Results 241 to 250 of about 137,694 (300)

Circadian reprogramming by timed sodium intake reveals transcriptional pathways of daily salt handling in the colon. [PDF]

Sci Adv
Torimitsu T, Kinouchi K, Changizi Ashtiani K, Abdelkarim S, Sato T, Kozuma T, Yao N, Iwahara A, Kato K, Tonomura S, Nakamura T, Yokota K, Kurihara I, Baldi P, Itoh H, Hayashi K.   +15 more
europepmc   +1 more source

Exploring a Subpopulation of MASLD Associated With New Onset of CKD Using Supervised Clustering Techniques

Hepatology Research, EarlyView.
The supervised clustering of metabolic dysfunction‐associated steatotic liver disease (MASLD) using a SHapley Additive exPlanations (SHAP)‐converted matrix reveals distinct subpopulations that improved risk stratification for new onset of chronic kidney disease (CKD).
Itaru Hosaka, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Keitaro Nishizawa, Rie Matsumori, Hiroki Aida, Wataru Kawaharata, Kei Nakata, Koki Abe, Toru Suzuki, Hidemichi Kouzu, Naoya Yama, Nagisa Hanawa, Masato Furuhashi   +14 more
wiley   +1 more source

Continuous glucose monitoring reveals bimodal glycemic patterns during and outside Capivasertib administration

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Capivasertib, an AKT inhibitor, interferes with insulin signaling and can induce hyperglycemia. In this case, we monitored blood glucose fluctuations using continuous glucose monitoring (CGM) during capivasertib administration. During the administration period, a post‐dose increase in blood glucose was observed, peaking approximately 4 h after
Yuya Suzuki, Takeshi Yamaguchi, Takayasu Uchida, Kimio Matsumura, Nozomi Harai, Kaoru Nagasawa, Yuko Tanabe, Koichi Suyama, Takashi Kadowaki, Yasumichi Mori   +9 more
wiley   +1 more source

Proliferative Kidney Disease and Viral Pathogens in Wild Brown Trout (Salmo trutta) Populations in the Czech Republic

Journal of Fish Diseases, EarlyView.
ABSTRACT Populations of wild brown trout (Salmo trutta) have been in long‐term decline across Central Europe, including the Czech Republic, with multiple factors, such as habitat alteration, climate change, predation and emerging diseases, implicated.
Miroslava Palíková, Ivana Mikulíková, Tomáš Doležal, Ivana Papežíková, Kateřina Matějíčková, Jitka Motlová, Hana Novotná, Ivona Toulová, Jan Grmela, Anna Šindelářová, Ľubomír Pojezdal   +10 more
wiley   +1 more source

Newly identified intervertebral fat pad degenerates after intervertebral disc injury in a rat model of degeneration

Journal of Anatomy, EarlyView.
This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne, Irina Heggli, Agnieszka A. Karol, Alon Lai, Svenja Illien‐Jünger, Andrew C. Hecht, Nilsson Holguin, James C. Iatridis   +7 more
wiley   +1 more source

AGP and EXO‐LIKE genes promote brassinosteroid‐dependent anisotropic growth

New Phytologist, EarlyView.
Summary The brassinosteroid pathway promotes anisotropic cell expansion; however, the effectors in this process remain unclear. Candidates include ARABINOGALACTAN PROTEIN (AGP) genes, which are prominent brassinosteroid‐responsive transcriptional targets, and EXORDIUM (EXO)‐LIKE (EXL) genes.
Daria Novikova, Surbhi Rana, Kunkun Li, H. Nicholay Diaz‐Ardila, Nicola Trozzi, Luis Alonso Baez, Thorsten Hamann, Mateusz Majda, Christian S. Hardtke   +8 more
wiley   +1 more source

The C2H2‐GGAT Regulatory Module Fine‐Tunes Glutamate Homeostasis to Improve Fruit Flavour and Enhance Disease Resistance in Peach

Plant Biotechnology Journal, EarlyView.
ABSTRACT Free amino acids (FAAs) play a fundamental role in determining fruit quality and stress adaptation, yet their genetic regulation remains poorly understood. Through an integrated approach combining metabolomic and sensory analyses of 120 peach (Prunus persica) hybrids, we identified glutamate as a key metabolite linking FAA content to umami ...
Yike Su, Xiaojuan Yang, Chanyuan Wu, Xianyao Jin, Yuanyuan Zhang, Yuyan Zhang, Kunsong Chen, Mingliang Yu, Bo Zhang   +8 more
wiley   +1 more source

An Elite Haplotype of Nitrogen‐Use‐Efficiency Gene LHT5 Enhances Salt Tolerance in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Amino acids serve as fundamental building blocks and signalling molecules in plants, orchestrating stress adaptation mechanisms against diverse biotic and abiotic environmental challenges. However, the mechanism by which plants alter their nutrient metabolism processes to coordinate nitrogen use efficiency (NUE) and salt tolerance remains ...
Saisai Wang, Xingzhou Jiang, Gaoming Chen, Wei Wu, Chen Xu, Mingyu Du, Shuji Xiang, Xinran Cheng, Yunlu Tian, Junjie Tan, Chunming Wang, Jianmin Wan   +11 more
wiley   +1 more source

Chromosome‐Level Genome Assembly of the Allotetraploid Gynostemma pentaphyllum Provides Novel Insights Into the Biosynthesis of Ginsenoside and Gypenoside LVI

Plant Biotechnology Journal, EarlyView.
ABSTRACT Gynostemma pentaphyllum, a herb used in tea and traditional Chinese medicine, shows geographic variation in its production of valuable dammarane‐type ginsenosides and gypenoside LVI between populations from Suining (SN) and Nanning (NN). To elucidate the mechanisms underlying this differential metabolite accumulation, a chromosome‐level genome
Peina Zhou, Si‐Jie Liu, Lijin Huang, Yingping Wang, Xinyu Jiang, Wang Dong, Jianfeng Gong, Long Wang, Yuyin Zhao, Huiying Wang, Ping Li, Jia‐Yu Xue, Xu Lu   +12 more
wiley   +1 more source

Proteomics analysis of nitrogen stress on the influence of carbon and nitrogen metabolism of flue-cured tobacco. [PDF]

BMC Genomics
Zhang X, Pan S, Chen D, Pan Y, Xu T, Zhang J, Huang Y.   +6 more
europepmc   +1 more source