Inhibition of HMG CoA Reductase and Lipid Peroxidation in The Rats Liver by Selected Zingiberaceae [PDF]
Pharmaciana, 2018 Cardiovascular disease is the leading cause of death worldwide. One of the major risk factors for cardiovascular disease is hyperlipidemia. This study aimed to determine the potential of Zingiberaceae (10 species) as inhibitor of HMG-CoA reductase enzyme
Patonah Hasimun +3 more
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HMG-CoA reductase inhibition promotes neurological recovery, perilesional tissue remodeling and contralesional pyramidal tract plasticity after focal cerebral ischemia [PDF]
Frontiers in Cellular Neuroscience, 2014 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are widely used for secondary stroke prevention. Besides their lipid-lowering activity, pleiotropic effects on neuronal survival, angiogenesis and neurogenesis have been described.
Ertugrul eKilic +8 more
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Drug Design, Development and Therapy, 2015 Gunasekaran Baskaran,1 Shamala Salvamani,1 Siti Aqlima Ahmad,1 Noor Azmi Shaharuddin,1 Parveen Devi Pattiram,2 Mohd Yunus Shukor1 1Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, 2Department of Food Technology ...
Baskaran G +5 more
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Influence of simvA glyzin on expression and inhibition of hmg-coa reductase in rats liver
Атеросклероз, 2015 Activity, level of protein and mRNA HMG-CoA reductase were investigated in rats liver treated with simvastatin (SV), its complex compound with glycyrrhizic acid – simvaglyzin (SVG) and glycyrrhizic acid alone.
Yu. I. Ragino +7 more
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Investigating the Effects of Statins on Cellular Lipid Metabolism Using a Yeast Expression System [PDF]
, 2009 In humans, defects in lipid metabolism are associated with a number of severe diseases such as atherosclerosis, obesity and type II diabetes. Hypercholesterolemia is a primary risk factor for coronary artery disease, the major cause of premature deaths
Zimnicka, Magdalena +9 more
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HMG-CoA Reductase Inhibitory Activity Potential of Iota-, Kappa-, and Lambda-carrageenan: A Molecular Docking Approach [PDF]
, 2022 HMG-CoA reductase is an essential enzyme responsible for the biosynthesis of cholesterol. Hyperactivity of HMG-CoA reductase will increase cholesterol production, leading to the elevation of blood cholesterol levels.
Wismayani, Leni +3 more
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Journal of Lipid Research, 1989 The localization of reactive cysteines and characterization of the HMG-CoA binding domain of rat liver HMG-CoA reductase were studied using iodoacetamide (IAAD) and short-chain acyl-CoA thioesters.
J Roitelman, I Shechter
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Improved methods for the assay and activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Journal of Lipid Research, 1979 A simple and rapid mixed-phase method for the quantitative assay of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase and a procedure for the efficient reactivation of Mg-ATP-inactivated microsomal HMG-CoA reductase by potato acid phosphatase are described.
B W Philipp, D J Shapiro
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Isolation and purification of 3-hydroxy-3-methylglutaryl-coenzyme A by ion-exchange chromatography
Journal of Lipid Research, 1981 For precise determination of the catalytic activity of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (EC 1.1.1.34), the HMG-CoA employed as substrate must be free of HMG, CoA, and other inhibitors of HMG-CoA reductase activity.
I P Williamson, V W Rodwell
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Journal of Lipid Research, 1992 The ability of mitogenic stimulation of human T lymphocytes to alter the expression of genes involved in sterol metabolism was examined. Messenger RNA levels for 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, HMG-CoA synthase, and low density
JA Cuthbert, PE Lipsky
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