Results 51 to 60 of about 200,536 (178)
ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential
iNew Medicine, EarlyView.ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang +5 more
wiley +1 more source
Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal +2 more
wiley +1 more source
Hepatic HMG-CoA Reductase Expression and Resistance to Dietary Cholesterol
, 2004 The premise that the intrinsic level of expression of hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase determines the relative sensitivity to the serum cholesterol raising action of dietary cholesterol was examined in 9 strains of rat ...
Karen R. Gertz, Gene C. Ness
core +1 more source
HMG-CoA-reductase inhibitors and neuropathy:reports to the Netherlands Pharmacovigilance Centre
, 2006 The number of patients taking HMG-CoA-reductase inhibitors for hypercholesterolaemia is growing rapidly. Treatment with HMG-CoA-reductase inhibitors significantly reduces the risk of cardiovascular morbidity and mortality, but may rarely cause serious ...
de Langen, J J +1 more
core +2 more sources
Rapid reverse phase-HPLC assay of HMG-CoA reductase activity [PDF]
, 2010 Radioisotope-based and mass spectrometry coupled to chromatographic techniques are the conventional methods for monitoring HMG-CoA reductase (HMGR) activity.
Mozzicafreddo M. +3 more
core +2 more sources
Journal of Lipid Research, 1993 The mechanism of down-regulation of hepatic HMG-CoA reductase and cholesterol 7 alpha-hydroxylase by cholic acid (CA) and chenodeoxycholic acid (CDCA) was investigated in rats with a lymph fistula.
I Björkhem +4 more
doaj +1 more source
JSFA reports, EarlyView.Abstract The dietary and lifestyle practices have predominantly compromised human health, which are influenced by modernization and industrialization. Hypercholesterolemia, caused by the consumption of fatty and fried foods and a sedentary lifestyle, is a major modifiable risk factor for cardiovascular disease and commonly coexists with obesity ...
Muhammad Usman Khalid +8 more
wiley +1 more source
Effects of myosin heavy chain (MHC) plasticity induced by HMGCoA-reductase inhibition on skeletal muscle functions. [PDF]
, 2011 The rate-limiting step of cholesterol biosynthetic pathway is catalyzed by 3-hydroxy-3-methylglutaryl coenzyme reductase (HGMR), whose inhibitors, the statins, widely used in clinical practice to treat hypercholesterolemia, often cause myopathy, and ...
Moreno, Sandra +34 more
core +2 more sources
Mass Spectrometry Reviews, EarlyView.ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley +1 more source
, 2016 HMG-CoA reductase (HMGR) is an enzyme critical for cellular cholesterol synthesis in mammals and isoprenoid synthesis in certain eubacteria, catalyzing the NAD(P)H-dependent reduction of HMG-CoA to mevalonate.
Amy E. Theivagt (2517007) +4 more
core +2 more sources