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Preclinical models of HPV+ and HPV− HNSCC in mice: An immune clearance of HPV+ HNSCC
Head & Neck, 2009AbstractBackground.To investigate whether human papilloma virus (HPV)‐specific immune mechanisms can result in tumor clearance, we have created HPV+ and HPV− tonsil cells that form squamous cancers in immune‐competent mice. Here, we determine that an immune‐specific response can clear HPV+ tumor cells and the cellular requirements to mediate this tumor
Robin, Williams +5 more
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Vaccination Expectations in HNSCC
2016HPV-associated head and neck squamous cell carcinoma (HNSCC), more specifically the incidence of oropharyngeal cancer, is dramatically increasing in industrialized countries. According to what has been learned from anogenital vaccination programs, there are reasons to believe that current human papillomavirus (HPV) vaccinations may be potentially ...
Rautava Jaana, Syrjänen Stina
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Frontiers in Genetics, 2022 Background: Radioresistance in head and neck squamous cell carcinoma (HNSCC) patients means response failure to current treatment. In order to screen radioresistant biomarkers and mechanisms associated with HNSCC, differentially expressed genes (DEGs ...
Qinglai Tang +2 more
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Docetaxel induction combination for HNSCC
The Lancet Oncology, 2007Addition of docetaxel to cisplatin and fl uorouracil in locally advanced unresectable head and neck squamous cell cancer (HNSCC) imp roves progressionfree survival (N Engl J Med 2007; 357: 1695–704) and overall survival (N Engl J Med 2007; 357: 1705–15).
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Pattern of Failure Among HNSCC
Bengal Journal of Cancer, 2021Aim: This retrospective study was conducted to evaluate the pattern of recurrence in head and neck squamous cell carcinoma (HNSCC) patients who received a definitive chemo-radiotherapy. Materials and Methods: In this retrospective study, the data of 308 head and neck patients from ...
Afsana Shah +3 more
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2023
Abstract Background The study of molecular markers for diagnosis and prognosis is of great clinical significance for HNSCC patients. In this study, we proposed that FSCN1 has a potential indication for prognosis and is essential for the migration of HNSCC.
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Abstract Background The study of molecular markers for diagnosis and prognosis is of great clinical significance for HNSCC patients. In this study, we proposed that FSCN1 has a potential indication for prognosis and is essential for the migration of HNSCC.
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Otolaryngology–Head and Neck Surgery, 2008
ProblemDown regulation of E‐cadherin is the hallmark of epithelial mesenchymal transition (EMT). The loss of E‐cadherin confers a more invasive phenotype and is one of the steps leading to metastasis. Our recent investigations indicate that inflammatory mediators are potent regulators of EMT in HNSCC.MethodsImmunohistochemical analysis of HNSCC tumor ...
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ProblemDown regulation of E‐cadherin is the hallmark of epithelial mesenchymal transition (EMT). The loss of E‐cadherin confers a more invasive phenotype and is one of the steps leading to metastasis. Our recent investigations indicate that inflammatory mediators are potent regulators of EMT in HNSCC.MethodsImmunohistochemical analysis of HNSCC tumor ...
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Preclinical models in HNSCC: A comprehensive review
Oral Oncology, 2017Head and neck cancer remains a significant public health concern. About 60% of patients die within 5years due to local recurrence. Head and neck squamous cell carcinoma (HNSCC) cell lines are important preclinical models in the search for new therapies against this disease.
Méry, Benoîte +10 more
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Human Papillomavirus in HNSCC: A European Epidemiologic Perspective
Hematology/Oncology Clinics of North America, 2008The aim of this study was to assess incidence and survival of human papillomavirus-related and unrelated head and neck squamous cell carcinoma sites from 15 European population-based cancer registries. This analysis was performed on 29,265 adult (aged approximately 15 years) cancer patients diagnosed in the period from 1988 to 2002.
L. Licitra +4 more
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Impact of AIM2 on HNSCC Development
Abstract Head and neck squamous cell carcinoma (HNSCC) constitutes 90% of head and neck cancers. HNSCC development is linked to chronic inflammation, while established HNSCC tumors are often immune suppressive. However, both occur through mechanisms that are not fully understood.Dakota M. Reinartz +4 more
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