and Drug Administration currently requires the labeling of HMG-CoA reductase inhibitors to recommend liver function tests (LFTs) before the start of therapy and at various intervals during therapy, depending on the specific agent.
Donahue, James G., Platt, Richard, Chan, K. Arnold, Andrade, Susan E., Watson, Douglas J.   +4 more
core   +1 more source