Results 71 to 80 of about 36,764 (181)
British Journal of Pharmacology, Volume 183, Issue 11, Page 2675-2694, June 2026.Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng +10 more
wiley +1 more source
Diabetic Medicine, Volume 43, Issue 6, June 2026.Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye +18 more
wiley +1 more source
Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1687-1691, June 2026.ABSTRACT Background Evidence supporting the use of statins for primary prevention of cardiovascular disease (CVD) in individuals aged ≥ 80 years remains limited. This study aimed to evaluate the long‐term clinical benefits and safety of statins for primary prevention in patients aged 80 years and older.
Ophir Lavon, Wafaa Hamodi, Sameer Kassem
wiley +1 more source
MTD-comsia modelling of HMG-CoA reductase inhibitors
, 2011 The 3D quantitative structure-activity relationship for a series of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors based on the pyrrolylethyl-tetrahydropyranone scaffold was examined using the Minimal Topological Difference (MTD ...
Corina Duda-Seiman +6 more
core +1 more source
Journal of Neurochemistry, Volume 170, Issue 6, June 2026.Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Myuri Ruthirakuhan +2 more
wiley +1 more source
, 2000 The activity of the HMG-CoA reductases of higher eukaryotes is regulated by reversible phosphorylation of a putative active site serine. Mutagenic and kinetic evidence suggested that interaction between phosphoserine and the catalytic histidine, negates ...
Kim, Dong-Yul
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MTD–CoMSIA modelling of HMG-CoA reductase inhibitors [PDF]
, 2010 The 3D quantitative structure–activity relationship for a series of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors based on the pyrrolylethyl-tetrahydropyranone scaffold was examined using the Minimal Topological Difference (MTD) method and ...
VALENTIN CAREJA +6 more
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HMG-CoA reductase 활성과 장내 미생물 생육에 대한 플라보노이드의 영향
, 2003 Thesis (master`s)--서울대학교 대학원 :농생명공학부,2003.The effects of flavonoids an inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which is rate limiting enzyme in cholesterol biosynthesis, and growth-inhibition of intestinal microflora ...
전구주
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Pityriasis Lichenoides Chronica Associated with Use of HMG-CoA Reductase Inhibitors
, 2012 Herein, we present three cases of Pityriasis lichenoides chronica (PLC) in patients who developed the rash after use of 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase inhibitors.
• RJB Massay, AA Maynard
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Influence of simvA glyzin on expression and inhibition of hmg-coa reductase in rats liver
, 2015 Activity, level of protein and mRNA HMG-CoA reductase were investigated in rats liver treated with simvastatin (SV), its complex compound with glycyrrhizic acid – simvaglyzin (SVG) and glycyrrhizic acid alone.
Yu. P. Nikitin +7 more
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