Results 161 to 170 of about 25,300,433 (384)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events.
Alexandros Rahn +4 more
wiley +1 more source
Protective role of HO-1 in oxidative tissue injuries
Folia Pharmacologica Japonica, 2007 昨今の生命科学の進歩は薬理学の研究をより病態に応じた新薬の開発へと向かわせている．しかし，肝不全，腎不全，多臓器不全など，急性臓器不全は高い死亡率を示すにもかかわらず，その治療において決め手となる薬物は未だ開発されていない．これら急性臓器不全の組織障害の病態生理は完全に明らかでないが，好中球の活性化や虚血・再潅流にともなう酸化ストレスによる細胞傷害が大きな役割を果たしている．酸化ストレスはヘムタンパク質からヘムを遊離させる．遊離ヘムは脂溶性の鉄であることから，活性酸素生成を促進して細胞傷害を悪化させる．この侵襲に対抗するために，ヘム分解の律速酵素：Heme Oxygenase-1（HO-1）が細胞内に誘導される．HO-1によるヘム分解反応産物である一酸化炭素，胆汁色素には，抗炎症・抗酸化作用がある ...
Toru, Takahashi +7 more
openaire +3 more sources
Developmental Disorders in Children Recently Diagnosed With Cancer
Pediatric Blood &Cancer, EarlyView.ABSTRACT Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016–2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer‐free controls.
Jamie Shoag +5 more
wiley +1 more source
Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection [PDF]
, 2013 Heme oxygenases (HO) catalyze the rate-limiting step of heme degradation. The cytoprotective action of the inducible HO-1 isoform, encoded by the Hmox1 gene, is required for host protection against systemic infections. Here we report that upregulation of
Algood +67 more
core +2 more sources
Future Science OABackground Pompe disease (PD) is a rare autosomal recessive disorder caused by pathogenic variants in the GAA gene, resulting in deficient lysosomal acid α-glucosidase activity.
Thanh Huong Thi Nguyen +8 more
doaj +1 more source
International Journal of Nanomedicine, 2022 Li P, Bukhari SNA, Khan T, et al. Int J Nanomedicine. 2020;15:9115–9124. The Editor and Publisher of International Journal of Nanomedicine wish to retract the published article.
Li P +8 more
doaj
Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia–reperfusion injury
Cell Death and Disease, 2017 Cytoprotective gene heme oxygenase 1 (HO-1) could be induced by nuclear factor E2-related factor 2 (Nrf2) nuclear translocation. The purpose of this study was to determine the role of Brahma-related gene 1 (Brg1), a catalytic subunit of SWI2/SNF2-like ...
Mian Ge +8 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker +7 more
wiley +1 more source
Protective role of H2S on acute renal damages in urinary-derived sepsis
Biotechnology & Biotechnological Equipment, 2019 The aim of this study was to investigate the protective roles of H2S on acute renal damage in urinary-derived sepsis. Totally 40 male rabbits were randomly divided into the Control, Sham, Sepsis, NaHS and the dl-propargylglycine (PAG) groups. White blood
Wujun Xu +9 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu +20 more
wiley +1 more source