Results 151 to 160 of about 25,300,433 (384)

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice [PDF]

, 2014
Hemolysis, oxidative stress, inflammation, vaso-occlusion and organ infarction are hallmarks of sickle cell disease (SCD). We have previously shown that increases in heme oxygenase-1 (HO-1) activity detoxify heme and inhibit vaso-occlusion in transgenic ...
Carol M. Bruzzone, Chunsheng Chen, Clifford J. Steer, Fatima B. Khan, Graham Brown, Gregory M. Vercellotti, Heather Bechtel, John D. Belcher, Julia Nguyen, Karl A. Nath, Robert P. Hebbel   +10 more
core   +2 more sources

Punicalagin attenuates TNF-α-induced oxidative damage and promotes osteogenic differentiation of bone mesenchymal stem cells by activating the Nrf2/HO-1 pathway

, 2023
Lei Huang, Shunyi Lu, Mengxuan Bian, Jiayi Wang, Jieqin Yu, Jun Ge, Jian Zhang, Qintong Xu   +7 more
openalex   +1 more source

Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway

OncoTarget, 2017
Osteoporosis is a disorder of bone and its development is closely associated with oxidative stress and reactive oxygen species (ROS). Chlorogenic acid (CGA) has potential antioxidant effects and its pharmacological action in osteoblasts is not clearly ...
Dandan Han, Wei Chen, Xiaolong Gu, Ruixue Shan, Jiaqi Zou, Gang Liu, Muhammad Shahid, Jian Gao, B. Han   +8 more
semanticscholar   +1 more source

Role of HO‐1 in neuroblastoma resistance to Bortezomib

The FASEB Journal, 2013
Neuroblastoma (NB) is the most common solid tumor in childhood and is characterized by a poor prognosis due to the gain of a chemoresistant phenotype. Among the most recent anticancer therapies Bortezomib (BTZ) has shown impressive clinical activity to overcome cancer cell resistance to conventional therapy.
FURFARO, ANNA LISA, PIRAS, SABRINA, PASSALACQUA, MARIO, DOMENICOTTI, CINZIA MARIA, PRONZATO, MARIA ADELAIDE, MARINARI, UMBERTO, MORETTA, LORENZO, TRAVERSO, NICOLA, NITTI, MARIAPAOLA   +8 more
openaire   +2 more sources

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury [PDF]

, 2013
The activation of heme oxygenase-1 (HO-1) appears to be an endogenous defensive mechanism used by cells to reduce inflammation and tissue damage in a number of injury models. HO-1, a stress-responsive enzyme that catabolizes heme into carbon monoxide (CO)
Câmara, Niels Olsen Saraiva, Origassa, Clarice Silvia Taemi   +1 more
core   +1 more source

Research on a flow-mode magneto-rheological impact damper with stroke-activated capability

Vietnam Journal of Mechanics
It is widely recognized that impact is an intricate problem that has challenged scientific scholars for many years. Impacts, such as those occurring in high-speed aircraft landings, vehicle accidents, or machine tool operations, pose substantial hazards
Huu-Quan Nguyen, Quoc-Duy Bui, Duc-Nam Nguyen, Quoc Hung Nguyen, Long-Vuong Hoang   +4 more
doaj   +1 more source

Differential expression of heme oxygenase-1 and vascular endothelial growth factor in cadaveric and living donor kidneys after ischemia-reperfusion [PDF]

, 2003
The extent of graft damage after ischemia-reperfusion reflects the balance between deleterious events and protective factors. Heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) may contribute to cytoprotection by ...
Baan, C.C. (Carla), Engel, S. (Sandra) van den, IJzermans, J.N.M. (Jan), Lemos, F.B.C. (Francine), Mol, W.M. (Wendy), Peeters, A.M.A. (Annemiek), Weimar, W. (Willem), Zondervan, P.E. (Pieter)   +7 more
core   +3 more sources

HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation

Antioxidants, 2017
The upregulation of heme oxygenase-1 (HO-1) is one of the most important mechanisms of cell adaptation to stress. Indeed, the redox sensitive transcription factor Nrf2 is the pivotal regulator of HO-1 induction.
M. Nitti, S. Piras, U. Marinari, L. Moretta, M. Pronzato, A. Furfaro   +5 more
semanticscholar   +1 more source