Results 91 to 100 of about 32,692 (251)

Impact of Co‐Morbid Immunocompromise in HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

The Laryngoscope, EarlyView.
Among patients with surgically resected Human Papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC), immunocompromised patients had significantly worse overall survival compared to the non‐compromised group; however, these exploratory findings should be interpreted cautiously.
Maxwell L. Weng, Tereza Vitkovska, Song Hon Hwang, Lauran K. Evans, Hong‐Ho Yang, Christopher Dann, Dipti Sajed, Maie A. St. John   +7 more
wiley   +1 more source

Effects of NDURE on Timely Adjuvant Radiotherapy in HNSCC: Subgroup Analysis of an RCT

The Laryngoscope, EarlyView.
In this subgroup analysis of a randomized clinical trial of 145 patients with locally advanced head and neck squamous cell carcinoma, the enhanced navigation‐based intervention NDURE improved initiation of timely postoperative radiation therapy (PORT) relative to usual care across nearly all demographic and clinical subgroups, including patients with ...
Jonathan M. Hughes, Emily Kistner‐Griffin, Reid DeMass, Bhisham S. Chera, Katherine R. Sterba, Elizabeth G. Hill, Jessica McCay, Jason G. Newman, W. Greer Albergotti, Alex E. Kejner, Judith M. Skoner, Jennifer L. Harper, John Kaczmar, Byung Joo Lee, Savannah A. Zimmerman, Graham W. Warren, Anthony J. Alberg, Elizabeth A. Calhoun, Brian Nussenbaum, Chanita Hughes‐Halbert, Evan M. Graboyes   +20 more
wiley   +1 more source

Bilateral Ophthalmoplegia After Neoadjuvant Pembrolizumab for Oral Cavity Squamous Cell Carcinoma

The Laryngoscope, EarlyView.
The role of immune checkpoint inhibition (ICI) therapy in the treatment of head and neck squamous cell carcinoma (HNSCC) is expanding with increased utilization of neoadjuvant and adjuvant pembrolizumab in the setting of locally advanced disease. This report describes the presentation and management of the first known case of pembrolizumab‐induced ...
Leonard E. Estephan, Peter Jacoby, David M. Cognetti, Steven A. Manobianco   +3 more
wiley   +1 more source

Accelerated Biological Aging Increases the Risk of Head and Neck Cancer: Insights From Genetic Instruments of Epigenetic Clocks

Molecular Carcinogenesis, EarlyView.
ABSTRACT Epigenetic clocks are robust biomarkers of biological aging and have been associated with cancer susceptibility. However, the relationship between genetically predicted epigenetic age acceleration and head and neck cancer risk remains unclear. Using a large case‐control study of 2189 head and neck squamous cell carcinoma (HNSCC) cases and 2189
Jiaqi Wang, Jie Deng, Yifan Xu, Chia‐Wen Tsai, Wen‐Shin Chang, Yang Deng, Maosheng Huang, Da‐Tian Bau, Guojun Li, Jian Gu   +9 more
wiley   +1 more source

Margin Status and Local Recurrence in Early‐Stage Oral‐Cavity Squamous Cell Carcinoma: Analysis of Reresection Outcomes

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To assess the impact of surgical margin status and re‐resection on local recurrence (LR) in early‐stage oral cavity squamous cell carcinoma (OCSCC). Study Design Retrospective analysis of 352 patients with cT1‐2N0 OCSCC. Setting Tertiary care center from 2005 to 2024.
Hannah J. Brown, Naomi C. Wang, Rahul Alapati, Uma Ramesh, Ameen M. Amanian, Andrés M. Bur   +5 more
wiley   +1 more source

Nurse Navigation on Time to Postoperative Radiation Therapy after Transoral Robotic Surgery for Oropharyngeal Carcinoma

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Postoperative radiation therapy (PORT) initiation within 6 weeks of surgery is associated with improved oncologic outcomes in head and neck cancer, but delays remain common. Oncology nurse navigators (ONN) may improve care coordination.
Vera Bzhilyanskaya, Jane Y. Tong, Theresa Vetter‐Habighorst, Kelly Moyer, Jeffrey Wolf, Rodney Taylor, Jason K. Molitoris, Matthew J. Ferris, Ranee Mehra, Kyle M. Hatten   +9 more
wiley   +1 more source

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

COX5A promotes cell progression and cisplatin‐resistance by alleviating mitochondrial dysfunction in head and neck squamous cell carcinoma

Precision Medical Sciences, EarlyView.
COX5A promotes cell progression and cisplatin‐resistance and alleviates mitochondrial dysfunction. ISG15 shows a reversing role with COX5A. Targeting the COX5A‐mediated mitochondrial metabolic pathway may offer a novel therapeutic approach to enhance cisplatin sensitivity in HNSCC.
Nannan Guo, Zhangyu Yao, Bo Gui, Qingya Sun, Yihan Tang, Tingting Hu, Yanbin Zhao, Fangzhou Liu   +7 more
wiley   +1 more source

Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma

Precision Radiation Oncology, EarlyView.
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhaoyuan Zhang, Junyan Li, Minhua Fan, Huafu Ouyang, Qiubo Chu, Huijie Yan, Yannan Zheng, Linxuan Huang, Gui Bao, Zhenting Ma, Shaobo Huang, Lin Li, Xiao Xu, Zhigang Liu   +13 more
wiley   +1 more source

Tumor suppressor ACER1 correlates with prognosis and Immune Infiltration in head and neck squamous cell carcinoma

Scientific Reports
Head and neck squamous cell carcinoma (HNSCC) is notorious for poor prognoses, and effective biomarkers are urgently needed for early diagnosis of HNSCC patients.
Zhixin Liu, Xiaoqi Yang, Shuai Chen, Wenming Jia, Ye Qian, Minfa Zhang, Tianhe Fang, Heng Liu, Hui Yang   +8 more
doaj   +1 more source